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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17512</article-id><article-id pub-id-type="doi">10.17816/humeco17512</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">MODERN CONCEPTS OF THE MECHANISMS FORMING NORTHERN STRESS IN HUMANS IN HIGH LATITUDES</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ ФОРМИРОВАНИЯ СЕВЕРНОГО СТРЕССА У ЧЕЛОВЕКА В ВЫСОКИХ ШИРОТАХ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Hasnulin</surname><given-names>V I</given-names></name><name xml:lang="ru"><surname>Хаснулин</surname><given-names>Вячеслав Иванович</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, руководитель лаборатории механизмов дизадаптации</p></bio><email>hasnulin@ngs.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Hasnulin</surname><given-names>P V</given-names></name><name xml:lang="ru"><surname>Хаснулин</surname><given-names>П В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Scientific Center of Clinical and Experimental Medicine Siberian Branch RAMS</institution></aff><aff><institution xml:lang="ru">Научный центр клинической и экспериментальной медицины Сибирского отделения РАМН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2012</year></pub-date><volume>19</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2012)</issue-title><issue-title xml:lang="ru">№1 (2012)</issue-title><fpage>3</fpage><lpage>11</lpage><history><date date-type="received" iso-8601-date="2019-10-23"><day>23</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Hasnulin V.I., Hasnulin P.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Хаснулин В.И., Хаснулин П.В.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Hasnulin V.I., Hasnulin P.V.</copyright-holder><copyright-holder xml:lang="ru">Хаснулин В.И., Хаснулин П.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/17512">https://hum-ecol.ru/1728-0869/article/view/17512</self-uri><abstract xml:lang="en"><p>The extreme climatic and geographical northern conditions cause a human northern stress (“the polar tension syndrome”). The main components of this syndrome are an oxidative stress, failure of detoxication processes and barrier organs, disorders of the northern metabolism, the northern tissue hypoxia, immune insufficiency, blood hypercoagulation, polyendocrine disorders, regenerative and plastic failure, electromagnetic homeostasis disorders, functional dissymmetry of interhemispheric interrelations, desynchronosis, psychoemotional tension, meteopathia. It has been shown that chronic stress caused organism reserve exhaustion leading to development of some dysaptative disorders and pathological states.</p></abstract><trans-abstract xml:lang="ru"><p>Суровые климатогеофизические условия северных широт становятся причиной развития у человека северного стресса («синдром полярного напряжения»). Основными составляющими звеньями этого полисиндрома являются: окислительный стресс, недостаточность детоксикационных процессов и барьерных органов, расстройства северного типа метаболизма, северная тканевая гипоксия, иммунная недостаточность, гиперкоагуляция крови, полиэндокринные расстройства, регенераторно-пластическая недостаточность, нарушения электромагнитного гомеостаза, функциональная диссимметрия межполушарных взаимоотношений, десинхроноз, психоэмоциональное напряжение, метеопатия. Показано, что хронический стресс вызывает истощение резервных возможностей организма, что в последующем довольно часто приводит к развитию каскада дизадаптивных расстройств, а позже к возникновению патологических состояний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>environmentally caused northern stress</kwd><kwd>adaptation of a man in the North</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>экологически обусловленный северный стресс</kwd><kwd>адаптация человека на Севере</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Aizman R. I. Funktsional'noe sostoyanie pochek i vodnosolevogo obmena u detei, stradayushchikh ostroi pnevmoniei [Kidney functional state and water-salt metabolism in children suffering from acute pneumonia] // Problemy zdorov'ya naseleniya regionov Krainego Severa, Sibiri, Dal'nego Vostoka. Krasnoyarsk, 1986. S. 72-74. [in Russian]</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Berezin F. B. Psikhicheskaya adaptatsiya i psikhofiziologicheskie sootnosheniya [Mental adaptation and psychophysiological correlations] // Nauchno-tekhnicheskii progress i pripolyarnaya meditsina. Novosibirsk. 