Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)1728-08692949-1444Eco-Vector1673410.33396/1728-0869-2018-1-60-64Research Article25(OH)D LEVELS IN THE POPULATION OF ARKHANGELSK CITY IN DIFFERENT AGE GROUPSMalyavskayaS I-KostrovaG Nkostrovagn@yandex.ruLebedevA V-GolyshevaE V-KaramyanV G-Northern State Medical UniversityArkhangelsk Children's Hospital named after P. G. VyzhletsovArkhangelsk Clinical Maternity Hospital named after K. N. Samoilov15012018251606423102019Copyright © 2018, Human Ecology2018Vitamin D deficit is a worldwide recognized health problem due to its role in pathogenesis and progression of different diseases. We take special interest in the study of vitamin D supply of different age group population living in the Arctic and subarctic regions where the risk of vitamin D deficit due to the low insolation level is becoming higher because of extreme climatic and geographic factors. Objective: to estimate vitamin D supply among the population of Arkhangelsk city in different age groups. Methods: 25-OH vitamin D blood serum concentration was estimated in a cross-sectional (instant) uncontrolled study carried out among the citizens of both sexes in Arkhangelsk city during spring-autumn period between 2013 and 2014, winter season 2016. Moderate deficit (deficiency) was estimated at the level of 25 (OH) D within the range of 20-30 ng/ml, deficit and severe deficit within the range of 10-19 ng/ ml and less than 10 ng/ml respectively. Results: newborns (n = 55), their mothers (n = 55), children under the age of 3 (n = 155), schoolchildren at the age of 6 and 7 (n = 80), adolescents between the age of 13 and 15 (n = 367), university students between the age of 18 and 22 (n = 260), adults between the age of 24 and 60 (n = 85) were included in the study. Vitamin D deficiency was found in 26, 27, 25, 20, 19, 32 and 41 % people respectively. Deficit was found in 36, 33, 23, 49, 66, 40, and 29 people respectively. Severe deficit was found in 31, 5, 8, 22, 14, 8, and 4 % people studied respectively. Conclusion: high frequency of vitamin D deficit of various degree was revealed in all age group populations living in Arkhangelsk city. Study results indicate the necessity of developing and implementing target regional and all-Russian prevention programmes as well as early diagnosis and correction of vitamin D deficit and deficit-related disorders in the Russian Federation.vitamin Dvitamin D deficiency and vitamin D deficitchildren of early ageschoolchildrenadolescentsadultsвитамин Dнедостаточность и дефицит витамина Dноворожденныематеридети раннего возрасташкольникиподросткивзрослые[Громова О. А., Торшин И. Ю. Витамин D - смена парадигмы. М.: Торус Пресс, 2015. 464 с.][Гудков А. Б., Лукманова Н. Б., Раменская Е. Б. Человек в приполярном регионе Европейского Севера: эколого-физиологические аспекты. Архангельск: ИПЦ САФУ, 2013. 184 с.][Захарова И. Н., Мальцев С. В., Боровик Т. Э., Яцык Г. В., Малявская С. И., Вахлова И. В., Шуматова Т. А., Романцова Е. Б., Романюк Ф. П., Климов Л. Я., Пирожкова Н. И., Колесникова С. М., Курьянинова В. А., Васильева С. В., Мозжухина М. В., Евсеева Е. А. Результаты многоцентрового исследования «Родничок» по изучению недостаточности витамина D у детей раннего возраста в России // Педиатрия. Журнал им. Г. Н. Сперанского. 2015. Т. 94, № 1. С. 62-67.][Поморская энциклопедия: в 5 т. Т. 2: Природа Архангельского Севера. Архангельск, 2007. 