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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17439</article-id><article-id pub-id-type="doi">10.17816/humeco17439</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">VIOLATIONS OF HUMAN PROTEIN PROFILE IN HEAVY METALS EXPOSURE</article-title><trans-title-group xml:lang="ru"><trans-title>Нарушения белкового профиля человека в условиях воздействия тяжелых металлов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zemlyanova</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Землянова</surname><given-names>Марина Александровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, зав. отделом биохимических и цитогенетических методов диагностики</p></bio><email>zem@fcrisk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tarantin</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Тарантин</surname><given-names>А В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia</institution></aff><aff><institution xml:lang="ru">Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения, г. Пермь</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2012</year></pub-date><volume>19</volume><issue>7</issue><issue-title xml:lang="en">NO7 (2012)</issue-title><issue-title xml:lang="ru">№7 (2012)</issue-title><fpage>7</fpage><lpage>14</lpage><history><date date-type="received" iso-8601-date="2019-10-23"><day>23</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Zemlyanova M.A., Tarantin A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Землянова М.А., Тарантин А.В.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Zemlyanova M.A., Tarantin A.V.</copyright-holder><copyright-holder xml:lang="ru">Землянова М.А., Тарантин А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/17439">https://hum-ecol.ru/1728-0869/article/view/17439</self-uri><abstract xml:lang="en"><p>The review considers influence of exposure of the most common heavy metals (lead, chromium, cadmium, manganese, nickel, vanadium) polluting the environment and being a risk factor of various health disorders progress, including metabolic changes in the protein profile of the human body.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре рассмотрено влияние воздействия наиболее распространённых тяжёлых металлов (свинец, хром, кадмий, марганец, никель, ванадий), загрязняющих объекты среды обитания и являющихся фактором риска развития различных нарушений состояния здоровья, в том числе обмена веществ, на изменение белкового профиля организма человека.</p></trans-abstract><kwd-group xml:lang="en"><kwd>proteome</kwd><kwd>protein markers of effects</kwd><kwd>heavy metals</kwd><kwd>environmental exposure</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>протеом</kwd><kwd>белковые маркеры эффекта</kwd><kwd>тяжёлые металлы</kwd><kwd>внешнесредовое воздействие</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Авцын А. 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