THE EVALUATION OF NOISE EFFECT ON BIOCHEMICAL INDICES OF ENDOTHELIAL DYSFUNCTION IN WORKERS OF SELWYNITE ORE-DRESSING AND PROCESSING ENTERPRISE

The labor conditions of workers of key professions of selwynite concentrating manufacture (drying machine operative, granulation machine operative, dosing of drying-granulating room machine operative, centrifuge operative, filtration operative, transporter of drying granulating room, engineer of mill machine) are characterized by effect of physical factors of industrial environment. The noise is the most significant of them. It is established that level of noise at working places of workers of analyzed specialties attains 83-98 dBA that on 18 dBA is higher of maximum permissible level of 80 dBA. In examined workers a reliable increasing of level of homocysteine and lipoprotein (a) up to 3.8 times is established against the background of decreasing of production of nitric oxide in blood serum up to 1.2 times and increasing of level of malonic di-aldehyde up to1.3 times relatively to similar indices in workers of comparison group. The consequence of these processes can be a disorder of structure and endothelial function of vessels, increasing of permeability of endothelium, loss of its elasticity and as a consequence disorder of functional activity of vessel wall. The substantiation is given to indicator indexes (level of lipoprotein (a), homocysteine in blood serum and content of malonic di-aldehyde in blood plasma), having higher and average degree of occupational conditionality and forming biochemical profile of endothelial dysfunction as a predictor of arterial hypertension in workers of selwynite ore-dressing and processing enterprise undergoing effect of noise. The given biochemical indices are appropriate to be applied in early diagnostic and prevention of endothelial dysfunction in workers of the mentioned enterprises.

ore-dressing and processing enterprise, lipoprotein (a), homocysteine, nitric oxide, malonic di-aldehyde, endothelial function