1978. T. 1. S. 260-261. [in Russian]</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Boiko E. R. Fiziologo-biokhimicheskie osnovy zhiznedeyatel'nosti cheloveka na Severe [Physiological-biochemical principles of human vital activity in the North]. Yekaterinburg, 2005. 190 s. [in Russian]</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Deryapa N. R, Matusov A. L, Ryabinin I. F. Adaptatsiya cheloveka k ekstremal'nym usloviyam Antarktidy [Human adaptation to extreme Antarctic conditions] // Resursy Biosfery. 3. Adaptatsiya cheloveka. L.: Nauka, 1976. S. 120-143. [in Russian]</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Dobrodeeva L. K., Sen'kova L. V., Moskovskaya N. B. Ekologicheski zavisimye izmeneniya immuniteta na Severe [Ecologically dependent immunity changes in the North] // Fiziologicheskie zakonomernosti gormonal'nykh, metabolicheskikh, immunologicheskikh izmenenii v organizme cheloveka na Evropeiskom Severe. Syktyvkar, 1997. S. 97-117. [in Russian]</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Zhmurov V. A., Oskolkov S. A., Kazeko N. I. Khronicheskii pielonefrit u zhitelei razlichnykh klimatogeograficheskikh regionov. Kliniko-biokhimicheskie i immunologicheskie aspekty [Chronic pyelonephritis in residents of different climatogeographic regions. Clinical-biochemical and immunological aspects]. Tyumen: Akademiya, 2006. 304 s. [in Russian]</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Zaitsev A. N. Gigienicheskaya kharakteristika fakticheskogo pitaniya naseleniya Krainego Severa [Hygienic characteristic of actual nourishment of the Far North population] // Problemy Severa. Vyp. 14. Trud i zdorov'e cheloveka na Krainem Severe. M.: Nauka, 1970. S. 198-203. [in Russian]</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kaznacheev V. P. Mekhanizmy adaptatsii cheloveka v usloviyakh vysokikh shirot [Human adaptation mechanisms in high latitudes conditions]. L.: Meditsina, 1980. 200 s. [in Russian]</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Korolenko Ts. P. Psikhofiziologiya cheloveka v ekstremal'nykh usloviyakh [Human psychophysiology in extreme conditions]. L.: Meditsina, 1978. 272 s. [in Russian]</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Korolenko Ts. P., Bochkareva N. L. Osobennosti nekotorykh ekzogennykh intoksikatsii v usloviyakh Severa [Features of some exogenic intoxications in Northern conditions]. Novosibirsk, 1982. 120 s. [in Russian]</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kochetkova G. V. Sostoyanie gemokoagulyatsii u lits, prozhivayushchikh v raznykh naselennykh punktakh YaASSR [Clotting state in persons living in different settlements of the Yakut Autonomous Soviet Socialist Republic] // Biologicheskie problemy Severa. Ch. 3. Magadan, 1983. S. 108-109. [in Russian]</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kulikov V. Ju., Safronov I. D. Reakcii perekisnogo okislenija lipidov pri adaptacii indijskih voennosluzhashhih v rajonah Krajnego Severa i posledujushhej readaptacii v tropikah [Reactions of free-radical oxidation in flights to the Arctic Circle] // Mediko-jekologicheskie aspekty adaptacii zhitelej tropikov v Arktike (po materialam sovetsko-indijskogo eksperimenta). Novosibirsk: SO RAMN. 1994. T. 2. S. 230257. [in Russian]</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Leutin V. P., Nikolaeva E. N. Psikhofiziologicheskie mekhanizmy adaptatsii i funktsional'naya asimmetriya mozga [Psychophysiological mechanisms of adaptation and the brain functional asymmetry]. Novosibirsk: Nauka, 1988. 193 s. [in Russian]</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Nepomnyashchikh L. M., Lushnikova E. L., Semenov D. E. Regeneratorno-plasticheskaya nedostatochnost' serdtsa: morfologicheskie osnovy i molekulyarnye mekhanizmy [Regeneration-plastic cardiac insufficiency: morphological principles and molecular mechanisms]. M.: Izd-vo RAMN, 2003. 255 s. [in Russian]</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Nepomnyashchikh L. M. Regeneratorno-plasticheskaya nedostatochnost' serdtsa: molekulyarno-biologicheskie mekhanizmy i morfologicheskie osnovy [Regeneration-plastic cardiac insufficiency: molecular-biological mechanisms and morphological principles] // Arkhiv patologii. 2007. T. 65, N 3. S. 3-12. [in Russian]</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Pavlenko Yu. S. Osobennosti vremennykh kharakteristik funktsii organizma cheloveka v usloviyakh ekologicheskogo neblagopoluchiya [Features of time characteristics of human body functions in conditions of ecological ill-being]: avtoref. dis. ... kand. biol. nauk. Novosibirsk, 2003. 23 s. [in Russian]</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Panin L. E. Biokhimicheskie mekhanizmy stressa [Stress biochemical mechanisms]. Novosibirsk: Nauka, 1983. 