Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)1728-08692949-1444Eco-Vector1680510.33396/1728-0869-2017-5-42-46Research ArticleANTIBODIES, SPECIFIC TO BENZO[A]PYRENE AND ESTRADIOL, IN HEALTHY MEN AND LUNG CANCER PATIENTSGlushkovA NInstitute of Human Ecology-PolenokE GInstitute of Human Ecologyegpolenok@mail.ruKostyankoM VInstitute of Human Ecology-TitovV A-VafinI A-RagozhinaS E-The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Institute of Human EcologyKemerovo State UniversityThe Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of SciencesRegional clinical oncology hospitalRegional center of blood15052017245424623102019Copyright © 2017, Human Ecology2017It is known that the polycyclic aromatic hydrocarbons, particularly benzo[a]pyrene (Bp), are the most common initiators of carcinogenesis, and estradiol (Es) is the most studied endogenous promoter. However, specific immune responses to exogenous and endogenous carcinogenic factors are still insufficiently studied. This paper presents the results of research of antibodies class A and G (IgA and IgG), specific to Bp and Es, in serum of 272 healthy men and 380 patients with non-small cell lung cancer (NSCLC) using a semi-quantitative immunoassay. The purpose of research - to identify the features of antibodies to Bp and Es in NSCLC patients according to the possible individual combinations of their levels in serum. The separated increasing of IgA and IgG antibodies to BP or to Es were found in NSCLC patients more often then in healthy donors (OR = 1,6-1,8). These differences were more significant at the simultaneous increasing of IgA and IgG antibodies to Bp and Es. Probably, induction of specific immunity against exogenous chemical carcinogens and endogenous steroids take part in initiation and promotion of carcinogenesis in human. 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