Correction of Selenium status as a tool for preventive medicine

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Abstract

Introduction. Due to the many physiological functions of Selenium (Se), its deficiency is associated with a broad spectrum of adverse health effects. 

This review aims to analyze epidemiological data on the relation of selenium status to public health and the possibility of selenium-containing drugs usage. 

Material and methods. Based on the literature search in Pubmed, The Cochrane Library, and Google Scholar, epidemiological data on the association between Se status and population health and effects of Se supplementation were analyzed. 

Results. Meta-analyses indexed in the Cochrane Library demonstrated a significant association between Se status and many pathologies. Specifically, it has been shown that subjects with physiologically high Se body burden are characterized by a 24–31% lower risk of cancer and 36% lower risk of cancer-related mortality. It is also notable that Se supplementation in human immunodeficiency virus-infected women reduced the risk of maternal diarrhoea and low birth mass in offspring. Moreover, Se supplementation in premature newborns and critically low mass newborns significantly decreased the risk of sepsis. Many extensive epidemiological studies also demonstrated the efficiency of improvement in the Se status concerning coronary heart disease and sepsis mortality risk. At the same time, constant monitoring of Se body burden is essential for assessing Se supplementation efficiency and prevention of adverse health effects of Se overload. It is also noted that Se status is considered as the determinant of the efficiency of prevention of cardiovascular diseases and cancer under Se supplementation. 

Conclusion. Given the high incidence of Se deficiency in Russia (24–45% depending on the region), assessment and improvement of Se status may be considered a valuable tool for population health management.

About the authors

Aksana N. Mazilina

Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Biomedical Agency of Russia; Peoples’ Friendship University of Russia (RUDN University)

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0003-4785-2668
Russian Federation

Anatoly V. Skalny

Peoples’ Friendship University of Russia (RUDN University); I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7838-1366
Russian Federation

Valerii N. Rakitskii

F.F. Erisman Federal Research Center of Hygiene, Institute of Hygiene, Pesticides Toxicology and Chemical Safety

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9959-6507
Russian Federation

Aleksander S. Rusanov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0658-9130
Russian Federation

Lyubov N. Chernova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5498-1807
Russian Federation

Alexey A. Tinkov

Peoples’ Friendship University of Russia (RUDN University); I.M. Sechenov First Moscow State Medical University (Sechenov University); P.G. Demidov Yaroslavl State University

Email: tinkov.a.a@gmail.com
ORCID iD: 0000-0003-0348-6192

MD, PhD, Senior Researcher at the Center for Digital Biodesign and Personalized Health Care of Sechenov University, Moscow, 119991, Russian Federation.

