Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?


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Abstract

Background:Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti- inflammatory properties and potential therapeutic applications.

Objectives:This narrative review explores the potential utility of CAPE in cancer treatment.

Methods:We comprehensively reviewed relevant studies from scientific databases (PubMed and Web of Science) from 2000 to 2022. Our search focused on keywords such as cancer, natural drugs, caffeic acid phenethyl ester, CAPE, cancer cell lines, antitumor effects, and propolis.

Results:CAPE exhibits diverse biological benefits, including antimicrobial, antioxidant, antiviral, anti-inflammatory, cytotoxic, and potentially anti-carcinogenic properties. Numerous studies have demonstrated its wide-ranging antitumor effects on various cancer cell lines, including growth inhibition, apoptosis induction, tumor invasiveness prevention, malignancy suppression, and anti-angiogenic activity.

Conclusion:Following comprehensive preclinical toxicity assessments, further evaluation of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate its potential health benefits in diverse forms of human cancer.

About the authors

Geir Bjørklund

CONEM, Council for Nutritional and Environmental Medicine

Author for correspondence.
Email: info@benthamscience.net

Olha Storchylo

Medical Chemistry Department, Odessa National Medical University

Email: info@benthamscience.net

Massimiliano Peana

Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari

Email: info@benthamscience.net

Tony Hangan

Faculty of Medicine, Ovidius University of Constanta

Author for correspondence.
Email: info@benthamscience.net

Roman Lysiuk

Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Larysa Lenchyk

Department of Chemistry of Natural Compounds, National University of Pharmacy

Email: info@benthamscience.net

Oleh Koshovyi

CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy

Email: info@benthamscience.net

Halyna Antonyak

Department of Ecology, Ivan Franko National University of Lviv

Email: info@benthamscience.net

Nataliia Hudz

Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University

Email: info@benthamscience.net

Salvatore Chirumbolo

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona

Email: info@benthamscience.net

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