Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels


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Background:Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications.

Objective:Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method.

Methods:The composition and structural features of the hydrogel were studied using a complex of modern analytical techniques, including TEM, XRD, and AES. On the example of experimental animals hemostatic activity of the hydrogel was studied, as well as primary toxicological studies were carried out.

Results:The composition of dispersed phase and dispersion medium of silicon‒iron glycerolates hydrogel was determined. The structural features of hydrogel were revealed and its structure model was proposed. It was shown that silcon-iron glycerolates hydrogel is nontoxic, and exhibits pronounced hemostatic activity.

Conclusion:Silicon-iron glycerolates hydrogel is a potential hemostatic agent for topical application in medical and veterinary practice.

作者简介

Tat’yana Khonina

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: info@benthamscience.net

Denis Tishin

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: info@benthamscience.net

Leonid Larionov

, Ural State Medical University

Email: info@benthamscience.net

Artur Osipenko

, Ural State Medical University

Email: info@benthamscience.net

Maria Dobrinskaya

, Ural State Medical University

Email: info@benthamscience.net

Ekaterina Bogdanova

Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences

Email: info@benthamscience.net

Maxim Karabanalov

, Ural Federal University

Email: info@benthamscience.net

Maria Bulatova

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: info@benthamscience.net

Elena Shadrina

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: info@benthamscience.net

Oleg Chupakhin

Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: info@benthamscience.net

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