Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)1728-08692949-1444Eco-Vector4714910.33396/1728-0869-2020-10-45-54Research ArticleANTHROPOMETRIC CHARACTERISTICS OF YOUNG ADULTS IN AREAS WITH DIFFERENT ECOLOGICAL RISKS IN THE ARAL SEA REGION, UZBEKISTANYerkudovV. O.verkudov@gmail.ruZaslavskyD. V.-PugovkinA. P.-MatchanovA. T.-RozumbetovK. U.-DauletovR. K.-EsemuratovaS. P.-NazhimovI. I.-PuzyrevV. G.-St. Petersburg State Pediatric Medical UniversityKarakalpak Berdakh State UniversityNukus branch of Tashkent Pediatric Medical Institute151020202710455419102020Copyright © 2020, Yerkudov V.O., Zaslavsky D.V., Pugovkin A.P., Matchanov A.T., Rozumbetov K.U., Dauletov R.K., Esemuratova S.P., Nazhimov I.I., Puzyrev V.G.2020Aim. In this paper we present anthropometric characteristics of young adults permanently living in three areas with different ecological risks in the Aral Sea region. The main hypothesis is that the exposure to organochlorine pesticides (OCPs) in early childhood combined with factor associated with Aral Sea disaster (ASD) may have consequences for body composition in adulthood. Methods. A cross-sectional study. Altogether, 33 anthropometric parameters including body mass, length, sizes of extremities, chest, pelvis, and skinfold thickness were measured in 320 volunteers (135 males, 175 females) born in 1990-1995 before implementation of measures for liquidation of the ASD consequences. The participants were divided into three groups by ecological characteristics of the place of residence: 1 - critical, 2 -relatively optimal and 3 - optimal. Numeric data were analyzed by Kruskal-Wallis tests with Mann-Whitney post-hoc tests with Bonferroni correction for multiple comparisons. Categorical data were compared using exact chi-squared tests for binomial distribution. Results. Young men living in critical area had significantly lower values for body mass, arm length, chest circumference, waist circumference, skinfold thickness compared to their counterparts in other groups. Women from the second group had significantly greater average values for all studied characteristics compared with the two other groups. Conclusions. Men from the most ecologically disadvantaged areas had signs of suboptimal bone development. The observed differences in arm length and the size of the major joints in men may by associated with the anti-androgenic effect of OCPs before and during puberty while the opposite pattern revealed in females may be partly explained by estrogenic effect of OCPs. Our findings are in line with the results from the literature on endocrine disruptor chemicals. Environmental monitoring and public health measures are needed to preserve and improve health of the population of the Aral Sea region.anthropometric parametersyoungstersAral Sea disasterpesticidesendocrine disruptor chemicalsантропометрические параметрыюношидевушкиАральская экологическая катастрофапестицидыэндокрин-разрушающие соединения[Властовский В. Г. Акцелерация роста и развития детей. М.: Изд-во МГУ, 1976. 280 с][Курбанов А. Б., Ещанов Т. Б., Ибрагимов М. Ю., Константинова Л. Г., Темирбеков О. и Косназаров К. А. Гигиеническая оценка пестицидов, применяемых в Республике Каракалпакстан. Нукус: Билим, 2002. 76 с][Матуразова Э. М., Матуразов Б. М., Бегжанова Г. Исследование антропометрических показателей у детей, проживающих в Южном Приаралье // Вестник Каракалпакского отделения Академии наук Республики Узбекистан. 2008. № 1. С. 49-52][Матчанова Н. А., Гаипова Г. Т., Ержепова Г. Ж. Исследование содержания гемоглобина в крови у женщин в условиях Южного Приаралья // Вестник Каракалпакского отделения Академии наук Республики Узбекистан. 2009. № 1, С. 37-39][Негашева М. А. Основы антропометрии: учебное пособие для обучающихся в образовательных организациях высшего образования по направлению 03.06.01 «Биология» / МГУ им. М. В. Ломоносова, Биологический факультет. М.: Экон-Информ, 2017. 