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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">702109</article-id><article-id pub-id-type="doi">10.17816/humeco702109</article-id><article-id pub-id-type="edn">DSIQMW</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The potential of dihydroquercetin and other active substances in cosmetic products for regulating hair follicle activity in the periorbital region: a review</article-title><trans-title-group xml:lang="ru"><trans-title>Потенциал применения дигидрокверцетина и других активных веществ в составе косметических продуктов для регуляции активности волосяных фолликулов периорбитальной области: обзор литературы</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>二氢槲皮素及其他活性成分在化妆品中用于调节眼周区域毛囊活性的应用潜力：文献综述</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mindiyarova</surname><given-names>Alina V.</given-names></name><name xml:lang="ru"><surname>Миндиярова</surname><given-names>Алина Викторовна</given-names></name><name xml:lang="zh"><surname>Mindiyarova</surname><given-names>Alina V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mindiyarova.alina@almea.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinyakov</surname><given-names>Kirill O.</given-names></name><name xml:lang="ru"><surname>Синяков</surname><given-names>Кирилл Олегович</given-names></name><name xml:lang="zh"><surname>Sinyakov</surname><given-names>Kirill O.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kirill.sinyakov@almea.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0045-7046</contrib-id><contrib-id contrib-id-type="spin">3936-9293</contrib-id><name-alternatives><name xml:lang="en"><surname>Burenkov</surname><given-names>Evgeniy S.</given-names></name><name xml:lang="ru"><surname>Буренков</surname><given-names>Евгений Сергеевич</given-names></name><name xml:lang="zh"><surname>Burenkov</surname><given-names>Evgeniy S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Pharmacy)</p></bio><bio xml:lang="ru"><p>канд. фарм. наук</p></bio><bio xml:lang="zh"><p>Cand. Sci. (Pharmacy)</p></bio><email>burenkov@reaviz.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5464-0498</contrib-id><contrib-id contrib-id-type="spin">5118-0081</contrib-id><name-alternatives><name xml:lang="en"><surname>Grjibovski</surname><given-names>Andrej M.</given-names></name><name xml:lang="ru"><surname>Гржибовский</surname><given-names>Андрей Мечиславович</given-names></name><name xml:lang="zh"><surname>Grjibovski</surname><given-names>Andrej M.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio><p>PhD</p></bio><email>a.grjibovski@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Almea</institution></aff><aff><institution xml:lang="ru">Алмеа</institution></aff><aff><institution xml:lang="zh">Almea</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Medical University REAVIZ</institution></aff><aff><institution xml:lang="ru">Медицинский университет «Реавиз»</institution></aff><aff><institution xml:lang="zh">Medical University REAVIZ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">University REAVIZ</institution></aff><aff><institution xml:lang="ru">Университет «Реавиз»</institution></aff><aff><institution xml:lang="zh">University REAVIZ</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-04-26" publication-format="electronic"><day>26</day><month>04</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2026</year></pub-date><volume>33</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>247</fpage><lpage>257</lpage><history><date date-type="received" iso-8601-date="2026-02-03"><day>03</day><month>02</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-04-03"><day>03</day><month>04</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/702109">https://hum-ecol.ru/1728-0869/article/view/702109</self-uri><abstract xml:lang="en"><p>The appearance of the skin and its appendages, including eyelashes and eyebrows, is an important component of physical and psychosocial well-being and substantially affects quality of life. The condition of eyelashes and eyebrows is determined by a complex interplay of endogenous and exogenous factors, including environmental exposure, systemic diseases, and cosmetic procedures. Interest has recently grown in cosmetic products aimed at stimulating growth and improving the quality of eyelashes and eyebrows; however, the evidence base supporting the effectiveness of many active ingredients remains limited. This narrative review summarizes current research on the potential of dihydroquercetin in combination with adenosine, kopyrrol, and several other compounds in cosmetic formulations intended to promote eyelash and eyebrow growth. We focus on the challenges of low solubility and bioavailability of dihydroquercetin and on current strategies for overcoming these limitations, including cyclodextrin encapsulation and other pharmaceutical and technological approaches. We present data on the molecular mechanisms underlying hair growth stimulation, including activation of the Wnt/β-catenin, AKT, and MAPK/CREB signaling pathways and induction of growth factors. We also review clinical and experimental studies evaluating adenosine, kopyrrol, arabinogalactan, and peptides for hair, eyebrow, and eyelash growth. Based on the analyzed data, we discuss the potential for synergistic effects of combined formulations, and outline key directions for further experimental and clinical research needed to substantiate the efficacy and safety of such cosmetic products in reducing the impact of adverse environmental factors and preserving aesthetic appearance, quality of life, satisfaction with appearance, and social functioning.