Ekologiya cheloveka (Human Ecology)Ekologiya cheloveka (Human Ecology)Экология человека1728-08692949-1444Eco-Vector7146510.33396/1728-0869-2021-5-4-12ArticlesСтатьиResearch ArticleEPIGENETIC MARKERS OF THE INFLUENCE OF PARTICULATE MATTER WITH DIFFERENT AERODYNAMIC DIAMETERS ON HUMAN HEALTH: A REVIEWЭпигенетические маркеры воздействия твердых частиц с разным аэродинамическим диаметром на здоровье человека: обзор литературыTitovaA. G.ТитоваАнастасия Германовна

аналитик отдела анализа и прогнозирования медико-биологических рисков здоровью

titova@cspmz.ruZanyatkinI. A.ЗаняткинИ. А.VolkovaA. G.ВолковаА. Г.NechaevD. N.НечаевД. Н.TrusovG. A.ТрусовГ. А.Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological AgencyФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» Федерального медико-биологического агентства (ФГБУ «ЦСП» ФМБА России)15052021285NO5 (2021)№5 (2021)41210062021Copyright ©; 2021, Titova A.G., Zanyatkin I.A., Volkova A.G., Nechaev D.N., Trusov G.A.Copyright ©; 2021, Титова А.Г., Заняткин И.А., Волкова А.Г., Нечаев Д.Н., Трусов Г.А.2021Titova A.G., Zanyatkin I.A., Volkova A.G., Nechaev D.N., Trusov G.A.Титова А.Г., Заняткин И.А., Волкова А.Г., Нечаев Д.Н., Трусов Г.А.https://creativecommons.org/licenses/by-nc-nd/4.0https://hum-ecol.ru/1728-0869/article/view/71465

In this review article we provide an overview of epigenetic markers associated with the effects of particulate matter with different aerodynamic diameters, namely, PM0,1, PM, PM10 and PM2,5-10. The developed list of more than 150 epigenetic signatures of environmental pollutants on different human health conditions may contribute to the development of novel methodological approaches to early detection of diseases in individuals exposed to particulate matter. In addition, this work can become a prerequisite for the development of fundamentally new air purification systems.

Основной задачей представленной аналитической работы является описание и характеристика выявленных в ходе клинических исследований эпигенетических маркеров, ассоциированных с воздействием некоторых поллютантов на организм человека, а именно твердых частиц с разным аэродинамическим диаметром (PM , PM2,5, PM10, PM2,5-10), к которым сорбируются различные химические соединения. Целью проведенной работы было сформировать обобщенный перечень наиболее информативных биомаркеров, обнаруживаемых у человека. Практическая значимость созданного перечня из более чем полутора сотен эпигенетических сигнатур воздействия поллютантов на организм человека заключается в возможности разработки на его основе методологического подхода, который можно будет использовать для ранней диагностики заболеваний у людей, подвергшихся токсическому воздействию различных загрязнителей окружающей среды, в частности твердых частиц. Кроме того, данная работа может стать предпосылкой для разработки принципиально новых систем очистки воздуха.

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