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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">643517</article-id><article-id pub-id-type="doi">10.17816/humeco643517</article-id><article-id pub-id-type="edn">TRPOGP</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDY ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Prevalence of Anxiety and Depression Symptoms and Their Association with Sleep Quality in Patients with Hypertension</article-title><trans-title-group xml:lang="ru"><trans-title>Распространённость симптомов тревоги и депрессии, их взаимосвязь с качеством сна у пациентов с артериальной гипертензией</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>高血压患者中焦虑与抑郁症状的流行情况及其与睡眠质量的关系</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4578-7893</contrib-id><contrib-id contrib-id-type="spin">4346-6785</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazachenko</surname><given-names>Alexander A.</given-names></name><name xml:lang="ru"><surname>Казаченко</surname><given-names>Александр Александрович</given-names></name><name xml:lang="zh"><surname>Kazachenko</surname><given-names>Alexander A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><email>kazachenko.alex@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2888-9625</contrib-id><contrib-id contrib-id-type="spin">7787-1364</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuchmin</surname><given-names>Alexey N.</given-names></name><name xml:lang="ru"><surname>Кучмин</surname><given-names>Алексей Николаевич</given-names></name><name xml:lang="zh"><surname>Kuchmin</surname><given-names>Alexey N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>kuchmin63@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7820-0481</contrib-id><contrib-id contrib-id-type="spin">7306-8096</contrib-id><name-alternatives><name xml:lang="en"><surname>Golova</surname><given-names>Elena P.</given-names></name><name xml:lang="ru"><surname>Галова</surname><given-names>Елена Петровна</given-names></name><name xml:lang="zh"><surname>Golova</surname><given-names>Elena P.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>galova.elena@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3349-1813</contrib-id><contrib-id contrib-id-type="spin">4059-6128</contrib-id><name-alternatives><name xml:lang="en"><surname>Tanich</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Танич</surname><given-names>Анна Викторовна</given-names></name><name xml:lang="zh"><surname>Tanich</surname><given-names>Anna V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>anya-tanich@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5075-9515</contrib-id><contrib-id contrib-id-type="spin">8139-5706</contrib-id><name-alternatives><name xml:lang="en"><surname>Borisov</surname><given-names>Igor M.</given-names></name><name xml:lang="ru"><surname>Борисов</surname><given-names>Игорь Михайлович</given-names></name><name xml:lang="zh"><surname>Borisov</surname><given-names>Igor M.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>askbo@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1941-7909</contrib-id><contrib-id contrib-id-type="spin">7169-1489</contrib-id><name-alternatives><name xml:lang="en"><surname>Muzikin</surname><given-names>Maxim I.</given-names></name><name xml:lang="ru"><surname>Музыкин</surname><given-names>Максим Игоревич</given-names></name><name xml:lang="zh"><surname>Muzikin</surname><given-names>Maxim I.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Associate Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Associate Professor</p></bio><email>MuzikinM@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5300-5141</contrib-id><contrib-id contrib-id-type="spin">8199-9956</contrib-id><name-alternatives><name xml:lang="en"><surname>Burletova</surname><given-names>Viktoriia A.</given-names></name><name xml:lang="ru"><surname>Бурлетова</surname><given-names>Виктория Алексеевна</given-names></name><name xml:lang="zh"><surname>Burletova</surname><given-names>Viktoriia A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>burletova2000@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0219-1413</contrib-id><contrib-id contrib-id-type="spin">4116-3635</contrib-id><name-alternatives><name xml:lang="en"><surname>Budkovaia</surname><given-names>Marina А.</given-names></name><name xml:lang="ru"><surname>Будковая</surname><given-names>Марина Александровна</given-names></name><name xml:lang="zh"><surname>Budkovaia</surname><given-names>Marina A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>marina-laptijova@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7380-9332</contrib-id><contrib-id contrib-id-type="spin">2475-4340</contrib-id><name-alternatives><name xml:lang="en"><surname>Tytiuk</surname><given-names>Sergei Yu.