<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">689971</article-id><article-id pub-id-type="doi">10.17816/humeco689971</article-id><article-id pub-id-type="edn">GLKXMS</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDY ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Implementing digital technologies in microbiological monitoring and antimicrobial resistance assessment in intensive care units</article-title><trans-title-group xml:lang="ru"><trans-title>Применение цифровых технологий для организации системы микробиологического мониторинга и оценки антибактериальной резистентности в отделениях интенсивной терапии</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>基于数字技术的重症监护病房微生物学监测与抗菌耐药性评估体系</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1484-8251</contrib-id><contrib-id contrib-id-type="spin">9368-7627</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironenko</surname><given-names>Olga V.</given-names></name><name xml:lang="ru"><surname>Мироненко</surname><given-names>Ольга Васильевна</given-names></name><name xml:lang="zh"><surname>Mironenko</surname><given-names>Olga V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>miroolga@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8624-6452</contrib-id><contrib-id contrib-id-type="spin">8849-3830</contrib-id><name-alternatives><name xml:lang="en"><surname>Buzinov</surname><given-names>Roman V.</given-names></name><name xml:lang="ru"><surname>Бузинов</surname><given-names>Роман Вячеславович</given-names></name><name xml:lang="zh"><surname>Buzinov</surname><given-names>Roman V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine)</p></bio><email>r.buzinov@s-znc.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4137-8259</contrib-id><contrib-id contrib-id-type="spin">7687-4489</contrib-id><name-alternatives><name xml:lang="en"><surname>Tovanova</surname><given-names>Anna A.</given-names></name><name xml:lang="ru"><surname>Тованова</surname><given-names>Анна Александровна</given-names></name><name xml:lang="zh"><surname>Tovanova</surname><given-names>Anna A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>ann.tovan@bk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">4643-5110</contrib-id><name-alternatives><name xml:lang="en"><surname>Kovalenko</surname><given-names>Igor Yu.</given-names></name><name xml:lang="ru"><surname>Коваленко</surname><given-names>Игорь Юрьевич</given-names></name><name xml:lang="zh"><surname>Kovalenko</surname><given-names>Igor Yu.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>igorkovalenko022@yandex.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">8923-3499</contrib-id><name-alternatives><name xml:lang="en"><surname>Petrova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Петрова</surname><given-names>Елена Аркадьевна</given-names></name><name xml:lang="zh"><surname>Petrova</surname><given-names>Elena A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>petrova_epid@mail.ru</email><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-9486-2519</contrib-id><name-alternatives><name xml:lang="en"><surname>Selnitseva</surname><given-names>Victoria V.</given-names></name><name xml:lang="ru"><surname>Сельницева</surname><given-names>Виктория Владиславовна</given-names></name><name xml:lang="zh"><surname>Selnitseva</surname><given-names>Victoria V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>selavik@mail.ru</email><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5727-8965</contrib-id><contrib-id contrib-id-type="spin">2352-2471</contrib-id><name-alternatives><name xml:lang="en"><surname>Podboronov</surname><given-names>Mikhail I.</given-names></name><name xml:lang="ru"><surname>Подборонов</surname><given-names>Михаил Игоревич</given-names></name><name xml:lang="zh"><surname>Podboronov</surname><given-names>Mikhail I.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>podboronov.misha@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0933-7972</contrib-id><contrib-id contrib-id-type="spin">3602-8316</contrib-id><name-alternatives><name xml:lang="en"><surname>Butskaya</surname><given-names>Maria Yu.</given-names></name><name xml:lang="ru"><surname>Буцкая</surname><given-names>Мария Юрьевна</given-names></name><name xml:lang="zh"><surname>Butskaya</surname><given-names>Maria Yu.