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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">698526</article-id><article-id pub-id-type="doi">10.17816/humeco698526</article-id><article-id pub-id-type="edn">TNYIWT</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Human biorhythms and their monitoring using biological fluid indicators</article-title><trans-title-group xml:lang="ru"><trans-title>Биоритмы человека и их мониторинг в показателях биологических жидкостей</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>人体生物节律及其在体液指标中的监测</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0501-0570</contrib-id><contrib-id contrib-id-type="spin">6150-3110</contrib-id><name-alternatives><name xml:lang="en"><surname>Anuchina</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Анучина</surname><given-names>Алевтина Викторовна</given-names></name><name xml:lang="zh"><surname>Anuchina</surname><given-names>A.</given-names></name></name-alternatives><email>the-first157@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4918-6937</contrib-id><contrib-id contrib-id-type="spin">9161-0264</contrib-id><name-alternatives><name xml:lang="en"><surname>Sarf</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Сарф</surname><given-names>Елена Александровна</given-names></name><name xml:lang="zh"><surname>Sarf</surname><given-names>E. A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sarf_ea@omgpu.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6147-4854</contrib-id><contrib-id contrib-id-type="spin">4189-7899</contrib-id><name-alternatives><name xml:lang="en"><surname>Bel'skaya</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Бельская</surname><given-names>Людмила Владимировна</given-names></name><name xml:lang="zh"><surname>Bel'skaya</surname><given-names>L. V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Chemistry)</p></bio><bio xml:lang="ru"><p>канд. хим. наук</p></bio><bio xml:lang="zh"><p>Cand. Sci. (Chemistry)</p></bio><email>belskaya@omgpu.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Omsk State Pedagogical University</institution></aff><aff><institution xml:lang="ru">Омский государственный педагогический университет</institution></aff><aff><institution xml:lang="zh">Omsk State Pedagogical University</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Omsk State Pedagogical University</institution></aff><aff><institution xml:lang="ru">Омский государственный педагогический университет</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-01-29" publication-format="electronic"><day>29</day><month>01</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-02-22" publication-format="electronic"><day>22</day><month>02</month><year>2026</year></pub-date><volume>33</volume><issue>1</issue><issue-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</issue-title><issue-title xml:lang="ru">Экология человека</issue-title><issue-title xml:lang="zh">Ekologiya cheloveka (Human Ecology)</issue-title><fpage>7</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2025-12-12"><day>12</day><month>12</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-01-21"><day>21</day><month>01</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/698526">https://hum-ecol.ru/1728-0869/article/view/698526</self-uri><abstract xml:lang="en"><p>Most physiological processes in the human body are governed by genetically determined biorhythms, which are key factors of natural selection and adaptation. Circadian rhythms regulate not only daily biological processes but also their underlying molecular basis. This knowledge may be useful for developing therapeutic strategies for a range of diseases. Particular importance is attributed to research in biological rhythms for professions involving shift work and night work, as it allows identifying periods of increased vulnerability of the human body. Changes in living, working, and rest conditions may lead to disturbances and disruptions of biological rhythms: the internal biological clock may accelerate or decelerate, resulting in desynchronization, deterioration of well-being, and the development of chronopathological conditions, including an increased risk of cardiovascular and endocrine disorders, psychoemotional disturbances, and reduced work capacity. Therefore, chronomedicine addresses the application of knowledge about biorhythm patterns for the prevention, diagnosis, and treatment of human diseases. Monitoring of human biorhythms can be performed using various biological fluids (blood, urine, saliva), depending on the research objectives and laboratory capabilities.</p></abstract><trans-abstract xml:lang="ru"><p>Большинство процессов в организме человека подчинено наследственно закреплённым биоритмам — важнейшим факторам естественного отбора и адаптации. Циркадные ритмы регулируют не только повседневные биологические процессы, но и их молекулярную основу. Это знание может быть полезным для разработки стратегий лечения ряда заболеваний. Особенно важно учитывать исследования в области биоритмологии в профессиях, связанных с круглосуточной работой и ночным трудом, для выявления периодов наибольшей поражаемости организма человека. С изменением условий жизни, труда и отдыха происходят нарушения и сбой биологических ритмов: биологические часы организма начинают спешить или отставать, приводя к десинхронизации, вследствие чего ухудшается самочувствие и возникают хронопатологии, а именно увеличивается риск кардиологических, эндокринных проблем, а также психоэмоциональных нарушений и снижения работоспособности. Именно поэтому хрономедицина ставит перед собой вопросы использования знаний о закономерностях биоритмов для профилактики, диагностики и лечения заболеваний человека. Мониторинг биоритмов организма человека возможен по ряду биологических жидкостей (крови, моче, слюне) в соответствии с поставленными задачами и лабораторными возможностями.</p></trans-abstract><trans-abstract xml:lang="zh"><p>大多数人体内的过程都遵循遗传固定的生物节律——自然选择和适应的重要因素。昼夜节律不仅调节日常生物过程，还调节其分子基础。这一知识可能对开发一系列疾病的治疗策略有用。特别是在涉及24小时工作和夜间工作的职业中，考虑生物节律学研究对于识别人体最易受影响的时期尤为重要。随着生活、工作和休息条件的变化，生物节律发生紊乱和失调：生物钟开始快或慢，导致不同步，从而导致健康状况恶化和时间病理学的出现，即心脏、内分泌问题的风险增加，以及心理情绪障碍和工作能力下降。因此，时间医学提出了利用生物节律规律知识进行疾病预防、诊断和治疗的问题。根据设定的任务和实验室的可能性，可以通过一系列生物液体（血液、尿液、唾液）监测人体的生物节律。</p></trans-abstract><kwd-group xml:lang="en"><kwd>biological rhythms</kwd><kwd>hormones</kwd><kwd>electrolytes</kwd><kwd>blood</kwd><kwd>saliva</kwd><kwd>urine</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биологические ритмы</kwd><kwd>гормоны</kwd><kwd>электролиты</kwd><kwd>кровь</kwd><kwd>слюна</kwd><kwd>моча</kwd><kwd>обзор</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>生物节律激素</kwd><kwd>电解质</kwd><kwd>血液</kwd><kwd>唾液</kwd><kwd>尿液</kwd><kwd>综述</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Misnikova IV, Zoloeva DE. 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