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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ekologiya cheloveka (Human Ecology)</journal-id><journal-title-group><journal-title xml:lang="en">Ekologiya cheloveka (Human Ecology)</journal-title><trans-title-group xml:lang="ru"><trans-title>Экология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1728-0869</issn><issn publication-format="electronic">2949-1444</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">703622</article-id><article-id pub-id-type="doi">10.17816/humeco703622</article-id><article-id pub-id-type="edn">BNGKFX</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDY ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Seasonal dynamics of endocrine parameters in young men and women in the Subarctic and their relationship with photoperiod and meteorological factors</article-title><trans-title-group xml:lang="ru"><trans-title>Сезонная динамика эндокринных показателей у молодых мужчин и женщин в Субарктике и их взаимосвязь с фотопериодом и метеорологическими факторами</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>亚亚北极地区青年男女性内分泌指标的季节性动态及其与光周期和气象因素的关联性</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3097-9427</contrib-id><contrib-id contrib-id-type="spin">2220-1377</contrib-id><name-alternatives><name xml:lang="en"><surname>Molodovskaya</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Молодовская</surname><given-names>Ирина Николаевна</given-names></name><name xml:lang="zh"><surname>Molodovskaya</surname><given-names>Irina N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology)</p></bio><bio xml:lang="ru"><p>канд. биол. наук</p></bio><bio xml:lang="zh"><p>Cand. Sci. (Biology)</p></bio><email>pushistiy-86@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6133-8249</contrib-id><contrib-id contrib-id-type="spin">4062-8845</contrib-id><name-alternatives><name xml:lang="en"><surname>Zyabisheva</surname><given-names>Valentina N.</given-names></name><name xml:lang="ru"><surname>Зябишева</surname><given-names>Валентина Николаевна</given-names></name><name xml:lang="zh"><surname>Zyabisheva</surname><given-names>Valentina N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>razvalush@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2097-3806</contrib-id><contrib-id contrib-id-type="spin">9490-2026</contrib-id><name-alternatives><name xml:lang="en"><surname>Tipisova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Типисова</surname><given-names>Елена Васильевна</given-names></name><name xml:lang="zh"><surname>Tipisova</surname><given-names>Elena V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Biology)</p></bio><bio xml:lang="ru"><p>д-р биол. наук</p></bio><bio xml:lang="zh"><p>Dr. Sci. (Biology)</p></bio><email>tipisova@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Research Center for Comprehensive Study of the Arctic n.a. acad. N.P. Laverov of the Ural Branch of the Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Федеральный исследовательский центр комплексного изучения Арктики им. акад. Н.П. Лаверова Уральского отделения Российской академии наук</institution></aff><aff><institution xml:lang="zh">Federal Research Center for Comprehensive Study of the Arctic n.a. acad. N.P. Laverov of the Ural Branch of the Russian Academy of Sciences</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-04-09" publication-format="electronic"><day>09</day><month>04</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2026</year></pub-date><volume>33</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>258</fpage><lpage>267</lpage><history><date date-type="received" iso-8601-date="2026-03-02"><day>02</day><month>03</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-03-17"><day>17</day><month>03</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hum-ecol.ru/1728-0869/article/view/703622">https://hum-ecol.ru/1728-0869/article/view/703622</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold><bold><italic> </italic></bold>Studying the hormonal profile of the same individuals under contrasting seasonal changes of climate and geophysical factors in Subarctic allows effective detection of periods of reduced adaptive capabilities of the endocrine system, which helps timely correct pre-pathological conditions.</p> <p><bold>AIM:</bold><bold><italic> </italic></bold>This work aimed to study the influence of seasonal dynamics of meteorological factors of the temperate-continental climate of Subarctic on serum levels of thyroid and sex hormones.</p> <p><bold>METHODS:</bold><bold><italic> </italic></bold>An analytical, prospective, uncontrolled study included 40 clinically healthy residents of Arkhangelsk (20 men and 20 women). Blood samples were collected quarterly for a year. Correlation between hormonal and climatic indicators was assessed using Spearman’s correlation coefficient.</p> <p><bold>RESULTS<italic>:</italic></bold><bold><italic> </italic></bold>In the examined men, statistically significant variability was detected in the levels of total fractions of iodothyronines, thyroxine-binding globulin, estradiol, and antisperm antibodies, correlating with climate factors. Levels of free iodothyronine fractions in men show a low amplitude in their annual rhythm and likely do not depend on seasonal factors. Conversely, in women, free fraction levels correlate positively with day length, whereas free thyroxine levels correlate negatively with air humidity. Overall, thyroid function parameters, regardless of sex, demonstrate a direct correlation with day length and air temperature, and an inverse correlation with atmospheric pressure and humidity. Unlike in women, circannual differences in estradiol and antisperm antibody levels were found in men, comparable to changes in photoperiod, fluctuations in atmospheric pressure, and air temperature.