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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17328</article-id><article-id pub-id-type="doi">10.17816/humeco17328</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">HUMAN PROTEIN BLOOD COUNT DISORDERS UNDER IMPACT OF AROMATIC HYDROCARBONS</article-title><trans-title-group xml:lang="ru"><trans-title>НАРУШЕНИЯ БЕЛКОВОГО СОСТАВА КРОВИ ЧЕЛОВЕКА В УСЛОВИЯХ ВОЗДЕЙСТВИЯ АРОМАТИЧЕСКИХ УГЛЕВОДОРОДОВ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zaytseva</surname><given-names>N V</given-names></name><name xml:lang="ru"><surname>Зайцева</surname><given-names>Н В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zemlyanova</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Землянова</surname><given-names>Марина Александровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, зав. отделом биохимических и цитогенетических методов диагностики</p></bio><email>zem@fcrisk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tarantin</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Тарантин</surname><given-names>А В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Scientific Center for Medical and Preventive Health Risk Management Technologies</institution></aff><aff><institution xml:lang="ru">Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2013</year></pub-date><volume>20</volume><issue>7</issue><issue-title xml:lang="en">NO7 (2013)</issue-title><issue-title xml:lang="ru">№7 (2013)</issue-title><fpage>15</fpage><lpage>26</lpage><history><date date-type="received" iso-8601-date="2019-10-23"><day>23</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Ekologiya cheloveka (Human Ecology)</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Экология человека</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Ekologiya cheloveka (Human Ecology)</copyright-holder><copyright-holder xml:lang="ru">Экология человека</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/17328">https://hum-ecol.ru/1728-0869/article/view/17328</self-uri><abstract xml:lang="en"><p>The review considers the influence of the most common aromatic hydrocarbons (benzene, toluene, styrene, xylene) polluting the environment and being a risk factor for various health disorders, including metabolic changes in the protein profile of the human body.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре рассмотрено влияние воздействия наиболее распространённых ароматических углеводородов (бензол, толуол, ксилол, стирол), загрязняющих объекты среды обитания и являющихся фактором риска развития различных нарушений состояния здоровья, на изменение белкового профиля организма человека.</p></trans-abstract><kwd-group xml:lang="en"><kwd>proteome</kwd><kwd>protein markers</kwd><kwd>benzene</kwd><kwd>toluene</kwd><kwd>xylene</kwd><kwd>styrene</kwd><kwd>environmental exposure</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>протеом</kwd><kwd>белковые маркеры эффекта</kwd><kwd>бензол</kwd><kwd>толуол</kwd><kwd>ксилол</kwd><kwd>стирол</kwd><kwd>внешнесредовая экспозиция</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Бандман А. Л., Войтенко Г. А., Волкова Н. В. и др. Вредные химические вещества. Галоген- и кислородсодержащие органические соединения: справочное издание / под ред. В. А. Филова и др. СПб.: Химия, 1994. С. 688.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>ГОСТ 12.1.007-76. Система стандартов безопасности труда. Вредные вещества. Классификация и общие требования безопасности. М.: ИПК Издательство стандартов, 2002.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Куценко С. А. Основы токсикологии. СПб., 2004. С. 720.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Онищенко Г. Г., Зайцева Н. В., Землянова М. А. Гигиеническая индикация последствий для здоровья при внешнесредовой экспозиции химических факторов. Пермь: Книжный формат, 2001. С. 124.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Al-Ghamdi S. S., Raftery М. J., Yaqoob М. M. Organic solvent-induced proximal tubular cell toxicity via caspase-3 activation // J. Toxicol. Clin. Toxicol. 2003. N 41. P. 967-971.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Al-Ghamdi S. S., Raftery M. J., Yaqoob М. M. Acute solvent exposure induced activation of cytochrome P4502E1 causes proximal tubular cell necrosis by oxidative stress // Toxicology in Vitro. 2003. N 17(3). P. 335-341.