Targeting Cervical Cancer Stem Cells by Phytochemicals


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Abstract

:Cervical cancer (CaCx) poses a significant global health challenge, ranking as the fourth most common cancer among women worldwide. Despite the emergence of advanced treatment strategies, recurrence remains a bottleneck in favorable treatment outcomes and contributes to poor prognosis. The chemo- or radio-therapy resistance coupled with frequent relapse of more aggressive tumors are some key components that contribute to CaCx-related mortality. The onset of therapy resistance and relapse are attributed to a small subset of, slow-proliferating Cancer Stem Cells (CSC). These CSCs possess the properties of tumorigenesis, self-renewal, and multi-lineage differentiation potential. Because of slow cycling, these cells maintain themselves in a semi-quiescent stage and protect themselves from different anti-proliferative anti-cancer drugs. Keeping in view recent advances in their phenotypic and functional characterization, the feasibility of targeting CSC and associated stem cell signaling bears a strong translational value. The presence of CSC has been reported in CaCx (CCSC) which remains a forefront area of research. However, we have yet to identify clinically useful leads that can target CCSC. There is compelling evidence that phytochemicals, because of their advantages over synthetic anticancer drugs, could emerge as potential therapeutic leads to target these CCSCs. The present article examined the potential of phytochemicals with reported anti-CSC properties and evaluated their future in preclinical and clinical applications against CaCx.

About the authors

Tanya Tripathi

Molecular Oncology Laboratory, Department of Zoology,, University of Delhi (North Campus)

Email: info@benthamscience.net

Joni Yadav

Molecular Oncology Laboratory, Department of Zoology,, University of Delhi (North Campus)

Email: info@benthamscience.net

Divya Janjua

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Apoorva Chaudhary

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Udit Joshi

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Anna Senrung

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Arun Chhokar

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Nikita Aggarwal

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Email: info@benthamscience.net

Alok Chandra Bharti

Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus)

Author for correspondence.
Email: info@benthamscience.net

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