Research Progress of Pyroptosis in Renal Diseases

  • Authors: Hu B.1, Ma K.2, Wang W.3, Han Z.4, Chi M.5, Nasser M.I.6, Liu C.3
  • Affiliations:
    1. School of Medicine, University of Electronic Science and Technology of China
    2. Department of Nephrology, Osaka University Graduate School of Medicine
    3. Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China,
    4. School of Medical and Life Sciences, Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine
    5. Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China
    6. Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital,, Guangdong Academy of Medical Sciences
  • Issue: Vol 31, No 40 (2024)
  • Pages: 6656-6671
  • Section: Anti-Infectives and Infectious Diseases
  • URL: https://hum-ecol.ru/0929-8673/article/view/645132
  • DOI: https://doi.org/10.2174/0109298673255656231003111621
  • ID: 645132

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Abstract

:Kidney diseases, particularly Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD), are identified as global public health issues affecting millions of individuals. In addition, the frequency of renal diseases in the population has increased dramatically and rapidly in recent years. Renal disorders have become a significant public health burden. The pathophysiology of renal diseases is significantly connected with renal cell death, including apoptosis, necrosis, necroptosis, ferroptosis, pyroptosis, and autophagy, as is now recognized. Unlike other forms of cell death, pyroptosis is a unique planned cell death (PCD). Scientists have proven that pyroptosis is crucial in developing various disorders, and this phenomenon is gaining increasing attention. It is considered a novel method of inflammatory cell death. Intriguingly, inflammation is among the most significant pathological characteristics of renal disease. This study investigates the effects of pyroptosis on Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), Diabetic Nephropathy (DN), Immunoglobulin A (IgA) Nephropathy, and Lupus Nephritis (LN) to identify novel therapeutic targets for kidney diseases.

About the authors

Boyan Hu

School of Medicine, University of Electronic Science and Technology of China

Email: info@benthamscience.net

Kuai Ma

Department of Nephrology, Osaka University Graduate School of Medicine

Email: info@benthamscience.net

Wei Wang

Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China,

Email: info@benthamscience.net

Zhongyu Han

School of Medical and Life Sciences, Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine

Email: info@benthamscience.net

Mingxuan Chi

Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China

Email: info@benthamscience.net

Moussa Ide Nasser

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital,, Guangdong Academy of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Chi Liu

Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China,

Author for correspondence.
Email: info@benthamscience.net

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