</given-names></name><name xml:lang="ru"><surname>Тытюк</surname><given-names>Сергей Юрьевич</given-names></name><name xml:lang="zh"><surname>Tytiuk</surname><given-names>Sergei Yu.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>sergei_tytyuk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kirov Military Medical Academy</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия имени С.М. Кирова</institution></aff><aff><institution xml:lang="zh">Kirov Military Medical Academy</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">St.-Petersburg Scientific Research Institute of Ear, Throat, Nose and Speech</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи</institution></aff><aff><institution xml:lang="zh">St.-Petersburg Scientific Research Institute of Ear, Throat, Nose and Speech</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">St. Petersburg Medical and Social Institute</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский медико-социальный институт</institution></aff><aff><institution xml:lang="zh">St. Petersburg Medical and Social Institute</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-07-20" publication-format="electronic"><day>20</day><month>07</month><year>2025</year></pub-date><volume>32</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>135</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2024-12-28"><day>28</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-05-28"><day>28</day><month>05</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/643517">https://hum-ecol.ru/1728-0869/article/view/643517</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> In recent years, substantial evidence has accumulated regarding the negative impact of psychoemotional stress, sleep disorders, and anxiety and depressive disorders on the course of arterial hypertension, as reflected in national guidelines. However, in real-world clinical practice, these aspects are often assessed subjectively and rarely incorporated into the diagnosis; as a result, they frequently receive insufficient attention and are not addressed properly.</p> <p><bold>AIM:</bold><bold> </bold>To assess the prevalence of subclinical and clinically significant anxiety and depression symptoms, as well as their association with sleep quality in patients with hypertension.</p> <p><bold>METHODS:</bold> A single-center, observational, cross-sectional study was conducted. The study included patients admitted for follow-up inpatient examination and treatment at the Department of Propaedeutics of Internal Diseases, S.M. Kirov Military Medical Academy, from 2021 to 2024. During their first days in the hospital, patients completed validated questionnaires assessing psychoemotional status, sleep disorders, and risk of obstructive sleep apnea. The questionnaires included the Hospital Anxiety and Depression Scale, the Insomnia Severity Index, the STOP-BANG Risk Score for Obstructive Sleep Apnea, and the Epworth Sleepiness Scale.</p> <p><bold>RESULTS:</bold><bold> </bold>A total of 348 patients were surveyed, with a mean age of 49.5 ± 20.6 years. The majority of participants were male (83.3%), whereas females comprised 16.7%. Symptoms of subclinical and clinically significant anxiety and depression were reported in 112 patients (32.2%) and 132 patients (37.9%), respectively. A high risk of obstructive sleep apnea was identified in 228 patients (65.5%), whereas 282 patients (81.1%) had moderate sleep disorders. The severity of anxiety and depression moderately correlated with sleep quality (<italic>ρ</italic> = 0.51 and 0.50, respectively; <italic>p</italic> &lt; 0.001) and daytime sleepiness (<italic>r</italic> = 0.43 and 0.57, respectively; <italic>p</italic> &lt; 0.001). Individuals with moderate sleep disorders were 12.88 times more likely to have depression symptoms (95% CI: 4.6–36.4) and 9.62 times more likely to have anxiety symptoms (95% CI: 3.40–27.20); these differences were significant. Moreover, there were significant differences in anxiety and depression severity in patients with exertional angina and a high risk of obstructive sleep apnea, regardless of sex. In female patients, significant differences in anxiety severity were reported (<italic>p</italic> &lt; 0.05).</p> <p><bold>CONCLUSION:<italic> </italic></bold>The findings show that patients with hypertension have a high prevalence of cardiovascular risk factors, including psychoemotional disorders, sleep disorders, and obstructive sleep apnea, emphasizing the importance of comprehensive history taking and using specialized questionnaires in routine clinical practice.