Enviar artigo por via de e-mail The Sintesis and Antioxidant Activity of New bis-1,3,4-Oxadiazoles, bis-1,3,4-Thiadiazoles, and Their Derivatives
- Autores: Dilanyan S.V.1, Buniatyan Z.M.1, Panosyan H.A.1
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Afiliações:
- The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
- Edição: Volume 60, Nº 10 (2024)
- Páginas: 1030-1035
- Seção: Articles
- URL: https://hum-ecol.ru/0514-7492/article/view/682484
- DOI: https://doi.org/10.31857/S0514749224100047
- EDN: https://elibrary.ru/QMNPJZ
- ID: 682484
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Resumo
Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of lipid oxidation in the form of a decrease in the amount of MDA.
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Sobre autores
S. Dilanyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Autor responsável pela correspondência
Email: nana_dilanyan@mail.ru
ORCID ID: 0000-0003-1786-5548
Armênia, prosp. Azatutyan, 26, Yerevan, 0014
Zh. Buniatyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: nana_dilanyan@mail.ru
ORCID ID: 0000-0002-3152-3176
Armênia, prosp. Azatutyan, 26, Yerevan, 0014
H. Panosyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: nana_dilanyan@mail.ru
ORCID ID: 0000-0001-8311-6276
Armênia, prosp. Azatutyan, 26, Yerevan, 0014
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