231 s. [in Russian]</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Sevost'yanova E. V., Khasnulin V. I. Gendernye razlichiya ustoichivosti k prirodnym faktoram Sibiri v zavisimosti ot tipa funktsional'noi mezhpolusharnoi asimmetrii [Gender differences in resistance of young siberians to natural factors depending on type of functional interhemispheric assymmetry] // Ekologiya cheloveka [Human Ecology]. 2011. N 1. S. 14-18. [in Russian]</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Sobakin A. K. Rabotosposobnost' vakhtovogo personala gazovykh promyslov v ekstremal'nykh ekologicheskikh usloviyakh Severa [Working ability of rotation personnel in gasfields in northern extreme ecological conditions]: avtoref. dis... kand. biol. nauk. Novosibirsk, 2004. 30 s. [in Russian]</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Stepanov Yu. M. Rol' funktsional'noi asimmetrii mozga v regulyatsii psikhofiziologicheskogo sostoyaniya cheloveka pri adaptatsii k usloviyam Krainego Severa [Role of the brain functional asymmetry in regulation of human psychophysiological status during adaptation to the Far North conditions]: avtoref.dis. ... kand. biol. nauk. Novosibirsk, 1988. 23 s. [in Russian]</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Hasnulin V. I., Sobakin A. K., Hasnulin P. V., Boj-ko E. R. Podhody k rajonirovaniju territorij Rossii po uslovijam diskomfortnosti okruzhajushhej sredy dlja zhiznedejatel'nosti naselenija [Approaches to classification of the Russian territories according to the conditions of environmental discomfort for population vital activity] // Bjulleten' SO RAMN. 2005. N 3 (117). S. 106-111. [in Russian]</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Hasnulin V. I. Vvedenie v polyarnuyu meditsinu [Introduction into Polar Medicine]. Novosibirsk: SO RAMN, 1998. 337 s. [in Russian]</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Hasnulin V. I., Hasnulina A. V., Chechetkina I. I. Severnyi stress, formirovanie arterial'noi gipertenzii na Severe, podkhody k profilaktike i lecheniyu [The northern stress, arterial hypertension in the North, approach to prophylaxis and treatment] // Ekologiya cheloveka [Human Ecology]. 2009. N 6. S. 26-30. [in Russian]</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Hasnulina A. V., Hasnulin V. I., Kolosova O. A. Nedostatochnost' adaptivnykh mekhanizmov i prezhdevremennoe starenie cheloveka na Krainem Severe [Adaptive mechanisms insufficiency and human premature ageing in the Far North] // Adaptatsiya cheloveka v razlichnykh klimato-geograficheskikh i proizvodstvennykh usloviyakh. Novosibirsk, 1981. T. 3. S. 87-88. [in Russian]</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Hasnulina A. V., Hasnulin V. I. Vliyanie psikhoemotsional'nogo stressa na adaptatsionno-vosstanovitel'nyi potentsial cheloveka v usloviyakh vakhtovogo truda na Severa [Effect of psychoemotional stress on human adaptive-regenerative potential under shift work conditions in the North] // Ekologiya cheloveka [Human Ecology]. 2010. N 12. S. 18-22. [in Russian]</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Chechetkina I. I. Osobennosti protsessov stareniya trudosposobnogo naseleniya na Severe [Features of ageing processes of working population in the North]: avtoref. dis. . kand. med. nauk. Novosibirsk, 2007. 25 s. [in Russian]</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Shorin Yu. P., Lepeluotto Yu. Gormonal'noe obespechenie prisposobitel'nykh reaktsii v usloviyakh Severa [Hormonal provision of adaptive reactions in northern conditions] // Klinicheskie aspekty polyarnoi meditsiny. M.: Meditsina, 1986. S. 57-68. [in Russian]</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Boulos Z. Seasonal Mood and Sleep Disorders at High Latitudes. Health and Social Problems of the Development of Oil and Gas Field in Arctic Regions. Nadym, Russia, 1993. Р. 5.1-5.5.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Jorgensen E. H., Vijayan M. M., Killie J.E., Aluru N., Aas-Hansen O., Maule A. Toxicokinetics and effects of PCBs in Arctic fish: a review of studies on Arctic charr . J. Toxicol Environ. Health. 2006. Vol. 69(1-2). Pp. 37-52.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Hasnulin V. I., Hasnulina A. V., Sevostyanova E. V. Northern cardiometeopathies. Novosibirsk: Creative Union “South-West”, 2004. 220 p.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Hasnulin V. I. Geophysical pertubations as the main cause of northern human stress. Alaska Med. 2007. Vol. 49 (2 Suppl.). P. 237-244.</mixed-citation></ref></ref-list></back></article>