</p> <p><bold>CONCLUSION:<italic> </italic></bold>The findings indicate that the summer period with a long photoperiod is associated with increased activity of the pituitary–thyroid axis, whereas ovarian function does not show a significant dependence on day length.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Изучение гормонального профиля одних и тех же лиц в условиях контрастных сезонных изменений климатогеофизических факторов Субарктики позволяет эффективно выявлять периоды снижения адаптивных возможностей эндокринной системы, что поможет своевременно проводить коррекцию предпатологических состояний.</p> <p><bold>Цель</bold><bold><italic>.</italic></bold> Изучить влияние сезонной динамики метеорологических факторов умеренно-континентального климата Субарктики на сывороточные уровни тиреоидных и половых гормонов.</p> <p><bold>Методы.</bold> Проведено аналитическое проспективное неконтролируемое исследование с участием 40 клинически здоровых жителей Архангельска (20 мужчин и 20 женщин)<italic>.</italic> Образцы крови собирали каждые три месяца в течение года. Взаимосвязи между гормональными и климатическими показателями оценивали с помощью коэффициента корреляции Спирмена.</p> <p><bold>Результаты</bold><bold><italic>.</italic></bold> У обследованных мужчин выявлена статистически значимая вариабельность уровней общих фракций йодтиронинов, тироксинсвязывающего глобулина, эстрадиола и антиспермальных антител, коррелирующая с факторами климата. Уровни свободных фракций йодтиронинов у мужчин характеризуются незначительной величиной амплитуды круглогодичного ритма и, вероятно, не зависят от сезонных факторов. Напротив, у женщин содержание свободных фракций положительно коррелирует с длиной светового дня, а уровень свободного тироксина — отрицательно с влажностью воздуха. В целом показатели функции щитовидной железы независимо от пола демонстрируют прямую взаимосвязь с длиной светового дня и температурой воздуха и обратную — с атмосферным давлением и влажностью. У мужчин, в отличие от женщин, обнаружены цирканнуальные различия в уровнях эстрадиола и антиспермальных антител, сопоставимые с изменениями продолжительности светового дня, колебаниями атмосферного давления и температуры воздуха.</p> <p><bold>Заключение.</bold> Полученные данные свидетельствуют о том, что летний период с длинным фотопериодом ассоциирован с повышенной активностью гипофизарно-тиреоидной оси, в то время как функция яичников не проявляет значимой зависимости от продолжительности светового дня.</p></trans-abstract><trans-abstract xml:lang="zh"><p><bold>论证。</bold>通过对亚北极地区同一人群在显著季节性气候地球物理因素变化下激素水平的研究，可有效识别内分泌系统适应能力下降期，这有助于及时对亚临床病理状态进行干预调整。</p> <p>目的。研究亚北极地区温带大陆性气候的气象因素季节性动态对血清甲状腺激素和性激素水平的影响。</p> <p><bold>方法。</bold>一项针对40名阿尔汉格尔斯克市临床健康居民（20名男性，20名女性）的分析性前瞻性无对照研究已开展。血液样本按季度采集，持续一年。通过斯皮尔曼相关系数评估激素指标与气候参数之间的关联性。</p> <p><bold>结果。</bold>研究显示男性受试者的总碘甲状腺原氨酸、甲状腺素结合球蛋白、雌二醇和抗精子抗体水平存在与气候因素相关的统计学显著波动。男性游离碘甲状腺原氨酸水平的年节律振幅较小，可能与季节性因素无关。相反，女性游离碘甲状腺原氨酸含量与日照时长呈正相关， 而游离甲状腺素水平与空气湿度呈负相关。总体而言，无论性别，甲状腺功能指标均与日照时长和气温呈正相关，与大气压力和湿度呈负相关。与女性不同，男性雌二醇和抗精子抗体水平存在年周期性差异，这种变化与日照时长、气压波动和气温变化具有可比性。</p> <p><bold>结论。</bold>研究数据表明，夏季长光照期与垂体-甲状腺轴活性增强相关，而卵巢功能未见显著的光周期依赖性。</p></trans-abstract><kwd-group xml:lang="en"><kwd>sex hormones</kwd><kwd>thyroid hormones</kwd><kwd>circannual rhythm</kwd><kwd>climate</kwd><kwd>European North</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>половые гормоны</kwd><kwd>тиреоидные гормоны</kwd><kwd>цирканнуальный ритм</kwd><kwd>климат</kwd><kwd>Европейский север</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>性激素</kwd><kwd>甲状腺激素</kwd><kwd>年节律</kwd><kwd>气候</kwd><kwd>欧洲北部</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">ФНИР ФГБУН ФИЦКИА УрО РАН</institution></institution-wrap><institution-wrap><institution xml:lang="en">Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)</institution></institution-wrap><institution-wrap><institution xml:lang="zh">Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)</institution></institution-wrap></funding-source><award-id>125021902585-2</award-id></award-group><funding-statement xml:lang="en">The work was part of the Fundamental Research Program of Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS) (Reg. No. 125021902585-2) and used the equipment of the CT RF-Arctic Shared Research Facility (at FECIAR UrB RAS).</funding-statement><funding-statement xml:lang="ru">Работа выполнена в рамках программы ФНИР ФГБУН ФИЦКИА УрО РАН (номер гос. регистрации 125021902585-2) с использованием оборудования ЦКП КТ РФ-Арктика (ФИЦКИА УрО РАН).</funding-statement><funding-statement xml:lang="zh">The work was part of the Fundamental Research Program of Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS) (Reg. No. 125021902585-2) and used the equipment of the CT RF-Arctic Shared Research Facility (at FECIAR UrB RAS).</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Scott EM, Grant PJ. Neel revisited: the adipocyte, seasonality and type 2 diabetes. 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