Vol 22, No 1 (2015)

In the article, there have been presented the results of the occupational diseases risk prediction in assemblers of vessel metal hulls (VMH) of the Northern Region Machine Building Plant. Assessment of the VMH assemblers working conditions has been made on the ground of the materials of the assessment of workplaces and sanitary and hygienic characteristics of the working conditions composed for the patients suspected of having occupational diseases according to Guidance Р 2.2.2006-05. The occupational diseases risk has been predicted on the ground of the hygienic criteria of assessment of working conditions, as well as the regulatory and methodical documents approved in the established procedure. It has been determined that according to the harmful factors impact stated in Guidance Р 2.2.2006-05, the VMH assemblers working conditions were referred to hazard classes 3.2 and 3.3 described by high antecedent risk of occupational diseases in the period of working activity, what was confirmed by the long-term average annual levels of occupational morbidity that significantly (p<0.001) exceeded similar indices in the control group (employees of the machine workshops). On the ground of the made assessment of the working conditions and the results of the occupational diseases antecedent risk prediction, managerial decisions focused on preservation of the VMH assemblers health should foresee implementation of top-priority measures for reduction of local vibration and noise generated by hand tools, as well as optimization of microclimate parameters and labor burden reduction.

The assessment of standard energy metabolism has been measured in rats after per os introduction of a new antihypoxic metal-complex substance πQ1983 with a dose 100 mg/kg. The well-known antihypoxant amthizole was used as a substance for comparison in the same dose. It had been established that 90 min after using πQ1983, activity of body energy processes decreased from 194.4 ± 0.7 kcal/day/kg (the control group) to 74.5 ± 0.5 kcal/day/kg (πQ1983), but the effect of amthizole was not reliable. It has also been revealed that both substances (πQ1983 significantly, amthizole slightly) decreased the rats' oxygen consumption rate during rising acute exogenous hypoxia that could increase the animals' resistance to the oxygen deficit. Probably, the decreased oxygen consumption was caused by the inhibitory effects of the studied substances, especially that of substance πQ1983, on body energy-intensive processes.

The article has emphasized the problem of injuries related to alcohol consumption. An analysis of contemporary research on this topic and own data have been given. Intoxicated patients had more severe injuries, a more serious course of illness, a greater incidence of complications and mortality. Alcohol intoxication provoked formation of delayed intracranial hematomas. The tendency to form multiple intracranial hematomas and subarachnoid hemorrhages in alcohol abusers was explained by atrophic processes in the brain, subdural spaces extension, toxic lesions of the cerebral vessels. Intoxicated patients should be regarded as a high-risk group in terms of availability of severe traumatic brain injuries, as their condition

Arterial hypertension (AH) is an ultimate non-infectious pandemic in human history that determines the cardiovascular morbidity and mortality structure. Despite significant advances in understanding the disease pathogenesis and modern strategies in hypertension management, it is still one of the most relevant medical social problems that require development of a multidisciplinary approach to etiopathogenesis and clinical picture, preventive-correctional and medical-rehabilitation aid. A synergetic conception of AH including three prenosological fractals: predisposition - hypertensive family, latent - hypertensive diathesis, initial - prehypertension, and three nosological fractals: onset of disease, chronization and outcome, has been proposed. The mechanisms of development of the AH social epidemic and the program of medical-psycho-socio-spiritual aid have been grounded.