Vol 24, No 4 (2017)

The regional characteristics of the epidemic process and the incidence rates of tick-borne encephalitis (TBE) in the Arkhangelsk region have been examined in the paper. In the period 2005 -2015 the annual TBE incidence rates per 100 thousand population were from 2,0 to 5,4 times higher as compared to the corresponding averages reported for the whole population of the Russian Federation. The most possible causes of the increased incidence rates of tick-borne viral encephalitis in the Arkhangelsk region and temporal trends in its changes as well as potential risk factors of TBE extension have been stated. The vectors of viral encephalitis in the Arkhangelsk region are represented by two types of ixodic ticks: Ixodes persulcatus (the "taiga" tick) and Ixodes ricinus ("forest" tick), the Ixodes persulcatus constitutes over 99 % of their total number. Spring-summer season is typical for TBE cases occurrence which is associated with higher tick activity in this area. The average tick infection rate for the period was 7.8 %. The cases of TBE are reported to occur mainly in urban citizens; and lethality rate due to TBE reached 4.3%. Since 2010 decrease in the TBE morbidity has being observed in the Arkhangelsk region. Reducing morbidity can be connected to the increase in the proportion of vaccinated persons, which reached 6.3 % of the total population of the Arkhangelsk region. The main indices of the acaricide treatment volume which increased since 2005 nearly 6 times, from 128.2 to 740.0 hectares have been stated. Considering the fact that the area of acaricide treatment in the region increases every year, and the number of persons seeking medical advice concerning tick bites remains high it is necessary to control the effectiveness of acaricide treatment regularly. Core measures to decrease the tick-borne viral encephalitis conducted by the Regional Office of Federal Service for Consumers' Rights Protection and Human Wellbeing as well as ways for further research have been introduced.

Conceptual and methodological, instrumental and technological resources of mental medicine (MM) in the diagnostics and treatment of autism spectrum disorders (ASD) are systematized in the article. Mental medicine is a system synthesis of clinical psychiatry (thesis) and anti-psychiatry (antithesis) that continuingly and harmoniously integrates preventive and correctional, treatment and rehabilitation approaches. With the creation of mental medicine, anti-psychiatry century ends and a new stage in the development of clinical neuroscience begins based on a synergetic multidimensional methodology. Isolation of the mental immunodeficiency syndrome (MIS) is justified as the pathogenic mental disorder of mental immunity (MI). MI is biopsychosociospiritual matrix of identity and the basis of personal security. Identity is self-determination (for children self-perception) of an individual in terms of his physical and mental, social and moral traits. The synergetic functional diagnostics (SFD) is proposed as an expanded mental 4D-mapping, which gives not only clinical, psychological, social and spiritual evaluation of phenomenology, but also helps to identify the preserved and potentially claimed new resources of personalized assistance and adaptation enhancement. Definition of standard functions of MI is given. Clinical phenomenology of MIS is provided manifesting in disorders of identity and communication. MIS can be congenital and early, childhood and late, acquired or induced. The technological platform of mental medicine is revealed, synergetically accumulating molecular genetic and medical-biological, social and psychological, spiritual and moral resources that increase the effectiveness of the early intervention due to the screening batteries of mental 4D-mapping and multidisciplinary brigade block-modular assistance programs. Pathogenetic treatment of MIS is sanogenetic therapy - adaptive engineering and management of mind and health for the recovery of mental immunity. The article gives examples of the positive regional experience in the implementation of pilot models. Autism as a "mystery of the nineteenth century" was isolated and developed by many prominent psychiatrists. The modern ASD became "a problem of the twentieth century", breaking out of the nosocentric boundaries of the clinical psychiatry. The demand for a synergetic scientific-practical paradigm of the MM has emerged, particularly in the made by us allocation of MI and MIS, having become one more step that makes neurosciences closer to the tomorrow "opening of the XXI century".

The formation of M.V. lomonosov personality is specified due to the peculiarities of the socio-cultural environment of the Russian North. The scientific heritage of the first Russian academician has tragic history and fate. His people's memory was kept by progressive figures of the region, the priests, who suggested the need to explore the heritage and the biography of the scientist and raise up a monument to him in Arkhangelsk. A significant role in commemoration and exploring the scientific heritage of lomonosov had his anniversaries: 1865, 1911, 1961, 1986, 2011. The paper first examines the history of popular initiatives of northerners to commemorate the first Russian academician - M.V. lomonosov. On the basis of historical materials such selfless initiatives as: the perpetuation of the scientist's name; educational initiatives; support for young people seeking education and science; strategic initiatives are compiled. The article presents, in chronological order, their various forms: fundraising money for scientist monuments; promotion of lomonosov awards and scholarships; organization of lomonosov readings; creation of lomonosov Fund; the formation of the Arkhangelsk region as the university center, etc. The author shows the development of lomonosov movement in the region as a popular initiative. The paper reveals the perspective popular initiative to create at lomonosov homeland the historical, cultural and scientific complex "lomonosov manor", which branches may be placed in the different areas of the region.

Consequences of medical drugs use have been a subject of scientific research, both in terms of long-term effect on the gene pool of populations and immediate effects on human health. Drug-drug interactions (DDI) is an important and still insufficiently recognized cause of medical errors and costs for the healthcare system. We have studied the prevalence and structure of DDI in hospitals of West Kazakhstan. We performed a retrospective analysis of pharmacotherapy in a systematic sample of 730 patients with cardiovascular diseases treated in the hospitals of Aktobe, Uralsk, Atyrau cities in 2014. Potentially dangerous DDI were identified using Drug Interaction Checker source (FDA). The prevalence of major and moderate potential DDI and their structure were studied. Associations between DDI and other studied variables were estimated using odds ratios (OR) and chi-squared tests. For all estimates 95 % confidence intervals (CI) were calculated. We found a high prevalence of major and moderate DDI (53,8 (95 % CI 50,9-58,3) % and 88,1 (95 % CI 85,590,3) %, respectively. We found out that 53,8 % of patients were treated with at least one potentially inappropriate combination. The effect of age (OR 1,8, p < 0,001, 95 % CI 1,4-2,5) and polypragmasy (OR 6,0, р < 0,001, 95 % CI 2,7-13,1) on potentially dangerous DDI were revealed. Adverse drug effects were diagnosed in 4,1 % of patients, they were more frequently observed in patients with more prescriptions (р = 0,001). The most frequent drugs creating a dangerous combination were spironolactone, ACE inhibitors, enoxaparinm sodium, fondaparinux sodium, clopidogrel, potassium chloride, sartana.