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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">643537</article-id><article-id pub-id-type="doi">10.17816/humeco643537</article-id><article-id pub-id-type="edn">WCVHEG</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Artificial intelligence technologies in biomedical research on human adaptation and maladaptation to environmental factors</article-title><trans-title-group xml:lang="ru"><trans-title>Технологии искусственного интеллекта в медико-биологических исследованиях адаптации и дезадаптации человека к различным факторам среды</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>人工智能技术在医学-生物学研究中用于分析人类对不同环境因素的适应与失调</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3400-9523</contrib-id><contrib-id contrib-id-type="spin">3434-2440</contrib-id><name-alternatives><name xml:lang="en"><surname>Balunov</surname><given-names>Ilya O.</given-names></name><name xml:lang="ru"><surname>Балунов</surname><given-names>Илья Олегович</given-names></name><name xml:lang="zh"><surname>Balunov</surname><given-names>Ilya O.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ilya@balunov.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4028-6405</contrib-id><contrib-id contrib-id-type="spin">2134-6830</contrib-id><name-alternatives><name xml:lang="en"><surname>Mikhalishchina</surname><given-names>Alina S.</given-names></name><name xml:lang="ru"><surname>Михалищина</surname><given-names>Алина Сергеевна</given-names></name><name xml:lang="zh"><surname>Mikhalishchina</surname><given-names>Alina S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>alina.mikhalishchina@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8960-5772</contrib-id><contrib-id contrib-id-type="spin">8881-1892</contrib-id><name-alternatives><name xml:lang="en"><surname>Venerin</surname><given-names>Andrey А.</given-names></name><name xml:lang="ru"><surname>Венерин</surname><given-names>Андрей Андреевич</given-names></name><name xml:lang="zh"><surname>Venerin</surname><given-names>Andrey А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerin.andrey@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9960-6608</contrib-id><contrib-id contrib-id-type="spin">6168-2110</contrib-id><name-alternatives><name xml:lang="en"><surname>Glazachev</surname><given-names>Oleg S.</given-names></name><name xml:lang="ru"><surname>Глазачев</surname><given-names>Олег Станиславович</given-names></name><name xml:lang="zh"><surname>Glazachev</surname><given-names>Oleg S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>glazachev@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution></aff><aff><institution xml:lang="zh">N.I. Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff><aff><institution xml:lang="zh">I.M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-05-03" publication-format="electronic"><day>03</day><month>05</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-07-19" publication-format="electronic"><day>19</day><month>07</month><year>2025</year></pub-date><volume>32</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>7</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2024-12-28"><day>28</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-04-02"><day>02</day><month>04</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/643537">https://hum-ecol.ru/1728-0869/article/view/643537</self-uri><abstract xml:lang="en"><p>The number of environmental factors simultaneously affecting the human body is extremely large. Tracking these factors in time has become possible thanks to the development of artificial intelligence technologies, including machine learning algorithms, deep learning algorithms, and generative artificial intelligence. The integration of this new generation of technological solutions into biomedical sciences enables the identification of hidden interdependencies among studied elements and processes that were previously overlooked. In the context of research on the mechanisms of human adaptation and maladaptation, special attention should be given to exogenous hypoxia as one of the most significant environmental factors studied within ecology, physiology, and clinical medicine. The topic of individual markers of human resistance to hypoxia remains open and is regularly addressed in physiological and pathophysiological works. In recent works, methods of machine and deep learning have already found wide