</p></abstract><trans-abstract xml:lang="ru"><p>Внешний вид кожи и её придатков, включая ресницы и брови, является важным компонентом физического и психоэмоционального благополучия человека и существенно влияет на качество жизни. Состояние ресниц и бровей определяется сложным взаимодействием эндогенных и экзогенных факторов, включая воздействие окружающей среды, соматические заболевания и косметические процедуры. В последние годы отмечается особый интерес к косметическим средствам, направленным на стимуляцию роста и улучшение качества ресниц и бровей, однако доказательная база эффективности многих активных компонентов остаётся ограниченной. Настоящий нарративный обзор обобщает данные современной литературы, посвящённой потенциалу применения дигидрокверцетина в сочетании с аденозином, копирролом и рядом других веществ в составе косметических продуктов для роста ресниц и бровей. Особое внимание уделено проблемам низкой растворимости и биодоступности дигидрокверцетина и современным подходам к их преодолению, включая инкапсуляцию в циклодекстрины и использование других фармацевтико-технологических решений. Представлены данные о молекулярных механизмах, лежащих в основе стимуляции роста волос, включая активацию сигнальных путей Wnt/β-катенина, AKT, MAPK/CREB и индукцию факторов роста. Рассмотрены результаты клинических и экспериментальных исследований аденозина, копиррола, арабиногалактана и пептидов в отношении роста волос, бровей и ресниц. На основании проанализированных данных обсуждается возможность синергетического эффекта комбинированных составов, а также обозначаются ключевые направления для дальнейших экспериментальных и клинических исследований, необходимых для обоснования эффективности и безопасности подобных косметических средств для уменьшения воздействия неблагоприятных факторов внешней среды и сохранения эстетической привлекательности, качества жизни, удовлетворённости внешним видом и социального функционирования.</p></trans-abstract><trans-abstract xml:lang="zh"><p>皮肤及其附属物（包括睫毛和眉毛）的外观是人类身心安宁及生活质量的重要组成部分，并对其产生显著影响。睫毛和眉毛的状态由内源性和外源性因素（包括环境影响、躯体疾病及美容程序）的复杂相互作用决定。近年来，对旨在刺激生长和改善睫毛及眉毛质量的化妆品特别感兴趣，但许多活性成分的有效性证据基础仍然有限。本叙述性综述总结了当代文献数据，涉及二氢槲皮素与腺苷、可比罗尔及一系列其他物质在睫毛和眉毛生长化妆品配方中的应用潜力。特别关注二氢槲皮素低溶解性和生物利用度的问题及现代克服方法，包括环糊精包合技术和其他药物技术解决方案的应用。提供了关于刺激毛发生长的分子机制数据，包括Wnt/β-连环蛋白、AKT、MAPK/CREB信号通路的激活及生长因子的诱导。综述了腺苷、可比罗尔、阿拉伯半乳聚糖及多肽在毛发、眉毛和睫毛生长方面的临床与实验研究结果。基于分析数据讨论了复合配方的协同效应可能性，并指明了未来实验与临床研究的关键方向，这些研究对于论证此类减少外界不利因素影响、保持审美吸引力、生活质量、外貌满意度及社会功能的美容产品的有效性与安全性是必要的。</p></trans-abstract><kwd-group xml:lang="en"><kwd>dihydroquercetin</kwd><kwd>eyelashes</kwd><kwd>eyebrows</kwd><kwd>hair growth</kwd><kwd>cyclodextrins</kwd><kwd>bioavailability</kwd><kwd>adenosine</kwd><kwd>kopyrrol</kwd><kwd>cosmetic products</kwd><kwd>synergistic formulations</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дигидрокверцетин</kwd><kwd>ресницы</kwd><kwd>брови</kwd><kwd>рост волос</kwd><kwd>циклодекстрины</kwd><kwd>биодоступность</kwd><kwd>аденозин</kwd><kwd>копиррол</kwd><kwd>косметические средства</kwd><kwd>синергетические композиции</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>二氢槲皮素</kwd><kwd>睫毛</kwd><kwd>眉毛</kwd><kwd>毛发生长</kwd><kwd>环糊精</kwd><kwd>生物利用度</kwd><kwd>腺苷</kwd><kwd>可比罗尔</kwd><kwd>化妆品</kwd><kwd>协同配方</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">ООО «Эко-Вектор»</institution></institution-wrap><institution-wrap><institution xml:lang="en">Vector LLC</institution></institution-wrap><institution-wrap><institution xml:lang="zh">Vector LLC</institution></institution-wrap></funding-source><award-id>122</award-id></award-group><funding-statement xml:lang="en">The contribution of A.M. Grjibovski was supported under Agreement No. 122 with Eco-Vector LLC dated October 10, 2025.</funding-statement><funding-statement xml:lang="ru">Вклад А.М. Гржибовского реализован в рамках договора № 122 с ООО «Эко-Вектор» от 10.10.2025 г.</funding-statement><funding-statement xml:lang="zh">The contribution of A.M. Grjibovski was supported under Agreement No. 122 with Eco-Vector LLC dated October 10, 2025.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kowalewska B, Jankowiak B, Krajewska-Kułak E, et al. Quality of life in skin diseases as perceived by patients and nurses. Postepy Dermatol Alergol. 2021;37(6):956–961. doi: 10.5114/ada.2019.86182 EDN: KHFLKL</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kaya HE, Altunay İK, Aksu A. Perceived stress, stress coping strategies, and body image among facial dermatosis. 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