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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">634225</article-id><article-id pub-id-type="doi">10.17816/humeco634225</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDY ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Comprehensive assessment of the effects of omega-3 polyunsaturated fatty acids on the functional status of northern residents during a critical season</article-title><trans-title-group xml:lang="ru"><trans-title>Комплексная оценка влияния полиненасыщенных жирных кислот омега-3 на функциональное состояние жителей-северян в критический период года</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>在关键季节期间，ω-3 多不脂肪酸对北方居民功能状态的综合影响评估</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4511-6782</contrib-id><contrib-id contrib-id-type="spin">9402-0363</contrib-id><name-alternatives><name xml:lang="en"><surname>Averyanova</surname><given-names>Inessa V.</given-names></name><name xml:lang="ru"><surname>Аверьянова</surname><given-names>Инесса Владиславовна</given-names></name><name xml:lang="zh"><surname>Averyanova</surname><given-names>Inessa V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Biology), Professor FEB RAS</p></bio><bio xml:lang="ru"><p>д-р биол. наук, профессор ДВО РАН</p></bio><email>Inessa1382@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5718-5398</contrib-id><contrib-id contrib-id-type="spin">9504-6020</contrib-id><name-alternatives><name xml:lang="en"><surname>Alyoshina</surname><given-names>Olga O.</given-names></name><name xml:lang="ru"><surname>Алёшина</surname><given-names>Ольга Олеговна</given-names></name><name xml:lang="zh"><surname>Alyoshina</surname><given-names>Olga O.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>oalesina597@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3251-5159</contrib-id><contrib-id contrib-id-type="spin">9123-7361</contrib-id><name-alternatives><name xml:lang="en"><surname>Bezmenova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Безменова</surname><given-names>Ирина Николаевна</given-names></name><name xml:lang="zh"><surname>Bezmenova</surname><given-names>Irina N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology)</p></bio><bio xml:lang="ru"><p>канд. биол. наук</p></bio><email>lependina_bel@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4761-5144</contrib-id><contrib-id contrib-id-type="spin">5475-4644</contrib-id><name-alternatives><name xml:lang="en"><surname>Vdovenko</surname><given-names>Sergei I.</given-names></name><name xml:lang="ru"><surname>Вдовенко</surname><given-names>Сергей Игоревич</given-names></name><name xml:lang="zh"><surname>Vdovenko</surname><given-names>Sergei I.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology)</p></bio><bio xml:lang="ru"><p>канд. биол. наук</p></bio><email>vdovenko.sergei@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Scientific Research Center «Arktika» Far Eastern Branch of the Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский центр «Арктика» Дальневосточного отделения Российской академии наук</institution></aff><aff><institution xml:lang="zh">Scientific Research Center «Arktika» Far Eastern Branch of the Russian Academy of Sciences</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-01-23" publication-format="electronic"><day>23</day><month>01</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2024</year></pub-date><volume>31</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>468</fpage><lpage>483</lpage><history><date date-type="received" iso-8601-date="2024-07-11"><day>11</day><month>07</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-12-20"><day>20</day><month>12</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/634225">https://hum-ecol.ru/1728-0869/article/view/634225</self-uri><abstract xml:lang="en"><p><bold>AIM:</bold> To examine the dynamics of morphophysiological and biochemical indicators, stress levels, and the intake of different classes of fatty acids in the human body, identifying essential fatty acid deficiencies before omega-3 polyunsaturated fatty acid (PUFA) supplementation.</p> <p><bold>MATERIALS AND METHODS:</bold> A comprehensive morphophysiological and biochemical study was conducted, analyzing 35 parameters before and after 1.5 months of omega-3 PUFA supplementation.</p> <p><bold>RESULTS:</bold> At baseline, the men in both the experimental and control groups demonstrated similar profiles across all analyzed parameters. After 1.5 months of omega-3 PUFA supplementation (Stage 2), the experimental group exhibited optimization-driven adjustments in several physiological systems. These changes included improvements in cardiovascular function, which facilitated a more optimal metabolic profile, normalization of carbohydrate-lipid metabolism, a significant reduction in the stress hormone cortisol, and a concurrent decrease in overall systemic inflammation, as evidenced by a reduction in the tension matrix of functional reserves. In contrast, the control group, which did not receive docosahexaenoic acid and eicosapentaenoic acid supplementation, did not experience similar adaptations. Instead, maladaptive responses in carbohydrate metabolism, capillary blood flow, and cardiovascular function were observed, which were likely exacerbated by the critical seasonal transition, as ambient temperatures fluctuated around freezing.