Mechanisms of the Quorum Sensing Systems of Pseudomonas aeruginosa: Host and Bacteria


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Abstract

:Quorum-sensing is a communication mechanism between bacteria with the ability to activate signaling pathways in the bacterium and in the host cells. Pseudomonas aeruginosa is a pathogen with high clinical relevance due to its vast virulence factors repertory and wide antibiotic resistance mechanisms. Due to this, it has become a pathogen of interest for developing new antimicrobial agents in recent years. P. aeruginosa has three major QS systems that regulate a wide gene range linked with virulence factors, metabolic regulation, and environment adaption. Consequently, inhibiting this communication mechanism would be a strategy to prevent the pathologic progression of the infections caused by this bacterium. In this review, we aim to overview the current studies about the signaling mechanisms of the QS system of P. aeruginosa and its effects on this bacterium and the host.

About the authors

Diana Flores-Percino

Department of Medicine, Benemérita Universidad Autónoma de Puebla

Email: info@benthamscience.net

Estefanie Osorio-Llanes

Department of Microbiology, Faculty of Exact and Natural Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Barranquilla

Email: info@benthamscience.net

Yanireth Sepulveda

Department of Microbiology, Faculty of Exact and Natural Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Barranquilla

Email: info@benthamscience.net

Jairo Castellar- López

Department of Microbiology, Faculty of Exact and Natural Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Barranquilla

Email: info@benthamscience.net

Ricardo Madera

Department of Medicine, Faculty of Health Science, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Seccional Barranquilla

Email: info@benthamscience.net

Wendy Rada

Department of Microbiology, Faculty of Exact and Natural Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Barranquilla

Email: info@benthamscience.net

Carlos Meléndez

Department of Chemistry, Faculty of Basic Sciencies, Grupo de Investigación en Química Orgánica y Biomédica, Universidad del Atlántico

Email: info@benthamscience.net

Evelyn Mendoza-Torres

Department of Medicine, Faculty of Health Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Seccional Barranquilla

Author for correspondence.
Email: info@benthamscience.net

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