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Al-Ghamdi S. S., Raftery M. J., Yaqoob М. M. Organic solvent-induced proximal tubular cell apoptosis via caspase-9 activation // Environmental Toxicology and Pharmacology. 2004. N 16(3). P. 147-152.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Atkinson T. J. A review of the role of benzene metabolites and mechanisms in malignant transformation: summative evidence for a lack of research in nonmyelogenous cancer types // Int. J. Hyg. Environ. Health. 2009. N 212(1). P. 1-10.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Barreto G., Madureira D., Capani F., Aon-Bertolino L., Saraceno E., Lisandro D. A.-G. The Role of Catechols and Free Radicals in Benzene Toxicity: An Oxidative DNA Dam age Pathway // Environmental and Molecular Mutagenesis. 2009. N 50. P. 771-780.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Chen K., Gunter K., Maines M. D. Neurons overex-pressing heme oxygenase-1 resist oxidative stress-mediated cell death // J. Neurochem. 2000. N 75. P. 304-313.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Croute F., Gaubin Y., Beau B., Simon V., Murat J. C., Soleilhavoup J. P. Volatile organic compounds cytotoxicity and expression of HSP72, HSP90 and GRP78 stress proteins in ultured human cells // Biochimica et Biophysica Acta. 2002. N 1591. P. 147-155.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Eastmond D. A., Mondrala S. T., Hasegawa L. Topoisomerase II inhibition by myeloperoxidase-activated hy-droquinone: A potential mechanism underlying the genotoxic and carcinogenic effects of benzene // Chemico-Biological Interactions. 2005. N 153-154. P. 207-216.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Fischäder G., Röder-Stolinski C., Wichmann G., Nieber К., Lehmann I. Release of MCP-1 and IL-8 from lung epithelial cells exposed to volatile organic compounds // Toxicology in Vitro. 2008. N 22 (2). P. 359-366.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Forrest M. S., Lan Q., Hubbard A. E., Zhang L., Vermeulen R., Zhao X., Li G., Wu Yen-Ying, Shen M., Yin S., Chanock S. J., Rothman N., Smith M. T. Discovery of Novel Biomarkers by Microarray Analysis of Peripheral Blood Mononuclear Cell Gene Expression in Benzene-Exposed Workers // Environmental Health Perspectives. 2005. N 113(6). P. 801-807.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Gillis B., Gavin I. M., Arbieva Z., King S. T., Jayaraman S., Prabhakar B. S. Identification of human cell responses to benzene and benzene metabolites // Genomics. 2007. N 90. P. 324-333.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Giuliano M., Stellavato A., Cammarota M., Lamberti M., Miraglia N., Sannolo N., De Rosa M. Effects of low concentrations of benzene on human lung cells in vitro // Toxicology Letters. 2009. N 188. P. 130-136.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Hartwig A. The role of DNA repair in benzene-induced carcinogenesis // Chemico-Biological Interactions. 2010. N 184(1-2). P. 269-272.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>IARC Monographs on Evaluation Carcinogenic Risks in Humans, in: IARC (Ed.), Some Traditional Herbal Medicines, Some Mycotoxins, Naphtalene and Styrene // IARC, Lyon. 2002. N 82. P. 437-522.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>IARC, Monographs on Evaluation of Carcinogenic Risks to Humans: Printing processes (Occupational exposure Group 2B) and printing inks (Group 3) // International Agency for Research on Cancer. 1996. N 65. P. 33—149.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>IARC, Monographs on the Evaluation of Carcinogenic Risk to Humans, Toluene, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide // Agency for Research on Cancer, World Health Organization, Lyon. 1999. N 71. P. 829-864.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>IARC, Monographs on the Evaluation of Carcinogenic Risk to Humans, Xylenes, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide // Agency for Research on Cancer, World Health Organization, Lyon. 1999. N 71. P. 1189-1208.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Laffon B., Pasaro E., Mendez J. Effects of styrene- 7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures // Mutagenesis. 2001. N 16(2). P. 127-132.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Lindbohm M. L., Taskinen H., Sallmen M., Hemminki K., Spontaneous abortions among women exposed to organic solvents // Am. J. Ind. Med. 1990. N 17. P. 449-463.