Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)Экология человека1728-08692949-1444Eco-Vector32119010.17816/humeco321190REVIEWSОБЗОРЫReview ArticleDanio rerio as a model for studying reproductive risks associated with human exposure to polychlorinated biphenils: a systematic reviewDanio rerio как модель изучения репродуктивных рисков, связанных с воздействием полихлорированных бифенилов на людей (систематический обзор)https://orcid.org/0000-0002-1216-933557210162204ABF-3591-20208124-3660KotsurDmitry A.КоцурДмитрий Александрович
Russian Federation

Cand. Sci. (Legal)

инженер

mitia.kotsur@yandex.ruhttps://orcid.org/0000-0002-4873-87471813-7323SorokinaTatyana Yu.СорокинаТатьяна Юрьевна
Russian Federation

Cand. Sci. (Legal)

к.ю.н.

t.sorokina@narfu.ruhttps://orcid.org/0000-0003-1013-13572267-4560AksenovAndrey S.АксеновАндрей Сергеевич
Russian Federation

Cand. Sci. (Tech.), associate professor

к.т.н., доцент

a.s.aksenov@narfu.ruhttps://orcid.org/0000-0002-2600-05226989-1648ChashchinValery P.ЧащинВалерий Петрович
Russian Federation

MD, Dr. Sci. (Med.), professor, head research associate, Institute of Ecology

д.м.н., профессор, главный научный сотрудник, институт экологии

valerych05@mail.ruNorthern (Arctic) Federal University named after M.V. LomonosovСеверный (Арктический) федеральный университет имени М.В. ЛомоносоваN. Laverov Federal Center for Integrated Arctic ResearchФедеральный исследовательский центр комплексного изучения Арктики им. Н.П. ЛавероваNorth-Western State Medical University named after I.I. MechnikovСеверо-Западный государственный медицинский университет имени И.И. МечниковаNSE UniversityНациональный исследовательский университет «Высшая школа экономики»Northwestern Scientific Center for Hygiene and Public HealthСеверо-Западный научный центр гигиены и общественного здоровья18072023150820233042452580903202313062023Copyright ©; 2023, Eco-VectorCopyright ©; 2023, Эко-Вектор2023Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0https://hum-ecol.ru/1728-0869/article/view/321190

This review presents the findings of a comprehensive investigation that involved a systematic search, critical analysis, and synthesis of scientific evidence regarding the impact of a broad range of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), on the reproductive functions, postembryonic survival, and morphofunctional development of offspring in the aquarium fish species Danio rerio, commonly known as Zebrafish. These fish are extensively utilized in experimental studies to simulate carcinogenic, mutagenic, and general toxic effects.

The literature search was conducted using Web of Science, Scopus, PubMed, and eLIBRARY.RU databases following the PRISMA 2020 recommendations. A total of 613 articles were identified, out of which 14 were selected for detailed analysis. Among them, 11 focused on assessing the impact of PCB exposure on the reproductive system of Danio rerio. Additionally, 8 articles reported on the results of studying the effects of parental exposure to PCBs on the viability and postembryonic development of their offspring. The adverse effects of PCBs, either alone or in combination with other POPs, have been studied to a lesser extent in male Danio rerio compared to females. Furthermore, the transmission of morphological and functional disorders to subsequent generations resulting from separate parental exposure to PCBs in both sexes, as well as the dose-response relationship, have not been adequately assessed based on the published works. Moreover, developmental disorders in offspring have mostly been studied for the first generation following parental exposure to mixtures of POPs and PCBs. The lack of such information hinders a proper evaluation of the transgenerational risk inheritance phenomenon, specifically regarding the transmission of morphological and functional disorders associated with progenitor exposure to PCBs and other environmental endocrine-disrupting pollutants.

The findings of this analysis can be used for planning experimental quantitative assessments, predicting, and preventing impairments to human reproductive health, and safeguarding the well-being of future generations.

Выполненный систематический обзор представляет собой результат поиска, критического анализа и синтеза научных данных о влиянии большого класса стойких органических загрязнителей (СОЗ), включая полихлорированные бифенилы (ПХБ), на репродуктивную функцию, постэмбриональную выживаемость и морфофункциональное развитие потомства у аквариумных рыб Danio rerio, широко используемых в экспериментальных исследованиях для моделирования канцерогенных, мутагенных и общетоксических эффектов.

Поиск литературы осуществляли в международных научных базах данных Web of Science, Scopus, PubMed и eLIBRARY.RU в соответствии с рекомендациями PRISMA 2020. Всего было идентифицировано 613 статей, из которых отобрали 14 статей для детального анализа. В 11 из 14 публикаций были представлены результаты оценки вредного воздействия ПХБ на репродуктивную систему Danio rerio, а в 8 из 14 статьей сообщалось о результатах изучения влияния ПХБ на жизнеспособность и постэмбриональное развитие потомства у подвергнутых такому воздействию родительских особей. Отмечено, что вредное влияние ПХБ или их смесей с другими СОЗ на репродуктивную систему самцов Danio rerio изучено в гораздо меньшей степени, чем у самок. Передача последующим поколениям рисков морфофункциональных нарушений, связанных с раздельным воздействием ПХБ на родительские особи обоих полов, и дозовая зависимость этих эффектов, судя по опубликованным работам, не получили надлежащей оценки. Нарушения развития потомства изучались в основном в первом поколении после экспозиции родительских особей к смесям СОЗ и ПХБ. Недостаток подобных сведений не позволяет осуществить корректную оценку феномена трансгенерационного наследования рисков морфофункциональных нарушений, связанных с воздействием ПХБ и других гормоноподобных экотоксикантов на организм прародителей.

Результаты выполненного анализа могут быть полезны при планировании экспериментальной количественной оценки для прогнозирования и предотвращения нарушений репродуктивного здоровья человека и здоровья будущих поколений.

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