Food safety: modern methods of multicomponent determination of pesticides

封面

如何引用文章

全文:

详细

Introduction. Analytical control of chemical contamination is essential in ensuring the safety of food products manufactured using pesticides. The development and testing of new methodological techniques for multicomponent measurement of the levels of residual amounts of biologically active ingredients are constantly in the field of view of analysts.

Research objectives. To assess the suitability of the QuEChERS methodological approaches for the determination of a wide range of pesticides of various structures and physicochemical properties (up to 50 names of active substances) in food products and food raw materials of various compositions and origins (fruits, vegetables, cereals, rice, tea, coffee, milk, eggs and their derivatives, meat, offal).

Material and methods. The measurements were carried out by tandem liquid chromatography-mass spectrometry and gas chromatography with a mass-selective detector, focused on screening and quantifying trace amounts of pesticides. The sample preparation procedure for analysis was carried out according to the QuEChERS method. 

Results. Multimethods have been created for the determination of residual amounts of pesticides in cereal grains (40 substances), fruits of vegetables and fruits (27 compounds), fruits of citrus crops (50 ingredients), 2,4-D acid in milk, eggs and by-products, fipronil and its toxic metabolite – sulfone in eggs, products of their processing (melange, dry egg white), muscle tissue and offal. The developments have supplemented the list of certified measurement methods included in the unified information fund of measurement methods of the Russian Federation.

Conclusions. The unification of analytical methods for preparing samples of food products of various composition and origin for analysis, instrumentation of analytical laboratories with liquid and gas chromatography-mass spectrometry systems expand the possibilities of introducing group methods, ensure the readiness of testing centres to perform multi-purpose tests to identify and measure pesticide levels.

作者简介

Valerii Rakitskii

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

编辑信件的主要联系方式.
Email: fake@neicon.ru
ORCID iD: 0000-0002-9959-6507
俄罗斯联邦

Natalia Fedorova

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: fedorovane@fferisman.ru
ORCID iD: 0000-0001-8278-6382

Dr. Sci. Biol., Federal Scientific Center of Hygiene named after F.F. Erisman, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Mytishchi, Moscow Region, 1410014, Russian Federation.