216 с][Реймов Р. Р., Константинова Л. Г. Экологическая характеристика Приаралья и пространственная дифференциация его территории как зоны экологического бедствия // Вестник Каракалпакского отделения Академии наук Республики Узбекистан. 1992. № 2, С. 3-8][Ashley-Martin J., Dodds L., Arbuckle T. E., Morisset A. S., Fisher M., Bouchard M. F., Shapiro G. D., Ettinger A. S., Monnier P., Dallaire R., Taback S., Fraser W. Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain. Int J Environ Res Public Health. 2016 Jan 20;13 (1). pii: E146. DOI: 10.3390/ ijerph13010146][Bapayeva G., Issayeva R., Zhumadilova A., Nurkasimova R., Kulbayeva S., Tleuzhan R. Organochlorine pesticides and female puberty in South Kazakhstan. Reprod Toxicol. 2016 Oct; 65, pp. 67-75. DOI: 10.1016/j. reprotox.2016.06.017. Epub 2016 Jun 23.][Bogin B., Varela-Silva M. I. Leg length, body proportion, and health: a review with a note on beauty. Int J Environ Res Public Health. 2010 Mar; 7 (3), pp. 1047-75. DOI: 10.3390/ ijerph7031047. Epub 2010 Mar 11.][Burns J. S., Williams P. L., Lee M. M., Revich B., Sergeyev O., Hauser R., Korrick S. A. Peripubertal blood lead levels and growth among Russian boys. Environ Int. 2017 Sep; 106, pp. 53-59. DOI: 10.1016/j.envint.2017.05.023. Epub 2017 Jun.][Burns J. S., Williams P. L., Korrick S. A., Hauser R., Sergeyev O., Revich B., Lam T., Lee M. M. Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function. Am J Epidemiol. 2014 Nov 1; 180 (9), pp. 909-19. DOI: 10.1093/aje/kwu212. Epub 2014 Sep 25.][Carrizo D., Grimalt J. O., Ribas-Fito N., Sunyer J., Torrent M.Physical-chemical and maternal determinants of the accumulation of organochlorine compounds in four-year-old children. Environ Sci Technol. 2006 Mar 1;.40.(5), pp. 1420-6. DOI: 10.1021/es0518427][Crighton E. J., Elliott S. J., Upshur R., van der Meer J., Small I. The Aral Sea disaster and self-rated health. Health Place. 2003 Jun; 9 (2), pp. 73-82. DOI: 10.1016/ s1353-8292(02)00017-5][Eskenazi B., Harley K., Bradman A., Weltzien E., Jewell N. P., Barr D. B., Furlong C. E., Holland N. T. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect. 2004 Jul; 112 (10), pp. 1116-24. DOI: 10.1289/ehp.6789][Gore A. C., Chappell V. A., Fenton S. E., Flaws J. A., Nadal A., Prins G. S., Toppari J., Zoeller R. T. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015 Dec; 36 (6), pp. E1-E150. DOI: 10.1210/er.2015-1010. Epub 2015 Nov 6.][Hamilton J. D., O’Flaherty E. J. Influence of lead on mineralization during bone growth. Fundam Appl Toxicol. 1995 Jul; 26 (2), pp. 265-71. DOI: 10.1006/faat.1995.1097][Havelock J. C., Auchus R. J., Rainey W. E. The rise in adrenal androgen biosynthesis: adrenarche. Semin Reprod Med. 2004 Nov; 22 (4), pp. 337-47. DOI: 10.1055/s-2004-861550][Jensen S., Mazhitova Z., Zetterstrom R. Environmental pollution and child health in the Aral Sea region in Kazakhstan. Sci Total Environ. 1997 Nov 5; 206 (2-3), pp. 187-93.][Johnston F. E. Somatic growth of the infant and preschool child. In: Falkner А. (ed.), Tanner J. M. (ed.) Human growth. Vol. 2: Postnatal Growth. “Plenum Press”. New York, London, 1978, pp. 91-1 17 (634).][Janmohamed A., Karakochuk C. D., McLean J., Green T. J. Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration among Rural Cambodian Women in the First Trimester of Pregnancy. Am J Trop Med Hyg. 2016 Nov 2; 95 (5), pp, 1211-1215. Epub 2016 Aug 22. DOI: 10.4269/ ajtmh.16-0278][Lampl M., Kuzawa C. W, Jeanty P. Prenatal smoke exposure alters growth in limb proportions and head shape in the midgestation human fetus. Am J Hum Biol. 2003 Jul-Aug; 15 (4), pp. 533-46. DOI: 10.1002/ajhb.10140][Mark M., Rijli F. M., Chambon P. Homeobox genes in embryogenesis and pathogenesis. Pediatr Res. 1997 Oct; 42 (4), pp. 421-9. DOI: 10.1203/00006450-199710000-00001][Marshall V. A. Puberty. In: Falkner А. (ed.), Tanner J. M. (ed.) Human growth. Vol. 2: Postnatal Growth. “Plenum Press”. New York, London, 1978, pp. 141-182 (634)][Merrill R. D., Burke R. M., Northrop-Clewes C. A., Rayco-Solon P, Flores-Ayala R., Namaste S. M., Serdula M. K., Suchdev P S. Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017 Jul; 106 (Suppl 1), pp. 348S-358S. DOI: 10.3945/ ajcn.1 16.142315. Epub 2017 Jun 14][Mink P. J., Kimmel C. A., Li A. A. Potential effects of chlorpyrifos on fetal growth outcomes: implications for risk assessment. J Toxicol Environ Health B Crit Rev. 2012; 15 (4), pp. 281-316. DOI: 10.1080/10937404.2012.672150][Muntean N., Jermini M., Small I., Falzon D., Furst P, Migliorati G., Scortichini G., Forti A. F., Anklam E., von Holst C., Niyazmatov B., Bahkridinov S., Aertgeerts R., Bertollini R., Tirado C., Kolb A. Assessment of dietary exposure to some persistent organic pollutants in the Republic of Karakalpakstan of Uzbekistan. Environ Health Perspect. 2003 Aug; 111 (10), pp. 1306-1 1. DOI: 10.1289/ehp.5907][Ritter R., Scheringer M., MacLeod M., Moeckel C., Jones K. C., Hungerbuhler K. Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom. Environ Health Perspect. 2011 Feb; 119 (2), pp. 225-31. DOI: 10.1289/ehp.1002211. Epub 2010 Oct 7.][Roy J. R., Chakraborty S., Chakraborty T. R. Estrogenlike endocrine disrupting chemicals affecting puberty in humans--a review. Med Sci Monit. 2009 Jun; 15 (6), pp. RA137-45.][Rzymski P, Klimaszyk P, Niedzielski P, Marszelewski W, Borowiak D., Nowinski K., Baikenzheyeva A., Kurmanbayev R., Aladin N. Pollution with trace elements and rare-earth metals in the lower course of Syr Darya River and Small Aral Sea, Kazakhstan. Chemosphere. 2019 Nov; 234, pp. 81-88. DOI: 10.1016/j.chemosphere.2019.06.036][Sen A., Heredia N., Senut M. C., Land S., Hollocher K., Lu X., Dereski M. O., Ruden D. M. Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Sci Rep. 2015 Sep 29; 5, pp. 14466. DOI: 10.1038/srep14466][Sergeyev O., Burns J. S., Williams P L., Korrick S. A., Lee M. M., Revich B., Hauser R. The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children’s Study. Rev Environ Health. 2017 Mar 1; 32 (1-2), pp. 83-92. DOI: 10.1515/reveh-2016-0052][Soliman A. T., De Sanctis V, Yassin M., Adel A.Growth and Growth hormone - Insulin Like Growth Factor -I (GH-IGF-I) Axis in Chronic Anemias. Acta Biomed. 2017 Apr 28; 88 (1), pp. 101-111. DOI: 10.23750/abm.v88i1.5744][Song S., Ma X., Pan M., Tong L., Tian Q. Excretion kinetics of three dominant organochlorine compounds in human milk within the first 6 months postpartum. Environ Monit Assess. 2018 Jul 11; 190 (8), pp. 457. DOI: 10.1007/ s10661-018-6850-9][Tinggaard J., Wohlfahrt-Veje C., Husby S., Christiansen L., Skakkebaek N. E., Jensen T. K., Grandjean P, Main K. M., Andersen H. R. Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X-ray absorptiometry (DXA). Andrology. 2016 Jul; 4 (4), pp. 735-44. DOI: 10.1111/ andr.12194. Epub 2016 May 26.][Vandenberg L. N., Colborn T., Hayes T. B., Heindel J. J., Jacobs D. R. Jr, Lee D. H., Shioda T., Soto A. M., vom Saal F. S., Welshons W V, Zoeller R. T., Myers J. P. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012 Jun; 33 (3), pp. 378-455. DOI: 10.1210/er.2011-1050. Epub 2012 Mar 14.][Wohlfahrt-Veje C., Main K. M., Schmidt I. M., Boas M., Jensen T. K., Grandjean P., Skakkeb®k N. E., Andersen H. R. Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study. Environ Health. 2011 Sep 20; 10, p. 79. DOI: 10.1 186/1476-069X-10-79][Zumbado M., Luzardo O. P., Lara P. C., Alvarez-Leon E. E., Losada A., Apolinario R., Serra-Majem L., Boada L. D. Insulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: relationship to level of contamination by DDT-derivative pesticides. Growth Horm IGF Res. 2010 Feb; 20 (1), pp. 63-7. DOI: 10.1016/j. ghir.2009.07.003. Epub 2009 Aug 20.]