Vol 25, No 5 (2018)

The problem of road traffic injuries is one of the prioritized social, medical and technological problems all over the world. The timeliness of medical care provision is of great social and economic importance. In recent years, more attention is paid to the development and improvement of drug provision, which is essential in saving lives of victims in road accidents (road accidents). The aim of our study is the development of new approaches to needs identification and creation of balanced drugs list for provision emergency medical care to victims of road traffic accidents. Methods. A visualization framework, allowing to solve the task, is the development of an intellect card "Drug Provision of Victims in Road Traffic Accidents" which makes it possible to systematize and summarize the large content of research related to planning and identification of needs. As s result, the efficiency of financial resources disbursing increases, the time for the drugs systematization and the medical standards analysis reduces. The results. The intellect card consisting of four stages: the problem study of medical assistance organization to the victims of road traffic accidents, analysis of drugs efficient use in providing medical assistance, efficient choice of drugs, method development of requirement estimation in drugs and financial resources was created. Conclusions. The results of the intellect card creation pointed necessity and relevance of new drugs list formation, regulated drug provision to the victims of road traffic accidents. Organizational steps and work criteria with the standards of rendering emergency medical care, requirement estimation in necessary medications were proposed.

Aim of investigation. To study the content of heavy metals: zinc, iron, copper, lead, arsenic, manganese, chromium, cadmium and mercury in hair samples of children permanently residing on the territory of the Arctic zone of Russia. Methods. In the process of research, a method of atomic absorption spectrometry with flame and electrothermal atomization, the cold vapor method was used. In the transverse study, 48 children aged 7 to 17 years were involved. Hair sampling was performed from the occipital part of the head. Hair represents an ideal object of research and is one of the informative tissue structures of a person. The obtained results were compared with the reference values established for residents of the Volga and Ural federal districts of the Russian Federation. Results. Exceed-ances of the recommended values for copper, iron, manganese and zinc in 100.0 %, 66.7 %, 25.0 % and 22.2 % samples respectively in the children of Salekhard at the age of 7-11; and iron, copper, chromium, zinc and manganese in 70.0 %, 50.0 %, 44.4 %, 40.0 % and 20.0 % of samples respectively for the children of Salekhard at the age of 13-16 years. The children of the village of Yar-Sale, two age groups have exceeded the recommended levels for iron, chromium, copper and zinc, the percentage of such samples for children aged 7 to 11 years was 100.0 %, 85.7 %, 57.1 % and 7.1 % respectively, and for children from 13 to 17 years- 100.0 %, 86.7 %, 13.3 % and 13.3 % respectively. Conclusion. The conducted studies on the study of heavy metals in hair of both age groups of children in in settlement Yar-Sale and city Salekhard found exceedances of recommended values for zinc, copper, iron, chromium (except for the age group of children of 7-11 years of Salekhard) and manganese (for children living in Salekhard).

A high rate of change in the composition of saliva can be used to monitor biorhythms (seasonal and circadian). Research objective -the study of the dynamics of the near-24-hour mineral composition of saliva in men and women. Methods. The study involved 40 people (20 men, 20 women, age 23.1 ± 0.9 years). Saliva samples were collected every 3 hours during the day. The mineral composition of saliva was defined by the capillary electrophoresis technique. The cross-group differences were evaluated using the non-parametric criterion. Results. It is shown that the sodium concentration reaches its maximum values at night (9.67 mM), and then monotonously decreases to 12-15 p.m. (5.72 mM). For potassium concentration, the maximum is observed around 12 p.m. (10.71 mM), remains at a stably high level until 21 p.m., after which it decreases until 6:00 a.m. in the morning (8.78 mM). For the Na/K ratio, one maximum is observed, corresponding to 3 a.m. in the night (Na/K = 1.257), and one minimum at 12-13 p.m. (Na/K = 0.666; р = 0.0082). Conclusion. Thus, the diurnal dynamics of the parameters studied is characterized by pronounced periodicity. The revealed regularities are caused by a change in the rate of saliva secretion during the day, and by the action of hormones.

The aim of the article is the conceptual and methodological generalization and systematization of new studies on neuroepigenetics for the development of the technological platform of mental medicine (MM). MM is one of the newest examples of reformatting yesterday's nosocentric boundaries and early pre-nosological forecasting of tomorrow's possible mental ailments. The substantiation for the functional lateralization of mentality (mental asymmetry) as one of the tools of neuroepigenetic coding of identity and behavior is proposed. MM harmoniously combines in its technological platform genetic and epigenetic molecular mechanisms, socio-psychological and clinical-psychopathological, spiritual-moral and religious-integrated tools. This allows MM to practically implement yesterday's "neuroepigenetic fantasies" about editing and formatting the design of the network cascade of genetic and epigenetic identity: molecular - cellular - tissue - organ - organism - personal - social - population. The degree and the vector of dispersion of genomic and epigenomic identity reflect possible resources of evolutionary variability embodied in the registers of mental immunity (MI) and manifested by the mental resilience. MI is a neural network multisystem and multimodal identity interface in its interaction with the internal and external environment. The identified basic functional characteristics of MI are modeled by epigenetic switches or labels, and are embodied in behavioral phenomenology or pathoplastics and pathokinetics of mental disorders. The epidemic increase in the prevalence of mental and psychosomatic disorders is suggested to be called the pandemic of mental immune deficiency (PMID) by the name of the earliest and nonspecific syndrome of mental immune deficiency accumulating initial manifestations of MI dysfunctions transgenerationally. The global predictors of PMID are many of the challenges of the modern world: from the psychic traumatization of childhood to cumulative existential stress. In MM sanogenetic therapy as adaptive modulation of MI triggers cascade self-renewal of personality, clinically manifested by its therapeutic drift (diagnoses-syndromes-symptoms-states). The well-known expression of Nobel Laureate Peter Medawar: "Genetics proposes and epigenetics disposes" should be supplemented with a practically significant mission of MM, which embodies the design models of quality and style, the way and meaning of life in adaptive neuroengineering and self-management of consciousness and health.

Aim - to identify patterns of the diffuse endemic goiter incidence in adolescents and adults living in different bioclimatic zones and ecological conditions in Primorsky region. Methods. Methods of descriptive statistics and environmental-hygienic evaluation. To assess the reliability of the difference in the indicators, the Pearson criterion was used. The territory of Primorsky region was classified into bioclimatic zones and zones of ecological situation in previously conducted research. Results. It should be noted that in the continental and coastal bioclimatic zones with a relatively favorable level of ecological situation, the incidence of the investigated nosology was higher (in the range of 1 699.1-2 399.9 per 100 000 adolescent population, 702.7-290.1 per 100 000 of the adult population) than in areas with a relatively satisfactory and tense level of environmental situation (93.6-1 423.2 per 100 000 adolescents, 46.5-668.6 per 100 000 adults). The transitional bioclimatic zone was marked by a high level of morbidity in a critical ecological situation (4 844.7 in adolescents, 617.0 in adults) and a stressed environmental situation (1 736.5 in adolescents, 490.1 in adults). Conclusion. Revealed regularity suggests the existence of group of previously neglected factors, taking part in formation of thyroid pathologies, associated with iodine deficiency in Primorsky region. The impact study on the population will help to develop the full picture of dependence appearance of iodine deficiency disorders from environmental factors in the region