The Mechanisms of miRNAs on Target Regulation and their Recent Advances in Atherosclerosis


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Abstract

:miRNAs are crucial regulators in a variety of physiological and pathological processes, while their regulation mechanisms were usually described as negatively regulating gene expression by targeting the 3’-untranslated region(3’-UTR) of target gene miRNAs through seed sequence in tremendous studies. However, recent evidence indicated the existence of non-canonical mechanisms mediated by binding other molecules besides mRNAs. Additionally, accumulating evidence showed that functions of intracellular and intercellular miRNAs exhibited spatiotemporal patterns. Considering that detailed knowledge of the miRNA regulating mechanism is essential for understanding the roles and further clinical applications associated with their dysfunction and dysregulation, which is complicated and not fully clarified. Based on that, we summarized the recently reported regulation mechanisms of miRNAs, including recognitions, patterns of actions, and chemical modifications. And we also highlight the novel findings of miRNAs in atherosclerosis progression researches to provide new insights for non-coding RNA-based therapy in intractable diseases.

About the authors

Runting Yin

School of Pharmacy, Jiangsu University

Author for correspondence.
Email: info@benthamscience.net

Hongyu Lu

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Yixin Cao

Department of Medical Oncology, Affiliated Hospital of Jiangsu University

Email: info@benthamscience.net

Jia Zhang

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Geng Liu

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Qian Guo

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Xinyu Kai

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Jiemin Zhao

School of Pharmacy, Jiangsu University

Email: info@benthamscience.net

Yuan Wei

School of Pharmacy, Jiangsu University

Author for correspondence.
Email: info@benthamscience.net

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