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>butskaya.masha@yandex.ru</email><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">North-Western State Medical University n.a. I.I. Mechnikova</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff><aff><institution xml:lang="zh">North-Western State Medical University n.a. I.I. Mechnikova</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Saint-Petersburg State University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет</institution></aff><aff><institution xml:lang="zh">Saint-Petersburg State University</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">My Medical Center</institution></aff><aff><institution xml:lang="ru">Мой медицинский центр</institution></aff><aff><institution xml:lang="zh">My Medical Center</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Northwest Hygiene and Public Health Research Center</institution></aff><aff><institution xml:lang="ru">Северо-Западный научный центр гигиены и общественного здоровья</institution></aff><aff><institution xml:lang="zh">Northwest Hygiene and Public Health Research Center</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Dental clinic No. 32, St. Petersburg</institution></aff><aff><institution xml:lang="ru">Стоматологическая поликлиника № 32, Санкт-Петербург</institution></aff><aff><institution xml:lang="zh">Dental clinic No. 32, St. Petersburg</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">City Hospital No. 26, St. Petersburg</institution></aff><aff><institution xml:lang="ru">Городская больница № 26, Санкт-Петербург</institution></aff><aff><institution xml:lang="zh">City Hospital No. 26, St. Petersburg</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">City Multidisciplinary Hospital No. 2, St. Petersburg</institution></aff><aff><institution xml:lang="ru">Городская многопрофильная больница № 2, Санкт-Петербург</institution></aff><aff><institution xml:lang="zh">City Multidisciplinary Hospital No. 2, St. Petersburg</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-11-14" publication-format="electronic"><day>14</day><month>11</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-12-22" publication-format="electronic"><day>22</day><month>12</month><year>2025</year></pub-date><volume>32</volume><issue>11</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>822</fpage><lpage>831</lpage><history><date date-type="received" iso-8601-date="2025-08-29"><day>29</day><month>08</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-29"><day>29</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/689971">https://hum-ecol.ru/1728-0869/article/view/689971</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND: </bold>Healthcare-associated infections remain a major challenge of modern medical practice, with multidrug-resistant strains representing the most clinically significant pathogens. A central problem is the widespread dissemination of <italic>Klebsiella pneumoniae</italic> in intensive care units. This prevalence is associated with the severe condition of patients, for whom infection with multidrug-resistant strains exacerbates the underlying disease, extends the duration of therapy, and results in a significant economic burden. Systematic microbiological monitoring and evaluation of the antimicrobial resistance of strains isolated from patient biological specimens are key elements of healthcare-associated infection control in inpatient healthcare settings.</p> <p><bold>AIM:</bold> This work aimed to perform a comparative analysis of the microbiological landscape and antimicrobial resistance patterns of multidrug-resistant isolates using modern digital technologies in the intensive care and cardiac intensive care units of two multidisciplinary hospitals in Saint Petersburg.</p> <p><bold>METHODS: </bold>A retrospective analysis was conducted using microbiological surveillance data from the intensive care units and cardiac intensive care units of two multidisciplinary hospitals in Saint Petersburg for 2024. The obtained data were processed using the analytical software WHONET and the online platform AMRCloud.</p> <p><bold>RESULTS: </bold>ESCAPE pathogens were the predominant microorganisms isolated from sputum and bronchoalveolar lavage in both intensive care units and cardiac intensive care units. A statistically significant higher level of resistance among these isolates was observed in intensive care units compared with cardiac intensive care units. To analyze the prevalence of ventilator-associated pneumonia, we calculated stratified epidemiological indicators. The results were consistent with the published data.</p> <p><bold>CONCLUSION: </bold>Regular microbiological monitoring is a key tool for controlling healthcare-associated pathogens and tracking their antimicrobial resistance in a hospital setting. This monitoring enables a timely response to shifts in the epidemiological situation, including changes in microbial profile, the emergence of new strain associations, and their resistance to antibacterial agents. Such work is inherently linked to the rapid analysis of large datasets, which necessitates the development of new digital technologies for integration into hospital information systems.