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> В последние годы накоплено достаточное количество данных о неблагоприятном влиянии психоэмоционального стресса, нарушений сна, тревожных и депрессивных расстройств на течение артериальной гипертензии, что нашло своё отражение в национальных рекомендациях. Однако в реальной клинической практике oценка этих аспектов зачастую носит субъективный характер, редко включена в общую структуру диагноза, и, как следствие, не получает должного внимания и коррекции.</p> <p><bold>Цель. </bold>Оценить распространённость субклинических и клинически выраженных симптомов тревоги и депрессии, а также их взаимосвязь с качеством сна у пациентов с артериальной гипертензий.</p> <p><bold>Материалы и методы</bold>. Проведено наблюдательное одноцентровое одномоментное исследование. В него включены пациенты, поступившие на плановое стационарное обследование и лечение в клинику пропедевтики внутренних болезней Военно-медицинской академии имени С.М. Кирова в 2021–2024 гг. В течение первых дней госпитализации пациенты заполняли опросники, направленные на оценку психоэмоционального состояния, наличия нарушений сна и риска синдрома обструктивного апноэ сна. В перечень использованных инструментов вошли госпитальная шкала тревоги и депрессии, индекс выраженности бессонницы, опросник для оценки риска обструктивного апноэ и шкала сонливости Эпворта.</p> <p><bold>Результаты. </bold>Опрошены<bold> </bold>348 пациентов, средний возраст составил 49,5±20,6 года. Среди участников исследования преобладали мужчины — 83,3%, доля женщин составила 16,7%. По результатам анализа опросников симптомы субклинической и клинически выраженной тревоги наблюдали у 112 (32,2%) человек, депрессии — у 132 (37,9%). Высокая вероятность синдрома обструктивного апноэ сна выявлена у 228 (65,5%) пациентов, тогда как умеренно выраженные нарушения качества сна — у 282 (81,1%). При анализе взаимосвязи выраженности тревоги и депрессии установлена cредней силы корреляционная связь с качеством сна (<italic>ρ</italic>=0,51 и 0,5 соответственно, <italic>p </italic>&lt;0,001) и выраженностью сонливости (<italic>r</italic>=0,43 и 0,57 соответственно, <italic>p</italic> &lt;0,001). У лиц с умеренно выраженными нарушениями сна шансы выявления симптомов депрессии были выше в 12,88 раза (95% доверительный интервал: 4,6–36,4), симптомов тревожности в 9,62 раза (95% доверительный интервал: 3,40–27,20); различия шансов были статистически значимыми. Кроме того, получены статистически значимые различия в степени выраженности тревоги и депрессии у пациентов со стенокардией напряжения и высокой вероятностью синдрома обструктивного апноэ сна вне зависимости от половой принадлежности, а также для пациентов женского пола по степени выраженности тревожности (<italic>p </italic>&lt;0,05).</p> <p><bold>Заключение. </bold>Данные исследования, продемонстрировав высокую распространённость факторов сердечно-сосудистого риска (психоэмоциональных нарушений, расстройств сна и синдрома обструктивного апноэ сна) у пациентов с артериальной гипертензией, свидетельствуют о важности более детального сбора анамнеза и применения специализированных опросников в клинической практике.</p></trans-abstract><trans-abstract xml:lang="zh"><p>论证。近年来，已有大量研究表明，心理情绪压力、睡眠障碍、焦虑和抑郁等精神心理问题会对高血压的病程产生不良影响，这一认识已被纳入国家临床指南。然而，在实际临床实践中，此类因素的评估往往具有主观性，较少纳入诊断体系，从而缺乏必要的关注与干预。</p> <p>目的。目的： 评估高血压患者中亚临床及临床焦虑、抑郁症状的流行率，并分析其与睡眠质量的相关性。</p> <p>方法：开展了一项单中心横断面观察性研究。研究对象为2021年至2024年期间因计划性住院接受检查与治疗的患者，入院科室为S.M. Kirov Military Medical Academy内科学导论科。住院最初几日内，患者填写了用于评估心理情绪状态、睡眠障碍及阻塞性睡眠呼吸暂停综合征风险的问卷。所用评估工具包括：医院焦虑抑郁量表、失眠严重度指数、阻塞性睡眠呼吸暂停风险评估问卷以及Epworth嗜睡量表。</p> <p>结果。共调查348例患者，平均年龄为49.5±20.6岁。研究参与者中，男性占83.3%，女性占16.7%。问卷结果显示，112例（32.2%）存在亚临床或临床焦虑症状，132例（37.9%）存在抑郁症状。228例（65.5%）存在较高的阻塞性睡眠呼吸暂停风险，282例（81.1%）存在中度睡眠障碍。焦虑和抑郁程度与睡眠质量之间存在中等强度的正相关（ρ = 0.51 和 0.50， p &lt; 0.001），与日间嗜睡程度也呈显著相关（r = 0.43 和 0.57，p &lt; 0.001）。在中度睡眠障碍人群中，抑郁症状的发生风险增加了12.88倍（95% 置信区间：4.6–36.4），焦虑症状增加了9.62倍（95% 置信区间：3.40–27.20），差异具有统计学意义。此外，在合并劳力性心绞痛且具有高阻塞性睡眠呼吸暂停风险的患者中，无论性别，焦虑与抑郁症状的严重程度均呈现统计学显著差异；同时，在女性患者中，焦虑严重度的差异尤为显著（p &lt; 0.05）。</p> <p>结论。本研究结果显示，高血压患者中（心理障碍、睡眠障碍和阻塞性睡眠呼吸暂停综合征）等心血管风险因素的高流行性，凸显了在临床实践中更详细采集相关病史并使用专门评估问卷工具的重要性。</p></trans-abstract><kwd-group xml:lang="en"><kwd>anxiety</kwd><kwd>depression</kwd><kwd>sleep disorders</kwd><kwd>apnea</kwd><kwd>obstructive sleep apnea</kwd><kwd>hypertension</kwd><kwd>prevalence</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тревога</kwd><kwd>депрессия</kwd><kwd>нарушения сна</kwd><kwd>апноэ</kwd><kwd>синдром обструктивного апноэ сна</kwd><kwd>артериальная гипертензия</kwd><kwd>распространённость</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>焦虑</kwd><kwd>抑郁</kwd><kwd>睡眠障碍</kwd><kwd>呼吸暂停</kwd><kwd>阻塞性睡眠呼吸暂停综合征</kwd><kwd>高血压</kwd><kwd>流行率</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Drapkina OM, Shishkova VM, Kotova MB. 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