e-mail: tinkov.a.a@gmail.com

Russian Federation

References

  1. Junior E.L., Leite H.P., Konstantyner T. Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes. Transl. Res. 2019; 208: 85-104. https://doi.org/10.1016/j.trsl.2019.01.004
  2. Fordyce F.M. Selenium deficiency and toxicity in the environment. In: Essentials of Medical Geology. Dordrecht: Springer; 2013: 375-416.
  3. Jones G.D., Droz B., Greve P., Gottschalk P., Poffet D., McGrath S.P., et al. Selenium deficiency risk predicted to increase under future climate change. Proc. Natl Acad. Sci. 2017; 114(11): 2848-53. https://doi.org/10.1073/pnas.1611576114
  4. Rayman M. Selenium intake and status in health & disease. Free Radic. Biol. Med. 2017; 112(S1): 5. https://doi.org/10.1016/j.freeradbiomed.2017.10.353
  5. Kipp A.P., Strohm D., Brigelius-Flohé R., Schomburg L., Bechthold A., Leschik-Bonnet E., et al. Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 2015; 32: 195-9. https://doi.org/10.1016/j.jtemb.2015.07.005
  6. Vinceti M., Filippini T., Wise L.A. Environmental selenium and human health: an update. Curr. Environ. Health Rep. 2018; 5(4): 464-85. https://doi.org/10.1007/s40572-018-0213-0
  7. Vinceti M., Vicentini M., Wise L.A., Sacchettini C., Malagoli C., Ballotari P., et al. Cancer incidence following long-term consumption of drinking water with high inorganic selenium content. Sci. Total Environ. 2018; 635: 390-6. https://doi.org/10.1016/j.scitotenv.2018.04.097
  8. Benstoem C., Goetzenich A., Kraemer S., Borosch S., Manzanares W., Hardy G., et al. Selenium and its supplementation in cardiovascular disease - what do we know? Nutrients. 2015; 7(5): 3094-118. https://doi.org/10.3390/nu7053094
  9. Zhang X., Liu C., Guo J., Song Y. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur. J. Clin. Nutr. 2016; 70(2): 162-9. https://doi.org/10.1038/ejcn.2015.78
  10. Rayman M.P., Duntas L.H. Selenium deficiency and thyroid disease. In: The Thyroid and Its Diseases. Cham: Springer; 2019: 109-26.
  11. Skalnyy A.V., Kiselev M.F., eds. The Elemental Status of the Population of Russia [Elementnyy status naseleniya Rossii]. St. Petersburg: Medkniga ELBI-SPb; 2013. (in Russian)
  12. Klimenko L.L., Skalny A.V., Turna A.A., Tinkov A.A., Budanova M.N., Baskakov I.S., et al. Serum trace element profiles, prolactin, and cortisol in transient ischemic attack patients. Biol. Trace Elem. Res. 2016; 172(1): 93-100. https://doi.org/10.1007/s12011-015-0586-y
  13. Skalny A.V., Klimenko L.L., Turna A.A., Budanova M.N., Baskakov I.S., Savostina M.S., et al. Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke. Metab. Brain Dis. 2017; 32(3): 779-88. https://doi.org/10.1007/s11011-017-9967-6
  14. Skalny A.V., Skalnaya M.G., Klimenko L.L., Mazilina A.N., Tinkov A.A. Selenium in Ischemic Stroke. In: Selenium. Cham: Springer; 2018: 211-30.
  15. Hu X.F., Eccles K.M., Chan H.M. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ. Int. 2017; 102: 200-6. https://doi.org/10.1016/j.envint.2017.03.002
  16. Virtamo J., Valkeila E., Alfthan G., Punsar S., Huttunen J.K., Karvonen M.J. Serum selenium and the risk of coronary heart disease and stroke. Am. J. Epidemiol. 1985; 122(2): 276-82. https://doi.org/10.1093/oxfordjournals.aje.a114099
  17. Bleys J., Navas-Acien A., Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch. Intern. Med. 2008; 168(4): 404-10. https://doi.org/10.1001/archinternmed.2007.74
  18. Merrill P.D., Ampah S.B., He K., Rembert N.J., Brockman J., Kleindorfer D., et al. Association between trace elements in the environment and stroke risk: The reasons for geographic and racial differences in stroke (REGARDS) study. J. Trace Elem. Med. Biol. 2017; 42: 45-9. https://doi.org/10.1016/j.jtemb.2017.04.003
  19. FAO, WHO. Human vitamin and mineral requirements. Report of a Joint FAO/WHO Expert Consultation. Bangkok, Thailand, Rome: Food and Nutrition Division, FAO; 2001: 235-47.
