Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)1728-08692949-1444Eco-Vector1675010.33396/1728-0869-2017-11-34-41Research ArticleEXPOSURE TO TOXIC METALS DURING PREGNANCY AND OVERALL WEIGHT-GROWTH CHARACTERISTICS OF THE NEWBORN: SURVEY RESULTS IN MOSCOW REGIONIlchenkoI NI. M. Sechenov First Moscow State Medical University of the Russian Ministry of Healthirinailchenko9@gmail.comBoyarskayaT VI. M. Sechenov First Moscow State Medical University of the Russian Ministry of Health-LyapunovS MGeological Institute of the Russian Academy of Sciences-OkinaO IGeological Institute of the Russian Academy of Sciences-151120172411344123102019Copyright © 2017, Human Ecology2017A human biomonitoring survey of 120 women in birth from six maternity hospitals of Moscow region was carried out on a standard methodology of the World Health Organization. Prenatal exposure to lead, cadmium, mercury and arsenic was characterized by low levels: the geometric mean for mercury in maternal hair was 0.21 |jg/g; for mercury in umbilical cord blood - 0.89 |jg/l; for mercury in maternal urine - 0.27 |jg/l, which correspond approximately to the levels in European countries with a relatively low consumption of fish. The average content of lead in cord blood was equal to 7.96 |jg/L, and the total arsenic and cadmium in concentrations in the urine - 0.20 |jg/L and 21.9 |jg/L respectively. Of all toxic metals were established direct and significant associations between lead in cord blood and newborn's weight and height, and negative - between lead in cord blood and cephalization index. Weight and growth characteristics of newborns were also significantly influenced by gestational age, body weight gain of the mother during pregnancy, by newborn's gender. Cephalization index, along with weight and height characteristics of newborns, is an informative indicator that can be used to analyze the relationship between prenatal exposure to heavy metals and neonatal development.mercurycadmiumleadarsenicprenatal exposurehuman biomonitoringhairurineumbilical cord bloodртутькадмийсвинецмышьякпренатальное воздействиебиомониторинг человекаволосымочапуповинная кровь[Биомониторинг человека: факты и цифры. Копенгаген: Европейское региональное бюро ВОЗ, 2015. URL: http:// www.euro.who.int/__data/assets/pdf_file/0007/276388/ Human-biomonitoring-facts-figures-ru.pdf (дата обращения: 12.09.2016).][Горобец П. Ю., Ильченко И. Н. Распространенность экологически зависимых нарушений нервно-психического развития у детей в возрасте 4 - 7 лет при хроническом воздействии тяжелых металлов в малых дозах // Профилактическая медицина. 2005. Т. 8, № 1. C. 14-20.][Ильченко И. Н., Ляпунов С. М., Матвеева С. В., Деев А. Д., Окина О. И., Горобец П. Ю. Методы диагностики экологически зависимых отклонений в нервно-психическом развитии детей. М.: Терра, 2004. 52 c.][Al-Saleh, Shinwari N., Mashhour A. et al. Birth outcome measures and maternal exposure to heavy metals (lead, cadmium and mercury) in Saudi Arabian population // Int J of Hygiene and Environmental Health. 2014. Vol. 217, N 2-3. Р 205-218.][Bellanger M., Pichery C., Aerts D. et al. Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention // Environment Health. 2013. Vol. 12. P. 3-14.][CDC Advisory Committee on Childhood Lead Poisoning Prevention. Low level lead exposure harms children: a renewed call for primary prevention. Atlanta, GA: US Department of Health and Human Services, CDC, 2012. URL: http://www. cdc.gov/nceh/lead/acclpp/final_document_030712.pdf (дата обращения: 12.09.2016).][Choi H., Rauh V., Garfinkel R., Tu Y., Perera F. P. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction // Environmental Health Perspectives. 2008. Vol. 116, N 5. P. 658-665.][The Fourth National Report on Human Exposures to Environmental Chemicals. Updated tables, 2013. US Department of Health and Human Services. Centers for Disease Control and Prevention. URL: www.cdc.gov/ exposurereport (дата обращения: 12.09.2016).][Harel S., Tomer A., Barak Y. et al. The cephalization index: a screening device for brain maturity and vulnerability in normal and intrauterine growth retarded newborns // Brain and Development. 1985. Vol. 7 (6). P. 580-584.][Holmes P., James R. A. F., Levy L. S. Is low-level environmental mercury exposure of concern to human health? // Sci. Total Environ. 2009. Vol. 408. P. 171-182.][Jedrychowski W., Perera F., Jankowski J. et al. Prenatal low-level lead exposure and developmental delay of infants at age 6 months // Int J Hyg Environ Health. 2008. Vol. 211. P. 345-351.][Leitner Y., Fattal-Valevski A., Geva R. et al. Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study // Journal of Child Neurology. 2007. Vol. 22, N 5. P. 580-587.][National Research Council. Toxicological effects of methylmercury. Washington, DC: National Academies Press, 2000.][Obi E., Orisakwe O. E., Okafor Ch. et al. Towards Prenatal Biomonitoring in Eastern Nigeria: Assessing Lead levels and Anthropometric Parameters of Newborns // J UOEH. 2014. Vol. 36, N 3. P 159-170.][Osman K., Akesson A., Berglund M. et al. Toxic and essential elements in placentas of Swedish women // Clin. Biochem. 2000. Vol. 33. P 131-138.][Polanska K., Hanke W., Sobala W., Brze'znicki S., Ligocka D. Exposure to polycyclic aromatic hydrocarbons and newborn biometric indicators // International Journal of Occupational Medicine and Environmental Health. 2010. Vol. 23, N 4. P 339-346.][Rahman A., Vahter M., Smith A.H. et al. Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh // Am J of Epidemiology. 2008. Vol. 169. P 304-312.][Ramon R., Ballester F., Aguinagalde X. et al. Fish consumption during pregnancy, prenatal mercury exposure and anthropometric measures at birth in a prospective mother-infant cohort study in Spain // Am J of Clin Nutr. 2009. Vol. 90. P. 1047-1055.][Sawi I. R., El Saied M. H. Umbilical cord blood lead levels and pregnancy outcomes // J Pharmac and Tox. 2013. Vol. 8, N 3. P. 98-104.][Schulz C., Wilhelm M., Heudorf U., Kolossa-Gehring. Reprint of „Update of the reference and HBM values derived by the German Human Biomonitoring Comission“// Int. J. Hygiene Env. Health. 2012. Vol. 215. P. 150-158.][Wells P. G., Lee C. J., McCallum G. P. et al. Receptor- and Reactive Intermediate-Mediated mechanisms of Teratogenesis. In: Adverse Drug Reactions, Utrecht. 2010. P. 131-162.]