Structural and functional changes in the arteries in young women living in the industrial region of the Far North under the aerogenic impact of chemical technogenic factors

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Abstract

Ambient air pollution is a significant risk factor for cardiovascular diseases.

Purpose of the work: to study the structural and functional characteristics of the carotid arteries in women living in the Far North under conditions of exposure to metals and particulate matter.

Materials and methods. Observation group consisted of seventy eight women living in the Far North in the zone of impact of metallurgical enterprises; comparison group included 20 women living in similar climatic conditions. Duplex scanning of the brachiocephalic arteries was used to evaluate the intima-media thickness (IMT), Peterson’s (Ep) and Young’s (Ym) elastic modules. The cause-and-effect relationships of vascular disorders with blood concentrations of nickel, copper, and chromium were studied.

Results. In the observation group the IMT thickness was greater than in the comparison group (0.55 (0.49;0.62) mm versus 0.46 (0.45;0.5) mm, p < 0.0001). In the observation group, Ep was 1.84 times and Ym was 1.52 times higher than the indicators in the comparison group. The relative risk of increasing IMT reached 2.1 (95% CI 1.1–4.3). An increase in the probability of IMT thickening was revealed with an increase in the blood chromium concentration (R2 = 0.10; p = 0.003), an increase in the values of Ep — copper (R2 = 0.15; p = 0.002) and chromium (R2 = 0.19; p = 0.0002), and Ym values — copper (R2 = 0.39; p < 0.0001).

Limitations of the study. This study did not include middle-aged and elderly women, men, and did not include the population of territories other than the Far North.

Conclusions. Young women living in conditions of inhalation exposure to nickel, chromium, copper, and particulate matter experience an intensification of atherosclerotic and arteriosclerotic processes, manifested by an increase in IMT, atherosclerotic plaques, and an increase in the stiffness of the common carotid artery (CCA). A cause-and-effect relationship between the copper and chromium blood concentration and the probability of an increase in IMT, Ep and Ym has been established. The identified changes in the CCA make it possible to classify young women living in environmentally unfavourable areas as a higher category of cardiovascular risk.

Compliance with ethical standards. The study program was approved by the ethics committee of the FBSI «Federal scientific center for medical and preventive health risk management technologies» (protocol No. 3 dated January 26, 2022). All patients were informed about the purpose of the study, and voluntary informed consent was obtained.

Contribution of the authors:
Nosov A.E. — collection of material, statistical processing, text writing;
Ustinova O.Yu. — concept, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of its final version.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: August 22, 2023
Accepted: October 11, 2023
Published: December 23, 2023

About the authors

Alexander E. Nosov

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Author for correspondence.
Email: nosov@fcrisk.ru
ORCID iD: 0000-0003-0539-569X

MD, PhD, Head of the Department of Radiation and Functional Diagnostics, Federal scientific center for medical and preventive health risk management technologies, Perm, 614045, Russian Federation.

e-mail: nosov@fcrisk.ru

Russian Federation

Olga Yu. Ustinova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; Perm State National Research University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9916-5491
Russian Federation