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Одной из серьёзных проблем современного здравоохранения являются инфекции, связанные с оказанием медицинской помощи, при которых в качестве приоритетных возбудителей выступают полирезистентные штаммы. Наибольшей актуальностью характеризуется широкое распространение штаммов <italic>Klebsiella pneumoniae</italic> в отделениях интенсивной терапии, связанное с тяжёлым состоянием пациентов, для которых инфицирование полирезистентными штаммами усугубляет течение основного заболевания, увеличивает длительность лечения, приводит к существенному экономическому ущербу. Важными элементами организации контроля за инфекциями, связанными с оказанием медицинской помощи в стационаре, являются систематический микробиологический мониторинг и оценка антибактериальной резистентности штаммов, выделенных из биологического материала пациентов.</p> <p><bold>Цель. </bold>Сравнительная характеристика микробиологического пейзажа и антибиотикорезистентности выделенных полирезистентных штаммов на основе современных цифровых технологий у пациентов отделений реанимации и кардиореанимации двух многопрофильных стационаров Санкт-Петербурга.</p> <p><bold>Методы.</bold> Проведён ретроспективный анализ результатов микробиологического мониторинга отделений реанимации и кардиореанимации двух многопрофильных стационаров Санкт-Петербурга за 2024 г. Полученные данные обрабатывали при помощи компьютерной аналитической программы WHONET и онлайн-платформы AMRCloud.</p> <p><bold>Результаты. </bold>Основное место в структуре микроорганизмов отделений реанимации и кардиореанимации занимает группа ESCAPE-патогенов, выделенных из мокроты и смывов из бронхоальвеолярного лаважа пациентов. Выявлен статистически значимый более высокий уровень резистентности данных штаммов в отделениях реанимации по сравнению с отделениями кардиореанимации. Для анализа уровня распространённости пневмоний, ассоциируемых с искусственной вентиляцией лёгких, проведен расчёт стратифицированных эпидемиологических показателей, результаты которого соответствуют данным, полученным из литературных источников.</p> <p><bold>Заключение. </bold>Одним из основных инструментов по контролю за возбудителями инфекций, связанных с оказанием медицинской помощи в стационаре, динамикой их антибиотикорезистентности является регулярно проводимый микробиологический мониторинг, который позволяет своевременно реагировать на изменяющуюся эпидемиологическую ситуацию, структуру микроорганизмов, образующиеся ассоциации штаммов, их резистентность к антибактериальным препаратам. Данная работа неотъемлемо связана с быстрым анализом большого массива данных, что требует разработки новых цифровых технологий для внедрения их в медицинские информационные системы стационаров.</p></trans-abstract><trans-abstract xml:lang="zh"><p>论证。医疗相关感染是当代卫生保健体系的一项严重问题，其中以多重耐药菌株为主要致病因子。重症监护病房中<italic>Klebsiella pneumoniae</italic>的广泛流行尤具临床关注意义，因为在病情危重的患者中，感染多重耐药菌株会加重基础疾病进程、延长治疗时间并造成显著的经济损失。系统性的微生物学监测以及对患者生物材料中分离菌株抗菌耐药性的评估，是医疗相关感染防控体系的重要组成部分。</p> <p>目的。基于现代数字技术，对Saint Petersburg两家综合医院重症监护病房与心脏重症监护病房中分离的多重耐药菌株的微生物谱及抗菌耐药性进行比较分析。</p> <p>方法。对Saint Petersburg两家综合性医院重症监护病房和心脏重症监护病房2024年度的微生物学监测结果进行了回顾性分析。所得数据采用计算机分析程序WHONET和在线平台 AMRCloud进行处理。</p> <p>结果。重症监护病房和心脏重症监护病房中分离的微生物以ESCAPE病原体占主导，主要来源为痰液及支气管肺泡灌洗液。重症监护病房菌株的耐药水平显著高于 心脏重症监护病房。为分析与机械通气相关性肺炎的流行情况，计算了分层流行病学指标，其结果与文献数据一致。</p> <p>结论。定期开展的微生物学监测是控制住院医疗相关感染致病菌及其抗菌耐药性动态的主要工具之一，它能够及时应对不断变化的流行病学形势，了解微生物结构、形成的菌株联合及其对抗菌药物的耐药性。由于该工作与大量数据的快速分析密切相关，亟需开发并将新的数字技术应用于医院信息系统中。</p></trans-abstract><kwd-group xml:lang="en"><kwd>healthcare-associated infections</kwd><kwd>microbiological monitoring</kwd><kwd>intensive care unit</kwd><kwd>cardiac intensive care unit</kwd><kwd>microbial strains</kwd><kwd>Klebsiella pneumoniae</kwd><kwd>antimicrobial resistance</kwd><kwd>empirical and rational antibiotic therapy</kwd><kwd>digital technologies</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфекции, связанные с оказанием медицинской помощи</kwd><kwd>микробиологический мониторинг</kwd><kwd>отделение реанимации и интенсивной терапии</kwd><kwd>отделение кардиореанимации</kwd><kwd>штаммы микроорганизмов</kwd><kwd>Klebsiella pneumoniae</kwd><kwd>антибиотикорезистентность</kwd><kwd>эмпирическая и рациональная антибиотикотерапия</kwd><kwd>цифровые технологии</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>医疗相关感染</kwd><kwd>微生物学监测</kwd><kwd>重症监护病房</kwd><kwd>心脏重症监护病房</kwd><kwd>微生物菌株</kwd><kwd>Klebsiella pneumoniae</kwd><kwd>抗菌耐药性</kwd><kwd>经验性与合理抗菌治疗</kwd><kwd>数字技术</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Prin M, Li G. Complications and in-hospital mortality in trauma patients treated in intensive care units in the United States, 2013. Inj Epidemiol. 