Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)Экология человека1728-08692949-1444Eco-Vector63177910.17816/humeco631779REVIEWSОБЗОРЫReview ArticlePersistent organic pollutants in the human body: Russian and Soviet studiesСудьба стойких органических загрязняющих веществ в организме человека (исследования России и СССР)人体内持久性有机污染物的命运（俄罗斯和苏联的研究）https://orcid.org/0000-0002-5791-54938381-4723GumovskayaYulia P.ГумовскаяЮлия ПетровнаGumovskayaYulia P.
Russian Federation

MD, Cand. Sci. (Medicine), Assistant Professor

канд. мед. наук, доцент

nupl@yandex.ruhttps://orcid.org/0000-0002-3746-10842358-3800MironovaEkaterina KМироноваЕкатерина КонстантиновнаMironovaEkaterina K.
Russian Federation

Postgraduate Student

аспирант

mironova_kate@bk.ruhttps://orcid.org/0000-0002-3342-178X9627-6694PolevshchikovAlexander V.ПолевщиковАлександр ВитальевичPolevshchikovAlexander V.
Russian Federation

Dr. Sci. (Biology), Professor

д-р биол. наук, профессор

polevshikov.av@iemspb.ruhttps://orcid.org/0000-0002-2108-44489023-6473DonetsMaksim M.ДонецМаксим МихайловичDonetsMaksim M.
Russian Federation
maksim.donecz@mail.ruhttps://orcid.org/0000-0002-5095-72605047-8410TsygankovVasiliy Yu.ЦыганковВасилий ЮрьевичTsygankovVasiliy Yu.
Russian Federation

Dr. Sci. (Biology), Associate Professor

д-р биол. наук, доцент

tsig_90@mail.ruFar Eastern Federal UniversityДальневосточный федеральный университетFar Eastern Federal UniversityInstitute of Experimental MedicineИнститут экспериментальной медициныInstitute of Experimental MedicinePacific Geographical Institute of the Far Eastern Branch of the Russian Academy of SciencesТихоокеанский институт географии Дальневосточного отделения Российской академии наукPacific Geographical Institute of the Far Eastern Branch of the Russian Academy of Sciences13012025251220243164294462005202426112024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-ВекторCopyright ©; 2024,2024Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0https://hum-ecol.ru/1728-0869/article/view/631779

This review presents data on the prevalence and use of persistent organic pollutants in Russia. It highlights current biomonitoring studies on their accumulation in human organs and tissues. The article also examines findings from Russian and Soviet studies on the effects of xenobiotics on the human body. Research on the acute toxicity of these substances peaked in the 1960s–1970s, while studies on their chronic effects began to emerge in the 1980s–1990s. Currently, such studies are extremely scarce.

В обзоре приведены данные о распространённости и использовании стойких органических загрязняющих веществ в России. Описаны актуальные биомониторинговые исследования стойких органических загрязнителей в органах и тканях человека. Рассмотрены результаты российских и советских исследований о влиянии ксенобиотиков на человеческий организм. Пик изучения острого воздействия токсикантов на здоровье человека пришёлся на 1960–1970 гг. В 1980–1990 гг. появляются работы, изучающие их хроническое воздействие. В настоящее время подобных работ крайне мало.

本综述探讨了俄罗斯境内持久性有机污染物的分布情况及其应用历史，并总结了关于这些污染物在人体器官和组织中累积的生物监测研究。此外，文章回顾了俄罗斯和苏联关于外源性化合物对人体健康影响的研究成果。在苏联，有关 POPs 急性毒性的研究高峰期出现在20世纪60–70年代，而对其慢性影响的系统性研究始于20世纪80–90年代。然而，近年来此类研究已大幅减少，导致对持久性有机污染物长期暴露风险的认识仍存在诸多空白。