  20. Aro A., Alfthan G., Varo P. Effects of supplementation of fertilizers on human selenium status in Finland. Analyst. 1995; 120(3): 841-3. https://doi.org/10.1039/an9952000841
  21. Alfthan G., Eurola M., Ekholm P., Venäläinen E.R., Root T., Korkalainen K., et al. Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population. J. Trace Elem. Med. Biol. 2015; 31: 142-7. https://doi.org/10.1016/j.jtemb.2014.04.009
  22. Lyons G.H., Judson G.J., Ortiz-Monasterio I., Genc Y., Stangoulis J.C., Graham R.D. Selenium in Australia: selenium status and biofortification of wheat for better health. J. Trace Elem. Med. Biol. 2005; 19(1): 75-82. https://doi.org/10.1016/j.jtemb.2005.04.005
  23. Cai X., Wang C., Yu W. Selenium exposure and cancer risk: An updated meta-analysis and meta-regression. Sci. Rep. 2016; 6: 19213. https://doi.org/10.1038/srep19213
  24. Vinceti M., Dennert G., Crespi C.M., Dennert G., Zwahlen M., Brinkman M., et al. Selenium for preventing cancer. Cochrane Database Syst Rev. 2014; 2014(3): CD005195. https://doi.org/10.1002/14651858.CD005195.pub3
  25. Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004; 364(9441): 1219-28. https://doi.org/10.1016/S0140-6736(04)17138-9
  26. Lee E.H., Myung S.K., Jeon Y.J., Kim Y., Chang Y.J., Ju W., et al. Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutr. Cancer. 2011; 63(8): 1185-95. https://doi.org/10.1080/01635581.2011.607544
  27. Fritz H., Kennedy D., Fergusson D., Fernandes R., Cooley K., Seely A., et al. Selenium and lung cancer: a systematic review and meta-analysis. PLoS One. 2011; 6(11): e26259. https://doi.org/10.1371/journal.pone.0026259
  28. Siegfried N., Irlam J.H., Visser M.E., Rollins N.N. Micronutrient supplementation in pregnant women with HIV infection. Cochrane Database Syst. Rev. 2012; (3): CD009755. https://doi.org/10.1002/14651858.CD009755
  29. Darlow B.A., Austin N.C. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst. Rev. 2003; (4): CD003312. https://doi.org/10.1002/14651858.CD003312
  30. Flores-Mateo G., Navas-Acien A., Pastor-Barriuso R., Guallar E. Selenium and coronary heart disease: a meta-analysis. Am. J. Clin. Nutr. 2006; 84(4): 762-73. https://doi.org/10.1093/ajcn/84.4.762
  31. Huang T.S., Shyu Y.C., Chen H.Y., Lin L.M., Lo C.Y., Yuan S.S., et al. Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS One. 2013; 8(1): e54431. https://doi.org/10.1371/journal.pone.0054431
  32. Alhazzani W., Jacobi J., Sindi A., Hartog C., Reinhart K., Kokkoris S., et al. The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit. Care Med. 2013; 41(6): 1555-64. https://doi.org/10.1097/CCM.0b013e31828a24c6
  33. Landucci F., Mancinelli P., De Gaudio A.R., Virgili G. Selenium supplementation in critically ill patients: a systematic review and meta-analysis. J. Crit. Care. 2014; 29(1): 150-6. https://doi.org/10.1016/j.jcrc.2013.08.017
  34. Zou K., Liu G., Wu T., Du L. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthritis Cartilage. 2009; 17(2): 144-51. https://doi.org/10.1016/j.joca.2008.06.011
  35. Toulis K.A., Anastasilakis A.D., Tzellos T.G., Goulis D.G., Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010; 20(10): 1163-73. https://doi.org/10.1089/thy.2009.0351
  36. Lenz M., Lens P.N. The essential toxin: the changing perception of selenium in environmental sciences. Sci. Total Environ. 2009; 407(12): 3620-33. https://doi.org/10.1016/j.scitotenv.2008.07.056
  37. Stranges S., Sieri S., Vinceti M., Grioni S., Guallar E., Laclaustra M., et al. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. 2010; 10: 564. https://doi.org/10.1186/1471-2458-10-564
  38. Vinceti M., Bonvicini F., Rothman K.J. The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study. Environ. Health. 2010; 9: 77. https://doi.org/10.1186/1476-069X-9-77

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Copyright (c) 2021 Mazilina A.N., Skalny A.V., Rakitskii V.N., Rusanov A.S., Chernova L.N., Tinkov A.A.

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