2016;3(1):18. doi: 10.1186/s40621-016-0084-5</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Fan P, Fu P, Liu J, et al. Monitoring of Klebsiella pneumoniae infection and drug resistance in 17 pediatric intensive care units in China from 2016 to 2022. Infect Drug Resist. 2024;17:4125–4136. doi: 10.2147/IDR.S475720</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Lohiya R, Deotale V. Surveillance of health-care associated infections in an intensive care unit at a tertiary care hospital in Central India. GMS Hyg Infect Control. 2023;18:Doc28. doi: 10.3205/dgkh000454</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Nabieva AS, Aslanov BI, Nokhrin AV. Risk factors for healthcare-associated infections in pediatric cardiac surgery. Public Health and Life Environment — PH&amp;LE. 2022;30(11):69–75. doi: 10.35627/2219-5238/2022-30-11-69-75 EDN: YLLRXY</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Venkateswaran P, Vasudevan S, David H, et al. Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing. Front Cell Infect Microbiol. 2023;13:1159798. doi: 10.3389/fcimb.2023.1159798</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Teng J, Imani S, Zhou A, et al. Combatting resistance: Understanding multi-drug resistant pathogens in intensive care units. Biomed Pharmacother. 2023;167:115564. doi: 10.1016/j.biopha.2023.115564</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Goloverova, YuA, Akimkin VG. Prospects of epidemiological investigation of outbreaks caused by the ESCAPE group of bacteria among patients of intensive care units and intensive care units. In: From the theory of self-regulation to global self-isolation: modern challenges to epidemiological science and practice: Collection of articles of the All-Russian interdepartmental scientific and practical conference dedicated to the 100th anniversary of the birth of Academician. St. Petersburg: S.M. Kirov Military Medical Academy; 2022. P. 44–49. EDN SQESRZ</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>De Oliveira DMP, Forde BM, Kidd TJ, et al. Antimicrobial resistance in ESKAPE pathogens. Clin Microbiol Rev. 2020;33(3):e00181–00119. doi: 10.1128/CMR.00181-19</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Kireev SS, Matveenkova LV. Intensive therapy of the intrahospital infection in office of reanimation and intensive therapy. Journal of New Medical Technologies. 2014;21(4):92–97. doi: 10.12737/7277 EDN: RHHWIU</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Orlova OA, Akimkin VG. Organization of epidemiological diagnosis of ventilator-associated respiratory infections. Medical Alphabet. 2017;3(30):15–19. EDN: ZVGRQJ</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Zueva LP, Aslanov BI, Vasiliev KD, et al. Epidemiological diagnostics — basis of risk-oriented technologies for the prevention healthcare-associated infections. Epidemiology and Vaccinal Prevention. 2017;16(5):69–74. doi: 10.31631/2073-3046-2017-16-5-69-74 EDN: ZQOLTT</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Charles MP, Kali A, Easow JM, et al. Ventilator-associated pneumonia. Australas Med J. 2014;7(8):334–44. doi: 10.4066/AMJ.2014.2105</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Mumtaz H, Saqib M, Khan W, et al. Ventilator associated pneumonia in intensive care unit patients: a systematic review. Ann Med Surg (Lond). 2023;85(6):2932–2939. doi: 10.1097/MS9.0000000000000836</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Timsit JF, Esaied W, Neuville M, et al. Update on ventilator-associated pneumonia. F1000Res. 2017;6:2061. doi: 10.12688/f1000research.12222.1</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Baigenzhin A, Bissenova N, Yergaliyeva A, et al. ESKAPE pathogens in pediatric cardiac surgery patients: 5-year microbiological monitoring in a tertiary hospital in Kazakhstan. Acta Microbiol Immunol Hung. 2024;71(3):211–219. doi: 10.1556/030.2024.02352</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Fernández-Martínez NF, Cárcel-Fernández S, De la Fuente-Martos C, et al. Risk factors for multidrug-resistant gram-negative bacteria carriage upon admission to the intensive care unit. Int J Environ Res Public Health. 2022;19(3):1039. doi: 10.3390/ijerph19031039</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ali HS, Khan FY, George S, et al. Epidemiology and Outcome of ventilator-associated pneumonia in a heterogeneous ICU population in Qatar. Biomed Res Int. 2016;2016:8231787. doi: 10.1155/2016/8231787</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Li Y, Liu C, Xiao W, et al. Incidence, Risk factors, and outcomes of ventilator-associated pneumonia in traumatic brain injury: a meta-analysis. Neurocrit Care. 2020;32(1):272–285. doi: 10.1007/s12028-019-00773-w</mixed-citation></ref></ref-list></back></article>
