Synthesis, anti-inflammatory, analgesic and antyregifying properties of azomethine derivatives of the tetrahydropyrane series

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Authors: Isakhanyan A.U.¹, Hakobyan N.Z.¹, Muradyan R.E.¹, Tumadzhyan A.Y.¹, Panosyan H.A.¹, Harutyunyan A.A.¹
Affiliations:
1. The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Issue: Vol 61, No 5 (2025)
Pages: 636-640
Section: КРАТКОЕ СООБЩЕНИЕ
URL: https://hum-ecol.ru/0514-7492/article/view/692397
DOI: https://doi.org/10.31857/S0514749225050164
ID: 692397

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Abstract
About the authors
References
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Abstract

Azomethine derivatives of the tetrahydropyran series have been synthesized in a dry benzene by condensation of the corresponding amines with 4-chlorobenzaldehyde, 4-fluorobenzaldehyde, 4-(dimethylamino)-benzaldehyde, and thiophene-2-carbaldehyde. The anti-inflammatory, analgesic and antipyretic properties of the synthesized compounds have been studied.

Keywords

azomethines, amines, condensation, tetrahydropyran series, anti-inflammatory activity, carrageenan and chronic inflammation

About the authors

A. U. Isakhanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
ul. Azatutyan, 26, Yerevan, 0014 Armenia

N. Z. Hakobyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ul. Azatutyan, 26, Yerevan, 0014 Armenia

R. E. Muradyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ul. Azatutyan, 26, Yerevan, 0014 Armenia

A. Y. Tumadzhyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ul. Azatutyan, 26, Yerevan, 0014 Armenia

H. A. Panosyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ul. Azatutyan, 26, Yerevan, 0014 Armenia

A. A. Harutyunyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

ul. Azatutyan, 26, Yerevan, 0014 Armenia

References

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European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. Strasbourg. No 123.18.03.1986. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes.
Арутюнян Н.С., Акопян Л.А., Акопян Н.З., Пано- сян Г.А., Геворгян Г.А. ЖОрХ. 2011, 47 (1), 116–120. [Arutyunyan N.S., Akopyan L.A., Akopyan N.Z., Panosyan G.A., Gevorgyan G.A. Russ. J. Org. Chem. 2011, 47, 115–119.] doi: 10.1134/S1070428011010143

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