Changes in mortality, life expectancy and the rate of aging in the XX century: possible causes

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Introduction. The rapid aging of the world and Russian population and the associated medical, demographic, and socioeconomic problems determine the increased interest in the issue of aging. 

Aim and objectives. to study the features and causes of changes in age-related mortality, life expectancy (LE), and aging in Russia in the second half of the XX century compared to other countries. 

Material and methods. We used the Human Mortality Database survival tables to estimate the expected and maximum life expectancy. The aging rate was calculated using the Gompertz–Makeham formula and the increment of total mortality. Graphs were built using Microsoft Office Excel’s standard tools and the computer program Aging of Populations developed by us. 

Results. Until the middle of the XX century, significant aging rate changes did not accompany a sharp increase in Le. Later with a relatively small increase in LE, it decreases sharply. Deceleration of aging was observed for all studied countries (from 12 to 36 for different available historical periods) for all studied parameters and progresses to the end of the studied period. For Russia, the decline in the aging rate that began simultaneously 7 with other countries in 1960–1970's slows down and is restored only by 2000. 

Discussion. Improvements in living conditions and health outcomes lead to an increase in the proportion of the elderly population structure. However, these same processes reduce the rate of individual aging. Improving medical and social care for retired people reduces their mortality rate. Still, it produces a phenomenon of delayed mortality in later ages (the phenomenon of inversion of centenarians’ total mortality – from reduced to increased). Nevertheless, the use of the mortality rate increment indicator shows that the decline in the aging rate for centenarians persists. 

Conclusion. The identified trends in mortality are useful for developing areas of preventive and socio-medical impact on the population’s health.

作者简介

Vitaly Dontsov

Federal Research Center «Computer Science and Control»

编辑信件的主要联系方式.
Email: dontsovvi@mail.ru
ORCID iD: 0000-0002-2234-4715

MD, lead researcher of the Department 102 of Institute for Systems Analysis, Federal Research Center “Computer Science and Control” of Russian Academy of Sciences. Moscow, 117312, Russian Federation.

