Features of the course and outcomes of Haff disease in the territory of the Tyumen region

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Purpose is to identify the features of the clinical picture, course and outcomes of Haff disease in the Tyumen region.

Materials and methods. A retrospective study was conducted. There were included nine patients (7 men and 2 women) with a diagnosis of “Alimentary-toxic paroxysmal myoglobinuria (Haff disease) (T62.8)”. Were collected original demographics (age, gender), symptoms, time to onset of initial symptoms, time to hospitalization, and laboratory tests (general blood analysis, biochemical analysis of blood, analysis of blood coagulation functions and of arterial blood gases).

Results. 4 (44.4%) patients had stage 3 severity, in 3 (33.3%) — stage 2 severity and in 2 (22.3%) — stage 1 severity of alimentary-toxic paroxysmal myoglobinuria. The main complaints presented by patients at the moment admissions were pain in the leg muscles (n = 6; 66.7%) and lower back (n = 6; 66.7%), dark urine (n = 5; 55.5%) and weakness (n = 4; 44.4%). Myoglobin, ALT, AST, LDH, CPK and CPK-MB were increased in all patients, the average level of these indicators was 4691.4 ± 2831.5 ng/ml, 1572.0 ± 547.5 U/L, 547.3 ± 158.2 U/L, 1555.7 ± 420.6 U/L, 33662.4 ± 15195.7 U/L and 1848.8 ± 692.6 U/L, respectively. The main complications developed in patients with stage 3 severity include acute renal and hepatic insufficiency and cardiomyopathy. Milder degrees of the disease (1–2 stages) were characterized by such complications as hepatitis and myocarditis. Also 1 death was observed, the analysis of this clinical case is analyzed in detail.

Limitations. The main limitation of the study is the small group of patients due to the rare occurrence of Huff disease. In addition, there are no data on the amount of eaten fish, while there is evidence of a direct relationship between the severity of the disease and the amount of eaten food. The results are obtained in this region, and may differ from the results of other territories.

Conclusion. with the development of myalgia or weakness of unknown etiology, it is necessary to ask patients if they have eaten fish in the previous 24 hours.

Compliance with ethical standards. The study was approved at a meeting of the Ethics Committee of the Tyumen State Medical University (protocol No. 112, February 13, 2023). All patients signed an informed consent to participate in the study. All methods used in the study were carried out in accordance with the legislation of the Russian Federation.

Contribution of the authors:
Lebedeva D.I. — research concept and design, writing the text, compilation of the list of literature, statistical data processing;
Marchenko A.N. — writing the text, statistical data processing, editing;
Sharuho G.V. — collection and processing of material;
Raspopova Yu.I. — collection and processing of material;
Turovinina E.F. — writing the text, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: February 28, 2023
Accepted: March 30, 2023
Published: April 28, 2023

Sobre autores

Djinna Lebedeva

Tyumen State Medical University; Regional Medical and Rehabilitation Center

Autor responsável pela correspondência
Email: j.lebedeva1965@mail.ru
ORCID ID: 0000-0003-2478-9619

MD, PhD, DSci., Associate professor of the Department of Medical Prevention and Rehabilitation of the Institute of Public Health and Digital Medicine of the Tyumen State Medical University, Tyumen, 625023, Russian Federation.

e-mail: j.lebedeva1965@mail.ru

Rússia

Aleksandr Marchenko

Tyumen State Medical University

Email: noemail@neicon.ru
ORCID ID: 0000-0002-8286-0279
Rússia

Galina Sharuho

Tyumen State Medical University; Department of Rospotrebnadzor in the Tyumen Region

Email: noemail@neicon.ru
ORCID ID: 0009-0002-8931-7022
Rússia

Yulia Raspopova

Department of Rospotrebnadzor in the Tyumen Region

Email: noemail@neicon.ru
ORCID ID: 0000-0002-5754-6755
Rússia

Elena Turovinina

Tyumen State Medical University

Email: noemail@neicon.ru
ORCID ID: 0000-0002-6585-0554
Rússia

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