persistent organic pollutantsbiomonitoringhuman healthbody impactUSSRRussiaстойкие органические загрязнителибиомониторингздоровье человекавлияние на организмСССРРоссия持久性有机污染物生物监测人体健康对机体的影响苏联俄罗斯Министерство науки и высшего образования Российской ФедерацииRussian Ministry of Education and ScienceUNEP. Stockholm Convention on Persistent Organic Pollutants; 2020. 96 р.Ushakov AA, Turbinskiy VV, Paschenko IG, Katunina AS. Hygienic assessment of habitat adverse social and sanitary factors in the Altai Krai. Health Risk Analysis. 2015;(4):50–61. doi: 10.21668/health.risk/2015.4.07 EDN: VHWPFTTsygankov VYu, Boyarova MD, Kiku PF, Yarygina MV. Hexachlorocyclohexane (HCH) in human blood in the south of the Russian Far East. Environmental Science and Pollution Research. 2015;22(18):14379–14382. doi: 10.1007/s11356-015-4951-3 EDN: UZYOXDTsygankov VY, Khristoforova NK, Lukyanova ON, et al. Selected organochlorines in human blood and urine in the south of the Russian Far East. Bulletin of Environmental Contamination and Toxicology. 2017;(99):460–464. doi: 10.1007/s00128-017-2152-0 EDN: WUHSCBTsygankov VY, Yarygina MV, Lukyanova ON, et al. Trace concentrations of organochlorine compounds in biological liquids of the Russian far east residents. Ekologiya Cheloveka (Human Ecology). 2019;26(1):15–19. doi: 10.33396/1728-0869-2019-1-15-19 EDN: QRLCUZTsygankov VYu. Organochlorine pesticides in marine ecosystems of the Far Eastern Seas of Russia (2000–2017). Water Research. 2019;161:43–53. doi: 10.1016/j.watres.2019.05.103Rovinsky FYa, Voronova LD, Afanasyev MI, et al. Background monitoring of pollution of terrestrial ecosystems by organochlorine compounds. Leningrad: Gidrometeoizdat; 1990. (In Russ.)Tsydenova OV. Organochlorine compounds in the ecosystems of Lake Baikal and its basin [dissertation abstract]. Barnaul; 2005. 23 p. (In Russ.) EDN: NIGKVBOrder dated April 13, 1999 No. 165 “About Recommendations for the purposes of inventory in the territory of the Russian Federation of production facilities, equipment, materials using or containing PCBs, as well as PCB-containing wastes”. Available from: https://base.garant.ru/2156962 (In Russ.)Order dated February 23, 1999 No 76 “On conducting an inventory of production facilities, equipment, materials using or containing polychlorinated biphenyls (PCBs), as well as PCB-containing wastes on the territory of the Russian Federation”. Available from: https://base.garant.ru/2156961 (In Russ.)Speranskaya O, Tsittser O. Persistent organic pollutants: an overview of the situation in Russia. Moscow; 2004. (In Russ.)Yearbook “The state of pesticide pollution in the natural environment of the Russian Federation in 2016”. Obninsk: FGBU NPO Taifun; 2017. (In Russ.)Semerenko SA. Ecology and plant protection. Oil Crops. 2015;(4):103–137. EDN: VHTFHPChernykh AM. Threats to human health in the use of pesticides (a review). Hygiene and Sanitation. 2003;(5):25–28. EDN: MXPFKILarionov KV. The spread of pesticides in the ecosystem of the Krasnodar Territory and the minimization of their impact on the environment [dissertation]. Krasnodar; 2008. 135 p. (In Russ.) EDN: NQHUNFChernogaeva GM, Gromov SA, Zhdanovskaya EA, et al., editors. Review of the state and pollution of the environment in the Russian Federation for 2018. Moscow; 2019. (In Russ.) EDN: ZUYSGBKorpakova IG, Korotkova LI, Larin AA, et al. Availability of persistent organochlorine pesticides and polychlorbiphenyls in the water area of the licensed site of LLC “NC “Priazovneft” in the Azov Sea. Environmental Protection in Oil and Gas Complex. 