Vol 19, No 3 (2012)

The connection of thermodynamic properties and parameters of toxicity of chemical substances were determined. The obtained data was used for evaluation of toxicity and hygienic rate setting of chemical combinations. Toxicological investigations in the conditions of acute and chronic experiment have been carried out. The connection of enthalpy and toxicity of chemical combinations has been determined. The data of determination of toxicity, regulation of chemical substances has been shown. The equation of united hygienic rate setting in combined, complex, conjunct influence on the organism has been presented.

There was surveyed a character of brain bioelectric activity change during carrying out of biofeedback sessions by heart rate variability parameters (HRV biofeedback) in adolescents aged 15-17 years with different initial autonomic nervous tone. It has been established, that adolescents with the optimal autonomic nervous tone have high reactance of both autonomic nervous system parts. At the end of HRV biofeedback course there is more significant vagal activity increase accompanied in some cases by depression of peakfrequency electroencephalogram characteristics. There was observed in adolescents with prevalence of sympathetic influences on heart rate activity against decreasing of arterial blood pressure less expressed reaction of heart rate indicators and brain functional activity optimization after the course of HRV biofeedback sessions.

To provide more accurate stratification models, one should systematically review the figures. In 2010, there was a re-organized multicenter study team of researchers from Papworh Hospital (Cambridge, UK). The project EuroScore II involved 154 centers from 43 countries. One of three Russian centers participating in the project was the Department of Cardiac Surgery of the City Hospital N 1 named after E. E. Volosevitch, Arkhangelsk. Purpose. Participation in a multicenter study EuroScore II for development of modern models of risk stratification of cardiac operations. Methods. There were examined 113 patients over 18 y.o. operated in May-June 2010. Complicated (nonlethal) postoperative period in patients who underwent myocardial revascularization, was observed in 19.5 % of cases, heart valves replacement / repair - in 21.1 %, the combined procedure - in 45.5 %, ascending aorta and aortic arch replacement / repair - in 0 % of cases respectively. Predicted hospital mortality among the patients who underwent myocardial revascularization was 3.7 %, heart valves replacement / repair - 5.3 %, the combined procedure - 18.2 %, ascending aorta and aortic arch repair - 100 % respectively. Conclusions. Use of scale EuroScore I may become less relevant, because there is an expansion of indications for cardiac surgery, due to improved surgical techniques, anesthesia and technical equipment provision. Scale EuroScore II may allow better assessment of cardiac surgery risk.

the aim of the work was to study interrelations between blood activity and microbiocenosis of the large intestine in chronic viral hepatitis with the use of probiotic correction. Methods. To assess the condition of the liver and large intestine microbiocenosis, a case-control study of patients with CHB, CHC was conducted. Biochemical and microbiological parameters in patients with chronic hepatitis B and CHC have been compared with healthy individuals (the control group). For a comparative analysis of these samples’ differences, the Mann-Whitney test and Fisher test were used. Results. The liver disease of viral origin was manifested in 2-3times increase in activity of serum enzymes, microbiocenosis disorders of the large intestine (lower numbers of bifidobacteria - 10 6 CFU/g and lactobacilli - 10 3 CFU/g, 30 % increase of frequency of occurrence of S. aureus and reduction to 45 % of enterococci), and voltage mismatch intersystem links (links to the weakening of (τ = 0.26)). Conclusions. Use of probiotic preparations in treatment helps to restore the liver functions by means of increased functions of the large intestine microflora that is manifested in decreased activity of enzymes, increased content of representatives of obligate microflora up to physiological values and reduced frequency of occurrence of opportunistic pathogens, recovery of the interaction of the liver and the large intestine microbiocenosis (strengthening ties to (t = 0.56)).

Professional preferences of the second year students of a medical university were studied according J. Holland questionnaire. It was discovered that among students there prevailed research and social professional personal types.