References

  1. Rajagopalan S., Al-Kindi S.G., Brook R.D. Air pollution and cardiovascular disease: JACC state-of-the-art review. J. Am. Coll. Cardiol. 2018; 72(17): 2054–70. https://doi.org/10.1016/j.jacc.2018.07.099
  2. Edlund K.K., Sallsten G., Molnár P., Andersson E.M., Ögren M., Segersson D., et al. Long-term exposure to air pollution, coronary artery calcification, and carotid artery plaques in the population-based Swedish SCAPIS Gothenburg cohort. Environ. Res. 2022; 214(Pt. 2): 113926. https://doi.org/10.1016/j.envres.2022.113926
  3. Al-Kindi S.G., Brook R.D., Biswal S., Rajagopalan S. Environmental determinants of cardiovascular disease: lessons learned from air pollution. Nat. Rev. Cardiol. 2020; 17(10): 656–72. https://doi.org/10.1038/s41569-020-0371-2
  4. Münzel T., Sørensen M., Gori T., Schmidt F.P., Rao X., Brook J., et al. Environmental stressors and cardio-metabolic disease: part I-epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies. Eur. Heart J. 2017; 38(8): 550–6. https://doi.org/10.1093/eurheartj/ehw269
  5. Münzel T., Sørensen M., Gori T., Schmidt F.P., Rao X., Brook J., et al. Environmental stressors and cardio-metabolic disease: part II – mechanistic insights. Eur. Heart J. 2017; 38(8): 557–64. https://doi.org/10.1093/eurheartj/ehw294
  6. Münzel T., Gori Т., Al-Kindi S., Deanfield J., Lelieveld L., Daiber A., et al. Effects of gaseous and solid constituents of air pollution on endothelial function. Eur. Heart J. 2018; 39(38): 3543–50. https://doi.org/10.1093/eurheartj/ehy481
  7. Kelly F.J., Fussell J.C. Air pollution and public health: emerging hazards and improved understanding of risk. Environ. Geochem. Health. 2015; 37(4): 631–49. https://doi.org/10.1007/s10653-015-9720-1
  8. May I.V., Kleyn S.V., Balashov S.Yu., Vekovshinina S.A., Markovich N.I. Experience of substantiation and results of monitoring of priority air pollutants in Norilsk within the Federal Clean Air Project. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2022; 30(12): 45–52. https://doi.org/10.35627/2219-5238/2022-30-12-45-52 https://elibrary.ru/mkzzzq (in Russian)
  9. Touboul P.J., Hennerici M.G., Meairs S., Adams H., Amarenco P., Bornstein N., et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc. Dis. 2012; 34(4): 290–6. https://doi.org/10.1159/000343145
  10. Cohen A.J., Brauer M., Burnett R., Anderson H.R., Frostad J., Estep K., et al. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet. 2017; 389(10082): 1907–18. https://doi.org/10.1016/S0140-6736(17)30505-6
  11. Langrish J.P., Fuller R., Acosta N.J.R., Adeyi O., Arnold R., Basu N.N., et al. The Lancet Commission on pollution and health. Lancet. 2018; 391(10119): 462–512. https://doi.org/10.1016/S0140-6736(17)32345-0
  12. Langrish J.P., Unosson J., Bosson J., Barath S., Muala A., Blackwell S., et al. Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. J. Am. Heart Assoc. 2013; 2(1): e004309. https://doi.org/10.1161/JAHA.112.004309
  13. Byrd J.B., Morishita M., Bard R.L., Das R., Wang L., Sun Z., et al. Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location. J. Am. Soc. Hypertens. 2016; 10(2): 133–9.e4. https://doi.org/10.1016/j.jash.2015.11.015
  14. Kaufman J.D., Adar S.D., Barr R.G., Budoff M., Burke J.L., Curl C.L., et al. Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study. Lancet. 2016; 388(10045): 696–704. https://doi.org/10.1016/S0140-6736(16)00378-0
  15. Wang F., Jia X., Wang X., Zhao Y., Hao W. Particulate matter and atherosclerosis: a bibliometric analysis of original research articles published in 1973–2014. BMC Public Health. 2016; 16: 348. https://doi.org/10.1186/s12889-016-3015-z
  16. Provost E.B., Madhloum N., Panis L.I., De Boever P., Nawrot T.S. Carotid intima-media thickness, a marker of subclinical atherosclerosis, and particulate air pollution exposure: the meta-analytical evidence. PLoS One. 2015; 10(5): e0127014. https://doi.org/10.1371/journal.pone.0127014
  17. Zanoli L., Lentini P., Granata F., Gaudio A., Fatuzzo P., Serafino L., et al. A systematic review of arterial stiffness, wave reflection and air pollution. Mol. Med. Rep. 2017; 15(5): 3425–9. https://doi.org/10.3892/mmr.2017.6392
  18. Chowdhury R., Ramond A., O’Keeffe L.M., Shahzad S., Kunutsor S.K., Muka T., et al. Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2018; 362: k3310. https://doi.org/10.1136/bmj.k3310
  19. Kang Y.J. Copper and homocysteine in cardiovascular diseases. Pharmacol. Ther. 2011; 129(3): 321–31. https://doi.org/10.1016/j.pharmthera.2010.11.004
  20. Mamyrbaev A.A. Toxicology of Chromium and Its Compounds [Toksikologiya khroma i ego soedineniy]. Aktobe; 2012. (in Russian)
  21. Yakovlev N.A. Psychophysiological studies in the early diagnosis of changes in the nervous system when exposed to chromium compounds on the body. Gigiena truda i profzabolevaniya. 1982; (7): 33–6. (in Russian)
  22. Balali-Mood M., Naseri K., Tahergorabi Z., Khazdair M.R., Sadeghi M. Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic. Front. Pharmacol. 2021; 12: 643972. https://doi.org/ 10.3389/fphar.2021.643972
  23. Lippmann M., Ito K., Hwang J.S., Maciejczyk P., Chen L.C. Cardiovascular effects of nickel in ambient air. Environ. Health Perspect. 2006; 114(11): 1662–9. https://doi.org/10.1289/ehp.9150
  24. Navas-Acien A., Martinez-Morata I., Hilpert M., Rule A., Shimbo D., LoIacono N.J. Early cardiovascular risk in E-cigarette users: the potential role of metals. Curr. Environ. Health Rep. 2020; 7(4): 353–61. https://doi.org/10.1007/s40572-020-00297-y
  25. Lamas G.A., Navas-Acien A., Mark D.B., Lee K.L. Heavy metals, cardiovascular disease, and the unexpected benefits of chelation therapy. J. Am. Coll. Cardiol. 2016; 67(20): 2411–8. https://doi.org/10.1016/j.jacc.2016.02.066

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