2015;(11):48–54. EDN: UNHDXXOn measures to ensure that the Russian Federation fulfills its obligations under the Stockholm Convention on Persistent Organic Pollutants of May 22, 2001. As amended by Resolutions of the Government of the Russian Federation No. 464 dated 05/13/2015, No. 946 dated 09/19/2016, No. 1391 dated 11/20/2018, No. 113 dated 02/11/2019. (In Russ.)Sobol M. Time to act. Moscow; 2004. (In Russ.)Lukyanova ON, Tsygankov VYu, Boyarova MD, Khristoforova NK. Pesticide biotransport by Pacific salmon in the northwestern Pacific Ocean. Doklady Biological Sciences. 2014;456(1):188–190. doi: 10.1134/S0012496614030089 EDN: UGPRJRLukyanova ON, Tsygankov VYu, Boyarova MD, Khristoforova NK. Pacific salmon as a vector in the trasnsfer of persistent organic pollutants in the Ocean. Journal of Ichthyology. 2015;55(3):425–429. doi: 10.1134/S0032945215030078 EDN: VAELIZPavlov AV, editor. Handbook of pesticides (hygiene of use and toxicology). Kyiv: Urojay; 1986. (In Russ.)Saleh MA, Kamel A. Breast milk as a biomarker for monitoring human exposure to environmental pollutants. ACS Symposium Series. 1996;643:114–125.Krauthacker B, Reiner E, Votava-Raić A, et al. Organochlorine pesticides and PCBs in human milk collected from mothers nursing hospitalized children. Chemosphere. 1998;37(1):27–32. doi: 10.1016/S0045-6535(98)00035-6Liderman EM, Zabelin MV. Analysis of ecological conditions of conditionality of the population health in the southern federal district in aspect of the organization of the regional system of medico-social rehabilitation. Healthcare, Education and Security. 2018;(1):7–20. EDN: YRXBQTInelova ZA, Nurzhanova AA, Zhamabalinova RD, et al. Phytocenotic bioindication of pesticide-contaminated soils (Talgar district, Almaty region). Eurasian Journal of Ecology. 2010;(3):29–33. (In Russ.)Rakitskyi VN. Prognostic risk of pesticides’ toxic effects in workers. Russian Journal of Occupational Health and Industrial Ecology. 2015;(10):5–7. EDN: UMUIOFKapysheva UN, Bakhtiyarova ShK, Zhaksymov BI. Effects of long-term pesticidal pollution environmental human health. International Journal of Applied and Basic Research. 2019;(3):56–60. EDN: FIHYJORuder AM, Waters MA, Butler MA, et al. Gliomas and farm pesticide exposure in men: the upper midwest health study. Archives of Environmental Health: An International Journal. 2004;59(12):650–657. doi: 10.1080/00039890409602949Ivanov AV, Vasilyev VV. Human health status in the areas with intensive use of peptides. Hygiene and Sanitation. 2005;(2): 24–27. EDN: OJNQGVRuzybakeev RM. Immunodeficiency states in chronic pesticide intoxication and the problem of their correction: clinical and experimental study [dissertation abstract]. Moscow; 1987. 32 р. (In Russ.)Onikienko F.A. The state of some aspects of carbohydrate metabolism and oxidative processes when exposed to the body of certain organochlorine insecticides [dissertation abstract]. Kyiv; 1966. 18 р. (In Russ.)Gravel’ IV. Assessment of the transition of DDT and its metabolites to liquid extracts and tinctures from medicinal plant raw materials. Traditional Medicine. 2005;(1):28–31. (In Russ.) EDN: HSPHZRZhurba OM, Taranenko NA. Social-hygienic aspects of determining the residual amounts of chloroganic pesticides in food products. Bulletin of the East Siberian Scientific Center SB RAMS. 2007;(1):56–58. EDN: KVMIADZacharenkov VV, Kislitsyna VV. Prioritization of environmental measures based on risk assessment for the health of the population of an industrial city. Advances in Current Natural Sciences. 2014;(2):12–15. EDN: PZXPLIBarr DB, Barr JR, Driskell WJ, et al. Strategies for biological monitoring of exposure for contemporary-use pesticides. Toxicol Ind Health. 