The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases


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Abstract

Meningeal lymphatic vessels (MLVs) are essential for the drainage of cerebrospinal fluid, macromolecules, and immune cells in the central nervous system. They play critical roles in modulating neuroinflammation in neurodegenerative diseases. Dysfunctional MLVs have been demonstrated to increase neuroinflammation by horizontally blocking the drainage of neurotoxic proteins to the peripheral lymph nodes. Conversely, MLVs protect against neuroinflammation by preventing immune cells from becoming fully encephalitogenic. Furthermore, evidence suggests that neuroinflammation affects the structure and function of MLVs, causing vascular anomalies and angiogenesis. Although this field is still in its infancy, the strong link between MLVs and neuroinflammation has emerged as a potential target for slowing the progression of neurodegenerative diseases. This review provides a brief history of the discovery of MLVs, introduces in vivo and in vitro MLV models, highlights the molecular mechanisms through which MLVs contribute to and protect against neuroinflammation, and discusses the potential impact of neuroinflammation on MLVs, focusing on recent progress in neurodegenerative diseases.

About the authors

Junmei Chen

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Email: info@benthamscience.net

Yaru Pan

Science and Technology Innovation Center, Guangzhou University of Chinese Medicin

Email: info@benthamscience.net

Qihua Liu

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Email: info@benthamscience.net

Guangyao Li

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Email: info@benthamscience.net

Gongcan Chen

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Email: info@benthamscience.net

Weirong Li

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Email: info@benthamscience.net

Wei Zhao

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Author for correspondence.
Email: info@benthamscience.net

Qi Wang

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine

Author for correspondence.
Email: info@benthamscience.net

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