e-mail: dontsovvi@mail.ru

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参考

  1. Il’icheva Yu.V., Kolotova S.A. The impact of demographic processes on the productivity of social labor. Upravlenie personalom i intellektual’nymi resursami v Rossii. 2014; 3(3): 49–54. https://doi.org/10.12737/4879 (in Russian)
  2. Smirnova T.M., Krut’ko V.N. Historical dynamics of mortality and its accounting for strategic planning of medical and social assistance for the elderly. Klinicheskaya gerontologiya. 2018; 24(9-10): 63–5. (in Russian)
  3. Brown N.J.L., Albers C.J., Ritchie S.J. Contesting the evidence for limited human lifespan. Nature. 2017; 546(7660): E6-E7. https://doi.org/10.1038/nature2278
  4. Dong X., Milholland B., Vijg J. Evidence for a limit to human lifespan. Nature. 2016; 538(7624): 257–9. https://doi.org/10.1038/nature19793
  5. Lenart A., Vaupel J.W. Questionable evidence for a limit to human lifespan. Nature. 2017; 546(7660): E13-E4. https://doi.org/10.1038/nature22790
  6. Skiadas C.H. Remarks on «Limits to Human Lifespan». In: Skiadas C., Skiadas C., eds. Demography and Health Issues. The Springer Series on Demographic Methods and Population Analysis. Volume 46. Cham: Springer; 2018; 46: 15–30. https://doi.org/10.1007/978-3-319-76002-5_2
  7. De Beer J., Bardoutsos A., Janssen F. Maximum human lifespan may increase to 125 years. Nature. 2017; 546(7670): E16-E7. https://doi.org/10.1038/nature22792
  8. Gavrilov L.A., Krut’ko V.N., Gavrilova N.S. The future of human longevity. Gerontology. 2017; 63(6): 524–6. https://doi.org/10.1159/000477965
  9. Kinsella K.G. Future longevity-demographic concerns and consequences. J. Am. Geriatr. Soc. 2005; 53(9 Suppl.): 299–303. https://doi.org/10.1111/j.1532-5415.2005.53494.x
  10. Zuo W., Jiang S., Guo Z., Feldman M.W., Tuljapurkar S. Advancing front of old-age human survival. PNAS. 2018; 115(44): 11209–14. https://doi.org/10.1073/pnas.1812337115
  11. Barbi E., Lagona F., Marsili M., Vaupel J.W., Wachter K.W. The plateau of human mortality: Demography of longevity pioneers. Science. 2018; 360(6396): 1459–61. https://doi.org/10.1126/science.aat3119
  12. Gavrilov L.A., Gavrilova N.S., Krut’ko V.N. New evidence that protective effects of familial longevity expire at older ages. Theses of the IAGG 2017 World Congress (July 23-27, 2017). San Francisco, California. Innov. Aging. 2017; 1(Suppl. 1): 896. https://doi.org/10.1093/geroni/igx004.3215
  13. Griffin R.M., Hayward A.D., Bolund E., Maklakov A.A., Lummaa V. Sex differences in adult mortality rate mediated by early life environmental conditions. Ecol. Lett. 2018; 21(2): 235–42. https://doi.org/10.1111/ele.12888
  14. Finch C.E. Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. PNAS. 2010; 107(1): 1718–24. https://doi.org/10.1073/pnas.0909606106
  15. Ribeiro A.I., Krainski E.T., Carvalho M.S., De Fátima de Pina M. The influence of socioeconomic deprivation, access to healthcare and physical environment on old-age survival in Portugal. Geospat. Health. 2017; 12(2): 581. https://doi.org/10.4081/gh.2017.581
  16. Canudas-Romo V., Mazzuco S., Zanotto L. Measures and Mo-dels of Mortality. In: Handbook of Statistics. Volume 39. Elseveir; 2018: 405–42. https://doi.org/10.1016/bs.host.2018.05.002
  17. Dontsov V.I. Changes of mortality and rate of aging in the second half of 20th century in Russia. Zdravookhranenie Rossiyskoy Federatsii. 2019; 63(1): 42–7. https://doi.org/10.18821/0044-197Kh-2019-63-1-42-47 (in Russian)
  18. The Human Mortality Database. Available at: http://www.mortality.org
  19. Gavrilov L.A., Gavrilova N.S. The Biology of Life Span: A Quantitative Approach. New York: Harwood Academic Publisher; 1991.
  20. Gompertz B. On the nature of the function expressive of the law of human mortality, and on the mode of determining the value of life contingencies. Philos. Trans. R. Soc. Lond. A. 1825; 115: 513–85. https://doi.org/10.1098/rstl.1825.0026
  21. Cha J., Finkelstein M. On some mortality rate processes and mortality deceleration with age. J. Math. Biol. 2016; 72(1-2): 331–42. https://doi.org/10.1007/s00285-015-0885-0
  22. Yashin A.I., Ukraintseva S.V., De Benedictis G., Anisimov V.N., Butov A.A., Arbeev K., et al. Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. J. Gerontol. A Biol. Sci. Med. Sci. 2001; 56(10): B432–42.
  23. Kirkwood T.B. Deciphering death: a commentary on Gompertz (1825) ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies’. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2015; 370(1666): 20140379. https://doi.org/10.1098/rstb.2014.0379
  24. Olshansky S.J., Carnes B.A. Ever since Gompertz. Demography. 1997; 34(1): 1–15.
  25. Dontsov V.I., Krut’ko V.N. Aging: a system approach. Trudy Instituta sistemnogo analiza Rossiyskoy akademii nauk. 2017; 67(1): 104–12. (in Russian)
  26. Dontsov V.I. General System Theory of Aging. Special Role of the Immune System. Ridero; 2019.
  27. Kreiner C.T., Nielsen T.H., Serena B.L. Role of income mobility for the measurement of inequality in life expectancy. Proc. Natl. Acad. Sci. USA. 2018; 115(46): 11754–9. https://doi.org/10.1073/pnas.1811455115
  28. Waldron H. Trends in mortality differentials and life expectancy for male social security-covered workers, by socioeconomic status. Soc. Secur. Bull. 2007; 67(3): 1–28.
  29. Khasanova R. Mortality rate in Russia: what do the 2017 data mean? Ekonomicheskoe razvitie Rossii. 2018; 25(2): 64–8. (in Russian)
  30. Krut’ko V.N., Smirnova TM Analysis of Trends in Mortality and Life Expectancy of the Russian Population at the End of the XX Century [Analiz tendentsiy smertnosti i prodolzhitel’nosti zhizni naseleniya Rossii v kontse XX veka]. Moscow: URSS; 2002. (in Russian)
  31. Dato S., Rose G., Crocco P., Monti D., Garagnani P., Franceschi C., et al. The genetics of human longevity: an intricacy of genes, environment, culture and microbiome. Mech. Ageing Dev. 2017; 165(Pt. B): 147–55. https://doi.org/10.1016/j.mad.2017.03.011
  32. Hayflick L. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PLoS Genet. 2007; 3(12): e220. https://doi.org/10.1371/journal.pgen.0030220
  33. Rossolini G., Piantanelli L. Mathematical modeling of the aging processes and the mechanisms of mortality: paramount role of heterogeneity. Exp. Gerontol. 2001; 36(8): 1277–88.
  34. Krut’ko V.N., Dontsov V.I., Khalyavkin A.V., Markova A.N. Natural aging as a sequential poly-systemic syndrome. Front. Biosci. (Landmark Ed.) 2018; 23: 909–20. https://doi.org/10.2741/4624

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