1999;15(1-2):168–179. doi: 10.1191/074823399678846556Rovinskii FYa, Voronova LD, Afanas’ev MI, et al. Background monitoring of pollution of terrestrial ecosystems by organochlorine compounds. Leningrad: Hydrometeoizdat; 1990. (In Russ.)Galiulin RV, Galiulina RA. Ecological and geochemical assessment of the “imprints” of persistent organochlorine pesticides in the soil-surface water system. Agrohimia. 2008;(1):52–58. (In Russ.) EDN: IBYXQRBurns JS, Williams PL, Korrick SA, et al. Association between chlorinated pesticides in the serum of prepubertal russian boys and longitudinal biomarkers of metabolic function. American Journal of Epidemiology. 2014;180(9):909–919. doi: 10.1093/aje/kwu212Shumeyko AYa. Ecological assessment of the interaction of pesticides and radiation in agroecosystems of the Bryansk region [dissertation abstract]. Bryansk; 2004. 22 р. (In Russ.) EDN: NHRFBLLotkov VS. Clinical and pathogenetic features of the chronic effects of chlorinated hydrocarbons on the respiratory organs and other body systems (experimental clinical study) [dissertation abstract]. Samara; 2000. 38 р. (In Russ.)Fedorov LA, Yablokov AV. Pesticides are a toxic blow to the biosphere and humans. Moscow: Nauka; 1999. (In Russ.)Boikulov MCh. Comparative characteristics of the aorta of rats in normal and under the influence of pesticides. Morfologiya. 2004;(4):22. (In Russ.)Shitskova AP, Nikolaeva NI, Gadalina ID. Hygienic assessment of the cardiotoxic effect of certain pesticides. Hygiene and Sanitation. 1986;(6):6–9. (In Russ.)Gadalina ID. Some methodological approaches to assessing the cardiotoxic effect of pesticides, taking into account the age factor. Hygiene and Sanitation. 1990;(7):77–78. (In Russ.)Akhmedov BKh, Saliev KK. Peripheral blood parameters in rats with chronic pesticide intoxication. Medical Journal of Uzbekistan. 2000;(3):89–90. (In Russ.)Azovskova TA, Vakurova NV, Lavrentieva NE. Occupational intoxication with pesticides. Samara: SamLyuksPrint; 2014. (In Russ.) EDN: TZJLJBOvchinnikova EL, Rezanova NV, Brusentsova AV. Monitoring of food quality and safety as an integral part of social and hygienic monitoring. Sibir’-Vostok. 2003;(10):31–36. (In Russ.)Khaitov RM, Pinegin BV, Istamov XI. Ecological immunology. Moscow: VNIRO; 1995. (In Russ.)Israilova M. Clinical and immunological features of the course and treatment of prolonged pneumonia in patients living in the pesticide application area [dissertation abstract]. Moscow; 1992. 19 р. (In Russ.)Omarova ZM. Effect of pesticides on children’s health. Russian Bulletin of Perinatology and Pediatrics. 2010;55(1):59–64. EDN: LOQNLKOdland JØ, Donaldson S, Dudarev A, Carlsen A. AMAP assessment 2015: human health in the Arctic. Int J Circumpolar Health. 2016;75:33949. doi: 10.3402/ijch.v75.33949Latypova RI. Functional state of kidneys in people working with a complex of organochlorine and phosphorous pesticides. Medical Journal of Uzbekistan. 1971;(11):19–23. (In Russ.)Allazov S. Acute infectious and inflammatory kidney diseases under the influence of pesticides (clinical and experimental study) [dissertation abstract]. Moscow; 1992. 28 р. (In Russ.)Sitdikova ME, Allazov SA, Sayapova DR. The effect of organochlorine compounds on some urological diseases. Kazan Medical Journal. 