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>McHale C. M., Zhang L., Lan Q., Li G., Hubbard A. E., Forrest M. S., Vermeulen R., Chen J., Shen M., Rappaport S. M., Yin S., Smith M. T., Rothman N. Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms // Genomics. 2009. N 93(4). P. 343-349.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Monographs on the Evaluation of Carcinogenic Risks to Humans Overall Evaluations of Carcinogenicity // International Agency for Research on Cancer (IARC). 1987. An Updating of IARC Monographs.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mörbt N., Mögel I., Kalkhof S., Feltens R., Röder-Stolinski C., Zheng J., Vogt C., Lehmann I., von Bergen M. Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism // PROTEOMICS. 2009. N 9(21). P. 4920-4933.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Nakajima T., Wang R. S., Elovaara E. et al. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively // Biochem. Pharmacol. 1994. N 48. P. 637-642.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Otterbein L. E., Soares M. P., Yamashita K., Bach F. H. Heme oxygenase-1: unleashing the protective properties of heme // Trends Immunol. 2003. N 24. P. 449—455.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Ouyang Y., Virasch N., Hao P. et al. Suppression of human IL-1 beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts // J. Allergy Clin. Immunol. 2000. N. 106. P. 280-287.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Park K., Cho S. Y., Kim H., Paik Y. Proteomic alterations of the variants of human aldehydedehydrogenase isozymes correlate with hepatocellular carcinoma // Int. J. Cancer. 2002. N 97. P. 261-265.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Paustenbach D. J., Bass R. D., Price P. Benzene toxicity and risk assessment, 1972—1992: implications for future regulation // Environ. Health Perspect. Suppl. 1993. N 101. P. 177-200.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Pedersen-Bjergaard J., Andersen M. K., Andersen М. T., Christiansen D. H. Genetics of therapy-related myelodysplasia and acute myeloid leukemia // Leukemia. 2008. N 22. P. 240-248.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Rappaport S. M., Yeowell-O’Connell K., Protein adducts as dosimeters of human exposure to styrene, styrene- 7,8-oxide, and benzene // Toxicology Letters. 1999. N 108. P. 117-126.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ross D., Siegel D., Schattenberg D. G., Sun X. M., Moran J. L. Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity // Environ. Health Perspect. 1996. N 104(6). P. 1177-1 182.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Ross D. Functionsand distribution of NQOl inhuman bone marrow: Potential clues to benzene toxicity // Chemico-Biological Interactions. 2005. N 153-154. P. 137-146.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Rueff J., Teixeira J. P., Silva Santos Luis, Gaspar J. F. Genetic effects and biotoxicity monitoring of occupational styrene exposure // Clinica Chimica Acta. 2009. N 399 (1-2). P. 8-23.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Sailendra N. S., Youn-Jung K., Jae-Chun R. Gene expression profiles of human promyelocytic leukemia cell lines exposed to volatile organic compounds // Toxicology. 2010. N 271(3). P. 122-130.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Sailendra N. S., Youn-Jung K, Mee S., Jae-Chun R. Induction of apoptosis in human leukemia cells through the production of reactive oxygen species and activation of HMOX1 and Noxa by benzene, toluene, and o-xylene // Toxicology. 2011. N 280(3). P. 109-117.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Shield A. J., Sanderson B. J. S. Role of glutathione-S-transferase mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity // Environ. Mol. Mutagen. 2001. N 37. P. 285-289.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Shield A. J., Sanderson B. J. S. A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity // Toxicology. 2004. N 195(1). P. 61—68.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Sliwinska-Kowalska M., Prasher D., Rodrigues C. A., Zamyslowska-Szmytke E., Campo P., Henderson D., Lund S. P., Johnson A. C., Schaper M., Odkvist L., Starch J., Toppila E., Schneider E., Möller C., Fuente A., Gopal К.V. Ototoxicity of organic solvents - from scientific evidence to health policy // International Journal of Occupational Medicine and Environmental Health. 