Vol 27, No 11 (2020)

The aim of the study was to assess changes in serum concentrations of pro- and anti-inflammatory cytokines in patients with vibration disease (VD). Methods. In total, 28 patients with VD associated with the combined effects of local and general vibration comprised the study group while 24 men were included in the reference group with no exposure to vibration in their professional activities. Serum concentrations of IL-2, IL-4, IL-8, IFN-y) were measured by enzyme-linked immunosorbent assay. The severity of neuroenergy exchange was assessed using the neuroenergy mapping method based on measuring the levels of constant potential (DC-potential level). Data were analyzed using Shapiro-Wilk test, Student test, Mann-Whitney test, Fisher's angular transformation method and Spearman's rank correlation. Results. The proportion of study participants with increased brain DC-potential level was greater (67.9 %) among patients with VD (p = 0.001). The concentration of IL-8 was 24.29 (14.42-65.16) pg / ml in the VD-group vs. 14.35 (6.24-19.14) pg / ml. in the comparison group. Concentration of IFN-y - was 21.38 (1.68-94.28) pg / ml. in the VD-group vs. 0.01 (0.01-0.28) pg / ml in the reference group. We observed significant correlations between the levels of IL-4, IL-8, TNF-γ and DC-potential (rs = 0.61; 0.55; 0.57, respectively) suggesting their role in disruption of the processes of neuroenergy exchange. Conclusions. More than two thirds of patients with VD have an increased DC-potential level and greater concentrations of IL-8 and TNF-y. Disrupted functioning of the mechanisms of cytokine regulation seems to be associated with neuuroenergy exchange and may activate neuroinflammatory processes.

One of the main problems in the theory of homeostasis and the theory of functional systems of the human body is the problem of choosing standards. It turned out that the statistics poorly diagnose the norm (standard) of function of the human body. The aim of the study was to assess the possibility of using a new quantitative criteria - the area of the pseudoattractors (Eskov's quasiattractors) as standard (physiological norm) parameters. Methods. In a group of 15 women (mean age = 28 ± 2,3 years, who have been living in the North of the Russian Federation in Ugra for more than 15 years), cardiointerval samples were recorded (300 cardiointervals per sample) 225 times for each test subject. As a result, we calculated 15 matrices of pairwise comparisons of samples. A total of 225 matrices for all 15 subjects and 225 areas of S pseudoattractors for each subject were created. Area S was found from the formula S = Δx1 х Δх2, where Ax1 is the range for cardio intervals, and Δx2 is the range for Δx1. Results. All 225 matrices for 15 subjects showed showed a substantial variability in samples of cardiointervals. However, S areas showed statistical stability for each of 15 subjects. Conclusions: further application of statistics in the calculation of cardio intervals is problematic due to the statistical instability of the samples, therefore we propose to use areas of pseudoattractors to assess the physiological norm.

The aim of the study was to assess and compare the main anthropometric characteristics of children aged 8 to 14 years living in three northern cities. Methods. The consisted of schoolchildren living in St. Petersburg (n = 4 621), Surgut (n = 3 606) and Novy Urengoy (n = 1 101). Indigenous ethnic groups were not included. Body weight and height were measured. Arithmetic means (M), standard deviations (SD) and 95 % confidence interval (CI) were calculated. Between-groups comparisons were performed by independent-samples t-tests. The level of significance was set as 0,017 using Bonferroni correction. Results. Schoolchildren in Surgut were taller in most age- and gender groups than their counterparts from St. Petersburg. Significant differences in height were observed among 8, 9 and 11 year-olds (p = 0.001 p = 0.015). In weight the differences were observed among 11 and 14 years old (p = 0.004 ÷ 0.006). Significant differences between children in Surgut and Novy Urengoy were observed for body length among 8, 9, 11, 13 and 14 year-olds (p <0.001 ÷ p = 0.01). Children in St. Petersburg were taller at the age of 14 than in their peers in Novy Urengoy (p = 0.002). The puberty intersection of somatometric indicators in boys and girls is more pronounced in schoolchildren of Novy Urengoy: girls were taller than boys at 11 (147.2 and 144.9 cm; p = 0.012) and 12 years (151.7 and 151.1 cm) and heavier at the age of 11 (41.8 and 40.0 kg; p = 0.012), 12 (45.77 and 44.4 kg; p = 0.013) and 13 (52.8 and 52.2 kg) years. Girls were taller than at the age of 12 in Surgut (155.6 and 153.1 cm; p < 0.001) and St. Petersburg (154.3 and 153.0 cm; p = 0.002). Conclusions. Our findings suggest that physical development in schoolchildren may depend on living conditions. Another finding is that sexual dimorphism decreases at puberty. Our results can be used as a guide when conducting medical examination of schoolchildren.

The aim: To analyze the incidence of malignant neoplasms in the main cities of the Siberian Federal District of Russia. Methods: Data were collected from annual forms of the Federal Statistical Monitoring N 7 "Information about Malignant Neoplasms" for the cities of Gorno-Altaisk, Ulan-Ude, Abakan, Barnaul, Chita, Krasnoyarsk, Irkutsk, Kemerovo, Novosibirsk, Omsk and Tomsk. Main epidemiological indicators were calculated by gender for the period from 2004-2018. Results. In 2018, 31 636 cases of cancer were registered in the cities which accounts for 39.9 % of the total number of the malignant neoplasms in whole District. The most common malignancies in male population were lung cancer (16.3 %), prostate cancer (12.5 %), skin melanoma (12.1 %), colorectal cancer (11.7 %) and stomach cancer (7.1 %). Among women, breast cancer (21.5 %), skin melanoma (17.3 %), colorectal cancer (11.5 %), uterine cancer (6.4 %) and cervical cancer (5.0 %) were the most common malignancies. Standardized rates of the increased overall cancer incidence from 271,0 to 287,2 %000 during the study period. The highest standardized incidence rate was observed in the cities of Ulan-Ude (267.9 %000), Chita (253.6 %000), Krasnoyarsk (308.2 %000) and Omsk (305.9 %000). According to prediction model, the cancer incidence may increase to 307.4 %000 by 2025. Conclusion. Urban population of Siberia has high incidence of malignant neoplasms. The incidence rate has been gradually increasing over the years and may further increase by 2025 if no measures are taken.