</p> <p><bold>CONCLUSION:</bold> The findings of this study support the recommendation of omega-3 PUFA supplementation for northern residents as a mitigating factor against the adverse effects of seasonal climatic fluctuations.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold>. Изучение динамики морфофизиологических показателей, биохимического профиля, уровня стресса, а также уровня поступления жирных кислот различных классов в организм человека и выявления дефицита эссенциальных жирных кислот до введения в рацион питания биологически активной добавки с полиненасыщенными жирными кислотами омега-3.</p> <p><bold>Материалы</bold><bold> </bold><bold>и</bold><bold> </bold><bold>методы</bold>. Проведено комплексное морфофизиологическое и биохимическое исследование, включающее в себя анализ 35 показателей, до обогащения рациона питания и после 1,5 мес. приёма биологически активной добавки с полиненасыщенными жирными кислотами омега-3.</p> <p><bold>Результаты</bold>. Показано, что мужчины (опытная и контрольная группы), включённые в анализ, имели сходные показатели по всем анализируемым профилям на момент начала исследования. После 1,5-месячного приёма дополнительной дозы полиненасыщенных жирных кислот семейства омега-3 (2-й этап) в опытной группе наблюдали оптимизационные перестройки по ряду анализируемых систем, что проявлялось в улучшении функционального состояния сердечно-сосудистой системы, в свою очередь обеспечивающего оптимальный метаболический портрет организма, в нормализации углеводно-липидного обмена, в значительном уменьшении концентрации гормона стресса кортизола и одновременном снижении общего воспалительного фона организма, что наглядно представлено в уменьшении площади матрицы напряжения функциональных резервов. Аналогичных перестроек у мужчин группы сравнения, не принимавших добавок с докозагексаеновой и эйкозапентаеновой кислотами, не было; напротив, в данной группе отмечены дизадаптационные проявления углеводного обмена, капиллярного кровотока, состояния сердечной-сосудистой системы, что, по-нашему мнению, обусловлено периодом проведения исследований в самое критическое время года за счёт перехода температурной кривой через ноль.</p> <p><bold>Заключение</bold>. Проведённое исследование может являться основанием для рекомендации приёма биологических активных добавок с полиненасыщенными жирными кислотами омега-3 жителям-северянам как определённого нивелирующего фактора неблагоприятного воздействия сезонных природно-климатических изменений.</p></trans-abstract><trans-abstract xml:lang="zh"><p>研究目的。研究北方居民的形态生理学和生化指标、压力水平以及不同类别脂肪酸的摄入情况，并在补充ω-3 多不饱和脂肪酸前后评估必需脂肪酸缺乏情况的影响。</p> <p>材料与方法。本研究进行了一项综合的形态生理学与生化分析，涵盖35项指标，并比较补充ω-3多不饱和脂肪酸前后（1.5个月）的生理和代谢变化。</p> <p>结果。基线测量：实验组与对照组的受试男性在所有分析参数上表现出相似的特征。补充ω-3 多不饱和脂肪酸1.5 个月后（第二阶段）实验组的多个生理系统出现了优化调整，主要表现为：心血管功能改善，促进更优化的代谢模式；碳水化合物-脂质代谢的正常化；压力激素皮质醇水平显著下降；全身炎症水平同步降低，这一趋势通过功能储备张力矩阵减少得到量化体现。对照组（未摄入二十二碳六烯酸和二十碳五烯酸）：未观察到类似的适应性变化。相反，该组表现出碳水化合物代谢失调、毛细血管血流异常及心血管系统功能失衡，可能与研究期间的气温波动，特别是关键季节温度接近零度的变化相关。</p> <p>结论。研究结果表明，补充ω-3 PUFA可在北方居民中发挥保护作用，有助于缓解季节性气候波动的不利影响，优化心血管健康和代谢功能。</p></trans-abstract><kwd-group xml:lang="en"><kwd>functional reserves</kwd><kwd>northern residents</kwd><kwd>omega-3 polyunsaturated fatty acids</kwd><kwd>optimization role</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>функциональные резервы</kwd><kwd>жители-северяне</kwd><kwd>полиненасыщенные жирные кислоты омега-3</kwd><kwd>оптимизационная роль</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>功能储备</kwd><kwd>北方居民</kwd><kwd>ω-3 多不饱和脂肪酸</kwd><kwd>优化作用</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Министерство науки и высшего образования Российской Федерации</institution></institution-wrap><institution-wrap><institution xml:lang="en">Ministry of Science and Higher Education of the Russian Federation</institution></institution-wrap><institution-wrap><institution xml:lang="zh">Ministry of Science and Higher Education of the Russian Federation</institution></institution-wrap></funding-source><award-id>0225-2021-0001</award-id></award-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">ООО «ОМЕГА-СИ»</institution></institution-wrap><institution-wrap><institution xml:lang="en">LLC "OMEGA-SI"</institution></institution-wrap><institution-wrap><institution xml:lang="zh">LLC "OMEGA-SI"</institution></institution-wrap></funding-source></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Stark KD, Van Elswyk ME, Higgins MR, et al. 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