MicroRNA Profiles in Critically Ill Patients


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Abstract

:The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological processes. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision-- making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients.

About the authors

Babak Alikiaii

Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences

Email: info@benthamscience.net

Mohammad Bagherniya

Nutrition and Food Security Research Center, Isfahan University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Gholamreza Askari

Nutrition and Food Security Research Center, Isfahan University of Medical Sciences

Email: info@benthamscience.net

Rajkumar Rajendram

Department of Medicine, King Abdulaziz Medical City, King Abdulaziz International Medical Research Center, Ministry of National Guard - Health Affairs

Email: info@benthamscience.net

Amirhossein Sahebkar

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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