603 с.][Профилактика и лечение рахита у детей раннего возраста: метод. реком. МЗ СССР. М., 1990. 31 с.][Торшин И. Ю., Лиманова О. А., Сардарян И. С., Громова О. А., Малявская С. И., Гришина Т. Р., Галустян А. Н., Волков А. Ю., Калачева А. Г., Громов А. Н., Рудаков К. В. Обеспеченность витамином D детей и подростков 7-14 лет и взаимосвязь дефицита витамина D с нарушениями здоровья детей: анализ крупномасштабной выборки пациентов посредством интеллектуального анализа данных // Педиатрия. Журнал им. Г. Н. Сперанского. 2015. Т. 94, № 2. С. 175-184.][Хаснулин В. И., Хаснулин П. В. Современные представления о механизмах формирования северного стресса у человека в высоких широтах // Экология человека. 2012. № 1. С. 3-11][Чащин В. П., Ковшов А. А., Гудков А. Б., Моргунов Б. А. Социально-экономические и поведенческие факторы риска нарушений здоровья среди коренного населения Крайнего Севера // Экология человека. 2016. № 6. С. 3-8.][Abbasian M., Chaman R., Amiri M., Ajami M.E., Jafari-Koshki T., Rohani H., Taghavi-Shahri S. M., Sadeghi E., Raei M. Vitamin D Deficiency in Pregnant Women and Their Neonates // Glob. J. Health Sci. 2016. Vol. 8, N 9. P. 54008. doi: 10.5539/gjhs.v8n9p83][Elamin M. B., Abu Elnour N. O., Elamin K. B., Fatourechi M. M., Alkatib A. A., Almandoz J. P., Liu H., Lane M. A., Mullan R. J., Hazem A., Erwin P. J., Hensrud D. D., Murad M. H., Montori V. M. Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis // J. Clin. Endocrinol. Metab. 2011. Vol. 96, N 7. P. 1931-1942.][Jääskeläinen T., Itkonen S. T., Lundqvist A., Erkkola M., Koskela T., Lakkala K., Dowling K. G., Hull G. L.,Kröger H., Karppinen J., Kyllönen E., Härkänen T., Cashman K. D., Männistö S., Lamberg-Allardt C. The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data // Am. J. Clin. Nutr. 2017. Vol. 105, N 6. P. 1512-1520. doi: 10.3945/ajcn.][Haussler M. R., Haussler C. A., Bartik L., Whitfield G. K., Hsieh J. C., Slater S., Jurutka P. W. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention // Nutr. Rev. 2008. Vol. 66, N 10, suppl. 2. P. S98 -112. doi: 10.1111/j.1753-4887.2008.00093.x. Review.][Holick M. F., Binkley N. C., Bischoff-Ferrari H. A., Gordon C. M., Hanley D. A., Heaney R. P., Murad M. H., Weaver C. M. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline // J. Clin. Endocrinol. Metab. 2011. Vol. 96. P. 1911-1930.][Holick M. F., Chen T. C. Vitamin D deficiency: a worldwide problem with health consequences // Am. J. Clin. Nutr. 2008. Vol. 87. P. 1080S-1086S.][Holick M. F. Vitamin D Deficiency // N. Engl. J. Med. 2007. Vol. 357. P. 266-281.][Lips P. Worldwide status of vitamin D nutrition // J. Steroid. Biochem. Mol. Biol. 2010. Vol. 121, N 1-2. Р 297-300.][Nikooyeh B., Neyestani T. R. Oxidative stress, type 2 diabetes and vitamin D: past, present and future // Diabetes Metab Res Rev. 2016. Vol. 32, N 3. Р 260-267.][Palaniswamy S., Williams D., Järvelin M. R., Sebert S. Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective // Nutr. Metab. Insights. 2016. Vol. 8, suppl. 1. P. 11-21. doi: 10.4137/NMI. S29526. eCollection 2015.][Thorne-Lyman A., Fawzi W. W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis // Paediatr. Perinat. Epidemiol. 2012. Vol. 26, suppl 1. P. 75-90. doi: 10.1111/j.1365-3016.2012.01283.x.][Webb A. R., Kline L., Holick M. F. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin // J. Clin. Endocrinol. Metab. 1988. Vol. 67. P 373-378.]