e-mail: fedorovane@fferisman.ru 

俄罗斯联邦

参考

  1. CODEX Online Glossary of Terms. Available at: https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/pestres/glossary/en/
  2. Food Safety Authority (EFSA). The 2019 European Union report on pesticide residues in Food. EFSA Journal. 2021; 19(4): 6491. https://doi.org/10.2903/j.efsa.2021.6491
  3. Klisenko M.A., ed. Methods for the Determination of Trace Amounts of Pesticides in Food, Feed and the Environment [Metody opredeleniya mikrokolichestv pestitsidov v produktakh pitaniya, kormakh i vneshney srede]. Moscow: Agropromizdat; 1992. (in Russian)
  4. Isaev L.K., ed. Control of Chemical and Biological Parameters of the Environment [Kontrol’ khimicheskikh i biologicheskikh parametrov okruzhayushchey sredy]. St. Petersburg: Soyuz; 1998. (in Russian)
  5. Hogenboom A.C., Niessen W.M.A., Brinkman U.A.T. The role of column LC-MS in environmental trace-level analysis. J. Sep. Sci. 2001; 24: 331.
  6. Budde W.L. Analytical mass spectrometry of herbicides. Mass Spectrom. Rev. 2004; 23(1): 1–24.
  7. Picό Y., Blasco C., Font G. Environmental and food applications of LC-MS-MS in pesticide-residue analysis: an overview. Mass Spectrom. Rev. 2004; 23(1): 45–85. https://doi.org/10.1002/mas.10071
  8. Anastassiades M., Lehotay S.J., Stajnbaher D., Schenck F.J. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “Dispersive solid-phase extraction” for the determination of pesticide residues in produce. J. AOAC Int. 2003; 86(2): 412–31.
  9. Anastassiades M., Mastovska K., Lehotay S.J. Evaluation of analyte protectants to improve gas chromatographic analysis of pesticides. J. Chromatogr. A. 2003; 1015(1-2): 163–84. https://doi.org/10.1016/s0021-9673(03)01208-1
  10. Lehotay S. J., de Kok A., Hiemstra M., van Bodegraven P. Validation of a fast and easy method for the determination of 229 pesticide residues in fruits and vegetables using gas and liquid chromatography and mass spectrometric detection. J. AOAC Int. 2005; 88(2): 595.
  11. European Committee for Standardization (CEN). Determination of pesticide residues using GC-MS(/MS) and/or LC-MS/MS following acetonitrile extraction/partitioning and cleanup by dispersive SPE – QuEChERS-method. CEN/TC 275 prEN 1556662; 2007. Available at: https://www.eurl-pesticides.eu/library/docs/cf/FP417%201%20%203%20%20udgave%20engelsk%20version.pdf
  12. AOAC Official Method 2007.01. Pesticide Residues in Foods by Acetonitrile Extraction and Partitioning with Magnesium Sulfate. Gas Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry First Action 2007. Available at: https://weber.hu/Downloads/SPE/QuEChERS/AOAC_2007_01.pdf
  13. Pang G.F., Liu Y.M., Fan C.L., Zhang J.J., Cao Y.Z., Li X.M., et al. Simultaneous determination of 405 pesticides residues in gran by accelerated solvent extraction then gas chromatography-mass spectrometry or liquid chromatograraphy-tandem mass spectrometry. Anal. Bioanal. Chem. 2006; 384(6): 1366–408. https://doi.org/10.1007/s00216-005-0237-9
  14. Kolberg D.I., Prestes О.D., Adaime M.B., Zenella R. Development of a fast multiresidues method for the determination of pesticides in dry samples (wheat grains, flour and bran) using QuEChERS based method and GC-MS. Food Chem. 2011; 125: 1436–42.
  15. Gonzalez-Curbelo M.A., Herrera-Herrera A.V., Ravelo-Perez L.V., Hernandes-Borges J. Sample-preparation methods for pesticide-residue analysis in cereals and derivatives. Trends Anal. Chem. 2012; 38: 32–51.
  16. He Z., Wang L., Peng Y., Luo M., Wang W., Liu X. Multiresidue analysis of over 200 pesticides in cereals using a QuEChERS and gas chromatography-tandem mass spectrometry-based method. Food Chem. 2015; 169: 372–80. https://doi.org/10.1016/j.foodchem.2014.07.102
  17. Analytical Quality control and method validation procedures for pesticide residues analysis in food and feed. SANTE/12682/2019, Supersedes Document № SANTE/2017/11813. Implemented by 01/01/2020.
  18. Analytical Method Report Analysis of Dithianon in Food of Plant Origin using acidified QuEChERS and LC-MS/MS. Available at: https://www.eurl-pesticides.eu/userfiles/file/EurlSRM/meth_Dithianon_EurlSRM.pdf
  19. Rakitskiy V.N., Fedorova N.E., Bayusheva V.V., Egorchenkova O.E., Bondareva L.G. Determination of 2,4-d in some food products (milk, eggs, liver, kidneys) by chromatography methods. Toksikologicheskiy vestnik. 2018; (1): 20–5. https://doi.org/10.36946/0869-7922-2018-1-20-25 (in Russian)
  20. Popova A.Yu., Rakitskiy V.N., Fedorova N.E., Lipkina L.I., Lar’kina M.V., Sobolev D.N., et al. Fipronil: chemical and analytical support for food safety control. Zdorov’e naseleniya i sreda obitaniya. 2018; 301(4): 10–4. https://doi.org/10.35627/2219-5238/2018-301-4-10-14 (in Russian)
  21. Klisenko M.A., Kalinina A.A., Novikova K.F., Khokhol’ko-va G.A. Methods for the Determination of Trace Amounts of Pesticides in Food, Feed and the Environment. Handbook. Volume 1 [Metody opredeleniya mikrokolichestv pestitsidov v produktakh pitaniya, kormakh i vneshney srede. Spravochnik. Tom 1]. Moscow: Kolos; 1992. (in Russian)

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Rakitskii V.N., Fedorova N.E., 2021

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ:  ПИ № ФС77-50668 от 13.07.2012 г.