application, including the analysis of multimodal physiological data. For example, a machine learning model has been developed to predict the development of acute mountain sickness with a sensitivity of 0.998 and a specificity of 0.978. The model was trained using physiological indicators of test subjects and real-time climate data. Thus, the application of artificial intelligence tools for scientific research planning, data processing, and the creation of predictive models significantly expands the current understanding of physiological mechanisms of human adaptation to hypoxia and enables the analysis of other environmental factors to be carried out at a new technological level.</p></abstract><trans-abstract xml:lang="ru"><p>Количество факторов внешней среды, воздействующих на человека одномоментно, чрезвычайно велико. Отслеживание их в динамике стало возможно благодаря развитию технологий искусственного интеллекта, включая алгоритмы машинного обучения, глубокого обучения и генеративный искусственный интеллект. Внедрение данного спектра технологических решений нового поколения в медико-биологические науки позволяет обнаруживать неявные взаимозависимости исследуемых элементов и процессов, упускаемые ранее. В контексте исследований механизмов адаптации и дезадаптации человека особое внимание следует уделить экзогенной гипоксии как одному из наиболее значимых факторов внешний среды, исследуемых в рамках экологии, физиологии и клинической медицины. Тема индивидуальных маркеров устойчивости человека к гипоксии до сих пор остаётся открытой и регулярно освещаемой в физиологических и патофизиологических работах. В последних методы машинного и глубокого обучения уже нашли широкое применение, включая анализ мультимодальных физиологических данных. Например, разработана модель машинного обучения, прогнозирующая развитие острой горной болезни с чувствительностью 0,998 и специфичностью 0,978. Для обучения модели использовались физиологические показатели испытуемых и климатические данные, фиксируемые в режиме реального времени. Таким образом, применение инструментов искусственного интеллекта для планирования научных исследований, обработки полученных данных и создания прогностических моделей существенно расширяет горизонт актуального понимания физиологических механизмов адаптации человека к гипоксии и позволяет на новом технологическом уровне подойти к анализу других факторов внешней среды.</p></trans-abstract><trans-abstract xml:lang="zh"><p>在同一时刻作用于人体的环境因素数量极为庞大。随着人工智能技术的发展，特别是机器学习、深度学习以及生成式人工智能算法的广泛应用，动态监测这些因素已成为可能。新一代人工智能解决方案在医学-生物学研究中的引入，使得研究者能够识别出此前未被发现的研究要素与生理过程之间的隐性相互关系。在探讨人类对环境适应与失调机制的研究背景下，外源性低氧应作为生态学、生理学及临床医学中最重要的环境因素之一被重点关注。个体对低氧耐受的标志物仍是一个开放性议题，至今仍频繁出现在生理学和病理生理学研究中。机器学习和深度学习方法已被广泛应用于该领域，尤其是在多模态生理数据的分析方面。例如，研究人员已构建出一种预测急性高原病发生的机器学习模型，其灵敏度达0.998，特异性为0.978。该模型基于受试者的生理参数与实时采集的气候数据进行训练。因此，在科研设计、数据处理和预测建模过程中应用人工智能工具，显著拓宽了对人体低氧适应生理机制的当前认识，并使我们能够在新的技术层面上开展对其他环境因素的分析。</p></trans-abstract><kwd-group xml:lang="en"><kwd>artificial intelligence</kwd><kwd>environmental factors</kwd><kwd>hypoxia</kwd><kwd>machine learning</kwd><kwd>adaptation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>факторы среды</kwd><kwd>гипоксия</kwd><kwd>машинное обучение</kwd><kwd>адаптация</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>人工智能</kwd><kwd>环境因素</kwd><kwd>低氧</kwd><kwd>机器学习</kwd><kwd>适应</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Analytical report on the publication activity of Russian specialists at conferences in the field of artificial intelligence level A for the period from 2019 to 2023, part 1 (NCRII) [Internet]. Moscow: AI.GOV.RU; 2024 [cited 2025 Jan 24]. Available from: https://ai.gov.ru/knowledgebase/investitsionnaya-aktivnost/2024_analiticheskiy_otchet_po_publikacionnoy_aktivnosti_rossiyskih_specialistov_na_konferenciyah_v_oblasti_iskusstvennogo_intellekta_urovnya_a_za_period_s_2019_g_po_2023_g_chasty_1_ncrii/</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Babu M, Lautman Z, Lin X, et al. Wearable devices: implications for precision medicine and the future of health care. Annu Rev Med. 2024;75:401–415. doi: 10.1146/annurev-med-052422-020437</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>SberMed. How digital physician assistants Top 3 and Aida help Moscow doctors [Internet]. 