2010;91(3):372–374. EDN: MUEJYFRasulov MT, Shakhnazarov MA, Shakhnazarov AM, Magomedgadzhiev BG. Morphological and histoenzymatic characteristics of kidneys under chronic exposure to pesticides hexachlorocyclohexane, chlorophos and copper sulfate. In: Problems of environmental medicine. Materials of the VII scientific and practical conference in memory of Professor S.A. Abusuev. Makhachkala; 2017;242–245. (In Russ.) EDN: XUPCCLNikitin AI. Harmful environmental factors and the human reproductive system (responsibility to future generations). St. Petersburg: ELBI-SPb; 2008. (In Russ.)Nikitin AI. Hormone-like pollutants of the biosphere and their effect on human reproductive function. Biosfera. 2009;1(2):218–229. EDN: QZOGHVMoshanskii VF, Kagan SA, Tektinskii OL, et al. Differential diagnosis of 2 forms of necrospermia. Urol Nefrol (Mosk). 1987;52(5):57–59.Toichuev RM, Mirzakulov DS, Payzildaev TR. The prevalence of male infertility in residents living in conditions of the pollution of the environment by organochlorine pesticides. Hygiene and Sanitation. 2015;94(6):99–101. EDN: UXZQYVRevich BA, Sergeyev OV, Shelepchikov AA. Innovative environmental and epidemiologic technologies of assessment of dioxins impacts on childrens health. Ekologiya cheloveka (Human Ecology). 2012;19(8):42–49. doi: 10.17816/humeco17455 EDN: PAIJYXDudarev AA. Persistent polychlorinated hydrocarbons and heavy metals in arctic biosphere: the main regularities of exposure and reproductive health of indigenous people. Biosfera. 2009;1(2):186–202. EDN: QZOGGRTer-Avanesov GV. Problems of men’s reproductive health. Moscow: Telsi; 2004. (In Russ.)Mirzakulov DS, Eshbaev AA, Mirzokulov SS, Kalmatov RK. Features of influence of organochlorine compounds and their metabolites on the state of fertility men living in the osh region of Kyrgyzstan. Modern Problems of Science and Education. 2016;(3):66. EDN: WXJAFPKorot’ko GF. The salivadiagnostics — renaissance of non-invasive technologies. Kuban Scientific Medical Bulletin. 2006;(9):145–149. EDN: HVFWFTZhumatov U. The state of the organs of the oral cavity when exposed to organochlorine and phosphorous pesticides [dissertation abstract]. Tashkent; 1982. 19 р. (In Russ.)Abdullaev RB, Duschanov ShB, Matkarimova DS, et al. The Aral crisis: problems of ecological culture and health. Urgench; 2012. (In Russ.)Adamovich VL, Samoylenko VM. Ecological tactics of using pesticides in agriculture and ways to prevent harmful effects. Bryansk; 1986. (In Russ.)Paizova ZM, Toychuev RM. The influence of environmental pollution with organochlorine pesticides on the development of breast cancer in women, depending on the number of births, in the conditions of southern Kyrgyzstan. The Journal of Scientific Articles Health and Education Millennium. 2012;14(1):160. (In Russ.) EDN: QAJXUBGichev YuP. Environment Pollution and Ecology-related Human Pathology. Ecology. A series of analytical reviews of world literature. 2003;(68):1–138. EDN: HKZNPTMustafakulova NI, Melikova TI, Mustafakulova NS. Risk factors and clinical features of leukemia sin the Republic of Tajikistan. Avicenna Bulletin. 2015;(1):67–71. EDN: UHLUWTSolenova LG. Cancer risk factors in children and approaches to prevention of their effects. Pediatriya. Zhurnal im G.N. Speranskogo. 2011;90(4):120–126. (In Russ.) EDN: OGHFXJAylamazyan EK, Belyaeva TV, Vinogradova EG. The influence of environmental conditions on women’s reproductive health. A new perspective on the problem. Bulletin of the Russian Association of Obstetricians and Gynecologists. 1996;(2):13–16. (In Russ.)Dudarev AA, Chupakhin VS. Influence of exposure to persistent toxic substances (PTS) on pregnancy outcomes, gender ratio and menstrual status in indigenous females of Chukotka. Hygiene and Sanitation. 2014;93(1):36–40. EDN: RYDZAZToichuev RM. The effect of organochlorine pesticide content in placenta on the course of pregnancy and childbirth. Hygiene and Sanitation. 