2007. N 20. P. 215—222.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Smith М. T. The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia // Environ. Health Perspect. 1996. N 104(6). P. 1219-1225.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Smith М. T., Zhang L., Wang Y. et al. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene // Cancer Res. 1998. N 58. P. 2176-2181.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Smith М. T., Zhang L., Wang Y., Hayes R. B., Li G., Wiemels J., Dosemeci M., Titenko-Holland N., Xi L., Kolachana P., Yin S., Rothman N. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene // Cancer Res. 1998. N 58. P. 2176-2181.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Snyder R., Hedli C. C. An overview of benzene metabolism // Environ. Health Perspect. 1996. N 104(6). P. 1165-1171.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Spatari G., Saitta S., Cimino F., Sapienza D., Quattrocchi P., Carrieri M., Barbaro M., Saija A., Gangemi S. Increased serum levels of advanced oxidation protein products and glycation end products in subjects exposed to low-dose benzene // International Journal of Hygiene and Environmental Health. 2012. N 215(3). P. 389-392.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Subrahmanyam V. V., Ross D., Eastmond D. A., Smith M. T. Potential role of free radicals in benzene-induced myelotoxicity and leukemia // Free Radiс. Biol. Med. 1991. N 11. P. 495-515.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Sumner J. S., Fennell T. R. Review of the metabolic fate of styrene // Crit. Rev. Toxicol. 1994. N 24. P. 11—33.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Terenzi F., Hui D. J., Merrick W. C., Sen G. C. Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56 // J. Biol. Chem. 2006. N 281. P. 34064-34071.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Won-А J., Donggeun S., Do-Youn L., Eunil Lee, Chan-Wha Kim. Proteomic analysis of plasma proteins of workers exposed to benzene. // Mutation Research. 2004. № 558. P. 35-44.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Yeowell-O’Connell K., Jin Z., Rappaport S. M. Determination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide // Cancer Epidemiol. Biomarkers Prev. 1996. N 5. P. 205-215.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Yongyi Bi, Yuhong Li, Mengmeng Kong, Xiao Xiao, Zhiwei Zhao, Xiaoqing He, Qiang Ma. Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: Induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair // Chemico-Biological Interactions. 2010. N 184(1-2). P. 207-211.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Yoon B. I., Hirabayashi Y., Kawasaki Y. et al. Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity // Toxicol. Sсi. 2002. N 7. P. 150-156.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Zhang L., Eastmond D. A., Smith M. T. The nature of chromosomal aberrations detected in humans exposed to benzene // Crit. Rev. Toxicol. 2002. N 32. P. 1—42.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Zhang L., Rothman N., Wang Y. et al. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene // Carcinogenesis. 1998. N 19. P. 1955—1961.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Zhang L., Smith M., Bandy B., Tamaki S. J., Davison A. J. Role of Quinones, active oxygen species and metals in the genotoxicity of 1,2,4-benzenetriol, a metabolite of benzene. H. Nhol, H. Esterbauer, C. Rice-Evans (Eds.) // Free Radicals in the Environment, Medicine and Toxicology. Richelieu, London. 1994. P. 521—562.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Zhenlie H., Hailan W., Hanlin H., Lihua X., Cishan Ch., Xinxiang Q., Jiabin Ch., Susheng Ch., Weihui L., Ming H., Li L., Qianling Zh., Banghua Wu, Guanchao L. iTRAQ-based proteomic profiling of human serum reveals down-regulation of basic protein and apolipoprotein B100 in patients with hematotoxicity platelet by chronic occupational benzene exposure induced. // Toxicology. 2012. N 291. P. 56-64.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Zong W. X., Lindsten T., Ross A. J., MacGregor G. R., Thompson C. B. ВНЗ-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak// Genes Dev. 2001. N 15. P. 1481-1486.</mixed-citation></ref></ref-list></back></article>