2023 Feb 9 [cited 2025 Jan 24]. Available from: https://sbermed.ai/kak-cifrovye-pomoschniki-vracha-top-3-i-aida-pomogayut-moskovskim-vracham</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Rashidi HH, Pantanowitz J, Chamanzar A, et al. Generative artificial intelligence in pathology and medicine: a deeper dive. Mod Pathol. 2025;38(4):100687. doi: 10.1016/j.modpat.2024.100687</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Boscardin CK, Gin B, Golde PB, Hauer KE. ChatGPT and generative artificial intelligence for medical education: potential impact and opportunity. Acad Med. 2024;99(1):22–27. doi: 10.1097/ACM.0000000000005439</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Doron G, Genway S, Roberts M, Jasti S. Generative AI: driving productivity and scientific breakthroughs in pharmaceutical R&amp;D. Drug Discov Today. 2025;30(1):104272. doi: 10.1016/j.drudis.2024.104272</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mojadeddi ZM, Rosenberg J. AI in medical research. Ugeskr Laeger. 2024;186(16):V08230532. doi: 10.61409/V08230532</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lenta.ru. Giga Chat passed the doctor's exam [Internet]. 2024 Feb 13 [cited 2025 Jan 24]. Available from: https://lenta.ru/news/2024/02/13/vracha/</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Ong CS, Burattini L, Schena S. Editorial: Artificial intelligence in human physiology. Front Physiol. 2022;13:1075819. doi: 10.3389/fphys.2022.1075819</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Cherkasov DYu, Ivanov VV. Machine learning. Science, Technology and Education. 2018;(5):85–87. EDN: XOPNID</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>LeCun Y, Bengio Y, Hinton G. Deep learning. Nature. 2015;521(7553):436–444. doi: 10.1038/nature14539</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Vaswani N, Shazeer N, Parmar J, et al. Attention is all you need. Neural Information Processing Systems. 2017;(30):5998–6008.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Elyan E, Vuttipittayamongkol P, Johnston P, et al. Computer vision and machine learning for medical image analysis: recent advances, challenges, and way forward. Art Int Surg. 2022;2:24–45. doi 10.20517/ais.2021.15</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Kelly BS, Judge C, Bollard SM, et al. Radiology artificial intelligence: a systematic review and evaluation of methods (RAISE). Eur Radiol. 2022;32(11):7998–8007. doi: 10.1007/s00330-022-08784-6</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Grzybowski A, Jin K, Zhou J, et al. Retina fundus photograph-based artificial intelligence algorithms in medicine: a systematic review. Ophthalmol Ther. 2024;13(8):2125–2149. doi: 10.1007/s40123-024-00981-4</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Beltrami EJ, Brown AC, Salmon PJM, et al. Artificial intelligence in the detection of skin cancer. J Am Acad Dermatol. 2022;87(6):1336–1342. doi: 10.1016/j.jaad.2022.08.028</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Niazi MKK, Parwani AV, Gurcan MN. Digital pathology and artificial intelligence. Lancet Oncol. 2019;20(5):e253–e261. doi: 10.1016/S1470-2045(19)30154-8</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Hassan C, Spadaccini M, Iannone A, et al. Performance of artificial intelligence in colonoscopy for adenoma and polyp detection: a systematic review and meta-analysis. Gastrointest Endosc. 2021;93(1):77–85.e6. doi: 10.1016/j.gie.2020.06.059</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Attia ZI, Harmon DM, Behr ER, Friedman PA. Application of artificial intelligence to the electrocardiogram. Eur Heart J. 2021;42(46):4717–4730. doi: 10.1093/eurheartj/ehab649</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Gusev AV, Artemova OR, Vasiliev YuA, Vladzymyrskyy AV. Integration of AI-based software as a medical device into Russian healthcare system: results of 2023. National Health Care (Russia). 2024;5(2):17–24. doi: 10.47093/2713-069X.2024.5.2.17-24</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Lee S, Kim HS. Prospect of artificial intelligence based on electronic medical record. J Lipid Atheroscler. 2021;10(3):282–290. doi: 10.12997/jla.2021.10.3.282</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Juhn Y, Liu H. Artificial intelligence approaches using natural language processing to advance EHR-based clinical research. J Allergy Clin Immunol. 2020;145(2):463–469. doi: 10.1016/j.jaci.2019.12.897</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Datta S, Bernstam EV, Roberts K. A frame semantic overview of NLP-based information extraction for cancer-related EHR notes. J Biomed Inform. 