2015;94(6):106–108. EDN: UXZRAJVerzhanskiy PS. The effect of combined pesticides (fentiuram, chromicin, etc.) on reproductive function and prevention of complications in women working at a chemical enterprise [dissertation abstract]. Kharkov; 1979. 22 р. (In Russ.)Yudaev AI. Polychlorinated biphenyls and dioxins — superecotoxicants of the 21st century. Energiia: Ekonomika, Tekhnika, Ekologiia. 2010;(1):60–65. (In Russ.) EDN: LSOYBVDemchenko VF. Hygienic aspects of biomonitoring of organochlorine pesticides [dissertation]. Kyiv; 1989. 332 р. (In Russ.)Komarova LI. Carriage of DDT and some aspects of its effect on the body [dissertation abstract]. Kyiv; 1969. 12 р. (In Russ.)Khamitova RYa, Mirsaitova GT. The population morbidity in conditions of lasting moderate application of pesticides. Health Care of the Russian Federation. 2014;58(1):38–42. EDN: RVLZZPDarbishev EP, Eshiev AM. he influence of organochlorine pesticides on the birth rate of children with congenital pathology in the Osh region. In: Actual problems and achievements in medicine. Collection of scientific papers based on the results of the international scientific and practical conference. Samara; 2017. Р. 96–99. (In Russ.) EDN: YNQHEZKhamidov MH. Reproductive function, outcome of pregnancy and childbirth for the fetus and newborn in women engaged in the cultivation and cultivation of cotton [dissertation abstract]. Leningrad; 1986. 46 р. (In Russ.)del Puerto C, Diaz Fernandez AM, de Armas Jimenez M, et al. The levels of DDT and its metabolites in the human biological medium. Gig Sanit. 1990;(10):73–75.Zastenskaya IA, Kochubinsky VV. Potential role of epidemiological researches and biological monitoring in hygienic rate setting. Actual Problems of Transport Medicine. 2010;(2):90–94. EDN: PZEYNXGoncharuk EI, Sidorenko GI, Golubchikov MV, Prokopovich AS. Using the mother-fetus-newborn system to study the combined effects of pesticides and other chemicals. Hygiene and Sanitation. 1990;(6):4–7. (In Russ.)Tadevosyan NS, Tadevosyan AE, Janjapanyan AN, et al. Issues of accumulation and detection of certain persistent organic pollutants in rural residents of Armenia. Vestnik KazNMU. 2012;(3):212–221. (In Russ.)Ginsberg G, Hattis D, Sonawane B. Incorporating pharmacokinetic differences between children and adults in assessing children’s risks to environmental toxicants. Toxicol Appl Pharmacol. 2004;198(2):164–183. doi: 10.1016/j.taap.2003.10.010Mamontova YeA, Tarasova YeN, Kuzmin MI, et al. The levels of stable organic pollutants in the breast milk of women living in the Urkutsk Region. Hygiene and Sanitation. 2010;(1):35–38. EDN: MBUWKJAlharbi OM, Basheer AA, Khattab RA, Ali I. Health and environmental effects of persistent organic pollutants. Journal of Molecular Liquids. 2018;263:442–453. doi: 10.1016/j.molliq.2018.05.029Tadevosyan NS, Muradyan SA, Tadevosyan AE, et al. Monitoring of environmental pollution in armenia and certain issues on reproductive health and cytogenetic status of organism. Hygiene and Sanitation. 2012;91(5):48–51. EDN: PUHIUJAMAP Assessment 2002: Persistent organic pollutants in the Arctic. Norway, Oslo: Arctic Monitoring Assessment Program; 2004. 310 p.Mamontova EA, Tarasova EN., Mamontov AA. Ecological and hygienic assessment of the consequences of persistent organic compounds pollution of the industrial town (by the example of Usol’e-Sibirskoe): II. Food, human tissues, health risk assessment. Ecological Chemistry. 