Radiotherapy-associated Sensorineural Hearing Loss in Pediatric Oncology Patients

  • Authors: Aslam M.1, Ahmad H.2, Malik H.2, Uinarni H.3, Karim Y.4, Akhmedov Y.5, Abdelbasset W.6, Awadh S.7, Abid M.8, Mustafa Y.9, Farhood B.10, Sahebkar A.11
  • Affiliations:
    1. Department of Emergency Medicine, Rawalpindi Medical University
    2. Department of Medicine, Rawalpindi Medical University
    3. Department of Anatomy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia,
    4. Al-Nisour University College, Al-Manara College for Medical Sciences
    5. Department of Pediatric Surgery, Samarkand State Medical Institute
    6. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University
    7. Department of Anesthesia, Al-Mustaqbal University
    8. Department of Anesthesia, College of Health & medical Technology, Al-Ayen University
    9. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul
    10. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences
    11. Biotechnology Research Center, Pharmaceutical Technology Institute,, Mashhad University of Medical Sciences
  • Issue: Vol 31, No 33 (2024)
  • Pages: 5351-5369
  • Section: Anti-Infectives and Infectious Diseases
  • URL: https://hum-ecol.ru/0929-8673/article/view/645052
  • DOI: https://doi.org/10.2174/0929867330666230515112245
  • ID: 645052

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Full Text

Abstract

:During the radiotherapeutic treatment of pediatric oncology patients, they would be at a latent risk of developing ionizing radiation-induced ototoxicity when the cochlea or auditory nerve is located within the radiation field. Sensorineural hearing loss (SNHL) is an irreversible late complication of radiotherapy, and its incidence depends on various factors such as the patient’s hearing sensitivity, total radiation dose to the cochlea, radiotherapy fractionation regimen, age and chemoradiation. Importantly, this complication exhibits serious challenges to adult survivors of childhood cancer, as it has been linked to impairments in academic achievement, psychosocial development, independent living skills, and employment in the survivor population. Therefore, early detection and proper management can alleviate academic, speech, language, social, and psychological morbidity arising from hearing deficits. In the present review, we have addressed issues such as underlying mechanisms of radiation-induced SNHL, audiometric findings of pediatric cancer patients treated with radiotherapy, and management and protection measures against radiation-induced ototoxicity.

About the authors

Muhammad Aslam

Department of Emergency Medicine, Rawalpindi Medical University

Email: info@benthamscience.net

Hassaan Ahmad

Department of Medicine, Rawalpindi Medical University

Email: info@benthamscience.net

Hamza Malik

Department of Medicine, Rawalpindi Medical University

Email: info@benthamscience.net

Herlina Uinarni

Department of Anatomy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia,

Email: info@benthamscience.net

Yasir Karim

Al-Nisour University College, Al-Manara College for Medical Sciences

Email: info@benthamscience.net

Yusuf Akhmedov

Department of Pediatric Surgery, Samarkand State Medical Institute

Email: info@benthamscience.net

Walid Abdelbasset

Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University

Email: info@benthamscience.net

Sura Awadh

Department of Anesthesia, Al-Mustaqbal University

Email: info@benthamscience.net

Mohammed Abid

Department of Anesthesia, College of Health & medical Technology, Al-Ayen University

Email: info@benthamscience.net

Yasser Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul

Email: info@benthamscience.net

Bagher Farhood

Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Amirhosein Sahebkar

Biotechnology Research Center, Pharmaceutical Technology Institute,, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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