2019;100:103301. doi: 10.1016/j.jbi.2019.103301</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Fu S, Lopes GS, Pagali SR, et al. Ascertainment of delirium status using natural language processing from electronic health records. J Gerontol A Biol Sci Med Sci. 2022;77(3):524–530. doi: 10.1093/gerona/glaa275</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Topol EJ. As artificial intelligence goes multimodal, medical applications multiply. Science. 2023;381(6663):adk6139. doi: 10.1126/science.adk6139</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Ralevski A, Taiyab N, Nossal M, et al. Using large language models to abstract complex social determinants of health from original and deidentified medical notes: development and validation study. J Med Internet Res. 2024;26:e63445. doi: 10.2196/63445</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Hwang Y, Cornman AL, Kellogg EH, et al. Genomic language model predicts protein co-regulation and function. Nat Commun. 2024;15(1):2880. doi: 10.1038/s41467-024-46947-9</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Rossi SH, Newsham I, Pita S, et al. Accurate detection of benign and malignant renal tumor subtypes with MethylBoostER: An epigenetic marker–driven learning framework. Sci Adv. 2022;8(39):eabn9828. doi: 10.1126/sciadv.abn9828</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Jumper J, Evans R, Pritzel A, et al. Highly accurate protein structure prediction with AlphaFold. Nature. 2021;596(7873):583–589. doi: 10.1038/s41586-021-03819-2</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Abramson J, Adler J, Dunger J, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024;630(8016):493–500. doi: 10.1038/s41586-024-07487-w</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Singh S, Kaur N, Gehlot A. Application of artificial intelligence in drug design: A review. Comput Biol Med. 2024;179:108810. doi: 10.1016/j.compbiomed.2024.108810</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Kung TH, Cheatham M, Medenilla A, et al. Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models. PLOS Digital Health. 2023;2(2):e0000198. doi: 10.1371/journal.pdig.0000198</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Lee P, Bubeck S, Petro J. Benefits, limits, and risks of GPT-4 as an AI chatbot for medicine. N Engl J Med. 2023;388(13):1233–1239. doi: 10.1056/NEJMsr2214184</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>CNews. Sechenov University developed an algorithm for diagnosing cardiovascular diseases using artificial intelligence [Internet]. 2024 Dec 25 [cited 2025 Jan 24]. Available from: https://corp.cnews.ru/news/line/2024-12-25_sechenovskij_universitet</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Leo AJ, Schuelke MJ, Hunt DM, et al. Digital mental health intervention plus usual care compared with usual care only and usual care plus in-person psychological counseling for orthopedic patients with symptoms of depression or anxiety: cohort study. JMIR Form Res. 2022;6(5):e36203. doi: 10.2196/36203</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Wei Z, Iyer MR, Zhao B, et al. Artificial intelligence-assisted comparative analysis of the overlapping molecular pathophysiology of alzheimer’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia. Int J Mol Sci. 2024;25(24):13450. doi: 10.3390/ijms252413450</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Asencio A, Malingen S, Kooiker KB, et al. Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations. Journal of General Physiology. 2023;155(5):e202213291. doi: 10.1085/jgp.202213291</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Peng D, Yue H, Tan W, et al. A bimodal feature fusion convolutional neural network for detecting obstructive sleep apnea/hypopnea from nasal airflow and oximetry signals. Artif Intell Med. 2024;150:102808. doi: 10.1016/j.artmed.2024.102808</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Rush B, Celi LA, Stone DJ. Applying machine learning to continuously monitored physiological data. J Clin Monit Comput. 2019;33(5):887–893. doi: 10.1007/s10877-018-0219-z</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Cai S, Li H, Zheng F, et al. Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease. Proc Natl Acad Sci. 2021;118(13):e2100697118. doi: 10.1073/pnas.2100697118</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Soulage CO, Van Coppenolle F, Guebre-Egziabher F. The conversational AI “ChatGPT” outperforms medical students on a physiology university examination. Adv Physiol Educ. 2024;48(4):677–684. doi: 10.1152/advan.00181.2023</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Favero TG. Using artificial intelligence platforms to support student learning in physiology. Adv Physiol Educ. 2024;48(2):193–199. doi: 10.1152/advan.00213.2023</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Pereira MMCE, Padez CMP, Nogueira HGDSM. Describing studies on childhood obesity determinants by Socio-Ecological Model level: a scoping review to identify gaps and provide guidance for future research. Int J Obes. 2019;43(10):1883–1890. doi: 10.1038/s41366-019-0411-3</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Allen B, Lane M, Steeves EA, Raynor H. Using explainable artificial intelligence to discover interactions in an ecological model for obesity. Int J Environ Res Public Health. 2022;19(15):9447. doi: 10.3390/ijerph19159447</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Ojha KV, Griego DM, Kuliga S, et al. Machine learning approaches to understand the influence of urban environments on human´s physiological response. Information Sciences, 2019;474:154–169. doi: 10.1016/j.ins.2018.09.061</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Wei CY, Chen PN, Lin SS, et al. Using machine learning to determine the correlation between physiological and environmental parameters and the induction of acute mountain sickness. BMC Bioinformatics. 2021;22(Suppl 5):628. doi: 10.1186/s12859-022-04749-0</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Shen Y, Liu C, He H, et al. Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate. Biosensors (Basel). 2022;12(12):1164. doi: 10.3390/bios12121164</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Kimball JP, Inan OT, Convertino VA, et al. Wearable sensors and machine learning for hypovolemia problems in occupational, military and sports medicine: physiological basis, hardware and algorithms. Sensors. 2022;22(2):442. doi: 10.3390/s22020442</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Westphal A, Mrowka R. Special issue European Journal of Physiology: Artificial intelligence in the field of physiology and medicine. Pflugers Arch. 2025;477(4):509–512. doi: 10.1007/s00424-025-03071-x</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Han J, Liu M, Shi J, Li Y. Construction of a machine learning model to estimate physiological variables of speed skating athletes under hypoxic training conditions. J Strength Cond Res. 2023;37(7):1543–1550. doi: 10.1519/JSC.0000000000004058</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Snider DH, Linnville SE, Phillips JB, Rice GM. Predicting hypoxic hypoxia using machine learning and wearable sensors. Biomed Signal Process Control. 2022;71:103110. doi: 10.1016/j.bspc.2021.103110</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Mazing MS, Zaitceva AY, Davydov RV. Application of the Kohonen neural network for monitoring tissue oxygen supply under hypoxic conditions. J Phys. 2021;2086:012116. doi: 10.1088/1742-6596/2086/1/012116</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Dzhalilova D, Makarova O. Differences in tolerance to hypoxia: physiological, biochemical, and molecular-biological characteristics. Biomedicines. 2020;8(10):428. doi: 10.3390/biomedicines8100428</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Leveque C, Mrakic Sposta S, Theunissen S, et al. Oxidative stress response kinetics after 60 minutes at different levels (10% or 15%) of normobaric hypoxia exposure. Int J Mol Sci. 2023;24(12):10188. doi: 10.3390/ijms241210188</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Zembron-Lacny A, Tylutka A, Wacka E, et al. Intermittent hypoxic exposure reduces endothelial dysfunction. Biomed Res Int. 2020;2020:6479630. doi: 10.1155/2020/6479630</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Hafner S, Beloncle F, Koch A, et al. Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update. Ann Intensive Care. 2015;5(1):42. doi: 10.1186/s13613-015-0084-6</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Gorni D, Finco A. Oxidative stress in elderly population: A prevention screening study. Aging Medicine. 2020;3(3):205–213. doi: 10.1002/agm2.12121</mixed-citation></ref></ref-list></back></article>