2017;26(1):41–52. EDN: XWRXUTZastenskaya IА. Organochlorine pesticides: biological monitoring and environmental monitoring in evaluation of newborn health impact. Health and Environment. 2009;(14):540–547. EDN: ZCDVHLYufit S, Leeuwen R, Malisch R, Samsonov DP. Contamination of human milk with PCDDS, PCDFS and PCBS in two Russian cities. Organohalogen Compounds. 2002;56:333–336.Tsygankov VY, Gumovskaya YP, Gumovskiy AN, et al. Bioaccumulation of POPs in human breast milk from south of the Russian Far East and exposure risk to breastfed infants. Environ Sci Pollut Res. 2020;27:5951–5957. doi: 10.1007/s11356-019-07394-y.Dudarev AA, Dushkina, EV, Sladkova YN, et al. Exposure Levels of Persistent Organic Pollutants (POPs) among Population of the Pechenga District in the Murmansk Region. Toxicological Review. 2016;(3):2–9. doi: 10.36946/0869-7922-2016-3-2-9Tsydenova, OV, Sudaryanto A, Kajiwara N, et al. Organohalogen Compounds in Human Breast Milk from Republic of Buryatia, Russia. Environmental Pollution. 2007;146(1):225–232. doi: 10.1016/j.envpol.2006.04.036Sergeyev O, Shelepchikov A, Denisova T, et al. POPs in human milk in Chapaevsk, Russia, five years following cessation of chemical manufacturing and decade of remediation program, pilot study. Organohalogen Compounds. 2008;70:1946–1949.Amirova ZK, Shahtamirov IY. PCDD / Fs and PCBs-WHO in plasma and breast milk of residents of the Chechen Republic. South of Russia: Ecology, Development. 2012;7(2):125–129. EDN: PLRCDVMoskovchuk OB, Moskovchuk KM, Demchenko VF, Evstafieva HV. Correlations of indicators of the immune status of maternity hospitals with the content of organochlorine pesticides in the blood. Tavricheskiy Mediko-Biologicheskiy Vestnik. 2012;15(3-2):176–178. (In Russ.) EDN: TEGGGDDudarev AA, Chupakhin VS, Ivanova ZS, Lebedev GB. Peculiarities of exposure to polychlorinated biphenyls (PCBs) in the indigenous population of the coastal and mainland Chukotka. Hygiene and Sanitation. 2012;91(4):22–28. EDN: PTUMUXRevich BA, Sergeev OV, Hanser R. Dioxins, furans and PCB in blood of tecnagers in the town of Chapayevsk first outcome of a perspective epidemiological study. Toxicol Rev. 2006;(5):2–8.Vaskovskaya LF. Chemical and biological characteristics of DDT accumulation and distribution in the human body [dissertation]. Kyiv; 1971. 192 р. (In Russ.)Kuzminskaya UA. Biochemical characteristics of subcellular structures of the liver under the influence of pesticides (on the mechanism of action of organochlorine and carbamate pesticides) [dissertation abstract]. Kyiv; 1975. 42 р. (In Russ.)Azizova OM. Morphological changes in the brain during chronic pesticide intoxication [dissertation abstract]. Moscow; 1981. 28 р. (In Russ.)Le Phuoc Cuong, Evgen’ev MI, Gumerov FM, Evgen’eva I, Umarova NN. Ecomonitoring of pesticides in the hair of Vietnamese living in Da Nang (Vietnam) and Kazan. Bulletin of the Technological University. 2011;(18):31–37. (In Russ.) EDN: OJKBHNDomingo JL. Concentrations of environmental organic contaminants in meat and meat products and human dietary exposure: A review. Food Chem Toxicol. 2017;107(Pt A):20–26. doi: 10.1016/j.fct.2017.06.032Mironova EK, Donets MM, Gumovskiy AN, et al. Organochlorine pollutants in human breast milk from north of the Far Eastern Region of Russia. Bulletin of Environmental Contamination and Toxicology. 2023;110:95. doi: 10.1007/s00128-023-03732-6Mironova EK, Donets MM, Gumovskiy AN, et al. Persistent organic toxicants in breast milk of women in the south and north of the Russian Far East and risk assessment for infant health. Toxicological Review. 2023;31(2):99–108. doi: 10.47470/0869-7922-2023-31-2-99-108 EDN: DRHMXW